Biomolecule‐cell interactions and the regulation of myelopoiesis

Abstract

The regulation of myelopoiesis in vivo most likely entails a complex set of interactions between cell-derived biomolecules and their target cells. Much of what we currently know of these interactions has been derived from studies in vitro utilizing techniques for the purification of both the biomolecules and the cells producing and responding to these factors. Stimulating and suppressing influences have been uncovered, and with the cloning and purification of biologically active factors, studies assessing the actions of these molecules in vivo have begun. From studies in vitro it is apparent that many of the purified molecules can have move than one action and that different molecules can collaborate in a synergistic manner to enhance or suppress functional endpoints.

Lactoferrin suppress the adipogenic differentiation of MC3T3-G2/PA6 cells

“…Given its presence in exocrine glands and the secondary granules of neutrophilic leukocytes, lactoferrin is found in many body fluids, including milk, saliva, tears, bile, and pancreatic fluid (2). To date, lactoferrin has been shown to be involved in a variety of biological functions such as cell growth and differentiation (3)(4)(5), modulation of the inflammatory response (6), antiviral effects (7), and the regulation of myelopoiesis (8,9).…”

Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.

“…Myeloid blood cell production is regulated by networks of cell interactions involving production and release from accessory cells of molecules such as the hematopoietic colony-stimulating factors (CSFs): multi-CSF [also termed interleukin 3 (IL-3)], granulocyte-macrophage (GM)-CSF, granulocyte (G)-CSF, macrophage-CSF, as well as erythropoietin (Epo), and interleukins 1-6 (3)(4)(5)40). Activin and inhibin, which, respectively, enhance and suppress release of follicle-stimulating hormone from pituitary cells in vitro (6)(7)(8)(9), have been shown to influence erythroid cells in vitro (10)(11)(12).…”

Lactoferrin Inhibits Platelet Production from Human Megakaryocytes in Vitro

“…9,10) To date, it has been reported that LF is involved in a variety of biological functions, such as cell growth and differentiation, [11][12][13] modulation of the inflammatory response, 14) anti-viral effects, 15) and regulation of myelopoiesis. 16,17) LF showed inhibitory effects on PLT aggregation by binding to the LF receptor which exists on the surface of PLTs, 5) but it is unclear whether LF can act on MKs though the LF receptor on the MKs. 6) Therefore, we assume that LF may contribute to differentiation of MKs as well as being involved in cell proliferation and differentiation.…”