Biomolecularly stimuli-responsive tetra-poly(ethylene glycol) that undergoes sol–gel transition in response to a target biomolecule

Norioka, Chisa; Okita, Kazuma; Mukada, Miho; Kawamura, Akifumi; Miyata, Takashi

doi:10.1039/c7py01370a

Cited by 27 publications

(37 citation statements)

References 30 publications

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“…For instance, gels are often observed to turn back to sols under excess presence of ions (reentrant sol-gel-sol transition) [26]. Similar reentrant transitions were also observed in polymer solutions with biomolecularly recognizable cross-link junctions [27].…”

Section: Introduction: Binary Gels With Mixed Cross-linksmentioning

confidence: 74%

Thermoreversible Gelation with Two-Component Mixed Cross-Link Junctions of Variable Multiplicity in Ternary Polymer Solutions

Tanaka

2021

Gels

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Theoretical scheme is developed to study thermoreversible gelation interfering with liquid–liquid phase separation in mixtures of reactive f-functional molecules R{Af} and g-functional ones R{Bg} dissolved in a common solvent. Formed polymer networks are assumed to include multiple cross-link junctions containing arbitrary numbers k1 and k2 of functional groups A and B of each species. Sol-gel transition lines and spinodal lines are drawn on the ternary phase plane for some important models of multiple cross-link junctions with specified microscopic structure. It is shown that, if the cross-link structure satisfies a certain simple condition, there appears a special molar ratio of the two functional groups at which gelation takes place with a lowest concentration of the solute molecules, as has been often observed in the experiments. This optimal gelation concentration depends on f and g (functionality) of the solute molecules and the numbers k1 and k2 (multiplicity) of the functional groups in a cross-link junction. For cross-links which allow variable multiplicity, special attention is paid on the perfectly immiscible cross-links leading to interpenetrating polymer networks, and also on perfectly miscible cross-links leading to reentrant sol-gel-sol transition. Results are compared with recent observations on ion-binding polymer solutions, polymer solutions forming recognizable biomolecular complexes, polymer/surfactant mixtures, hydrogen-bonding polymers, and hydrophobically-modified amphiphilic water-soluble polymers.

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Section: Introduction: Binary Gels With Mixed Cross-linksmentioning

confidence: 74%

Thermoreversible Gelation with Two-Component Mixed Cross-Link Junctions of Variable Multiplicity in Ternary Polymer Solutions

Tanaka

2021

Gels

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“…Norioka et al reported gelation of biotinylated tetra-poly(ethylene glycol) with avidin. [285] Reversibility is clearly demonstrated by transition from gel-state to sol-state after an addition of free biotin into the system. Furthermore, owing to its site-specificity, the avidinbiotin interaction can be utilized for crosslinking of functional proteins without interfering bioactivity.…”

Section: Non-covalent Bonding Stabilizationmentioning

confidence: 99%

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Habibi

Mauser

et al. 2022

Advanced Science

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Protein nanoparticles, PNPs, have played a long‐standing role in food and industrial applications. More recently, their potential in nanomedicine has been more widely pursued. This review summarizes recent trends related to the preparation, application, and chemical construction of nanoparticles that use proteins as major building blocks. A particular focus has been given to emerging trends related to applications in nanomedicine, an area of research where PNPs are poised for major breakthroughs as drug delivery carriers, particle‐based therapeutics or for non‐viral gene therapy.

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“…For example, molecularly stimuli‐responsive gels that undergo structural changes in response to target molecules have been prepared using molecular complexes, which act as dynamic crosslinks in the network. [ 24–29 ] These previous studies have demonstrated that the association and dissociation of dynamic crosslinks induce responsive changes in the volume due to the changes in the crosslinking density. Thus, we can design various stimuli‐responsive polymers using dynamic crosslinks that associate and dissociate in response to external stimuli.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive Polymer Films with Directly Micropatternable Surfaces Based on the Change in Free Volume by Photo‐Crosslinking

Noguchi

Akioka

Kojima

et al. 2022

Adv Materials Inter

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micropatterns are generated by selectively exposing photoreactive or photoresponsive polymer films to ultraviolet (UV) light in a photo-crosslinking or photodecomposition process and subsequently dissolving the selected areas of the film surfaces using an appropriate solvent. Photo lithography is widely employed as a high-resolution technique because it is suitable for large-area surface patterning with good alignment. However, it is not cost-effective because of the requirement of some complicated processes. In nanoimprint lithography based on pattern transfer processes, the patterning of polymers is fabricated by trapping a solid-state pattern by either cooling the molded material or UV-photocuring the polymer precursor after a mold is pressed against a softened thermoplastic polymer or a liquid polymer precursor. The softened thermoplastic polymer and liquid polymer precursor are driven into recessed portions of the mold by applying pressure, adhesion, or capillarity. Polymers to be patterned can be spin-cast, dispensed as droplets, or allowed to fill the space between the mold and substrate by capillary forces. [3,8,9] Recently, azopolymers with phototunable physical and chemical properties were also used in nanoimprint lithography for directional photo-manipulation of nanopatterns and micro-photo-actuators. [10,11] Nanoimprint lithography is the simplest way for producing large-area nanostructures in a low-cost and high-resolution patterning technique. However, it commonly requires high pressure, which increases the possibility of damage to the mold and substrate. Further, in nanoimprint lithography, mold fabrication using the conventional lithographic process and reactive ion etching facilities is indispensable. Simplified micropatterning techniques are necessary for surface patterning with polymers to achieve costeffective nano-and micropatterning with multiple shapes and scales. In particular, simple and cost-effective microfabrication technologies are required in developing low-cost devices and disposable chips for diagnosing diseases even though their resolution is not very high.Stimuli-responsive polymers undergo abrupt changes in their structures and properties in response to external stimuli, [12][13][14][15] such as pH, [16] temperature, [17][18][19][20] electric field, [21,22] and light. [23] According to previous studies, the stimuli-responsive behavior of the polymers is based on drastic changes in their affinity for solvents or in the osmotic pressure induced by Photoresponsive polymers, whose structures or properties change when exposed to ultraviolet (UV) light, have been studied for the fabrication of micro-and nano-devices for various applications. Herein, photoresponsive polymer films are investigated with directly micropatternable surfaces formed by only UV exposure without the development process using solvents. The photoresponsive polymer films are designed based on the decrease in free volume induced by the photodimerization of cinnamoyl groups. The photoresponsive polymers are synthesi...

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Biomolecularly stimuli-responsive tetra-poly(ethylene glycol) that undergoes sol–gel transition in response to a target biomolecule

Abstract: We designed biotin-conjugated four-armed poly(ethylene glycol) (biotinylated Tetra-PEG) as biomolecularly stimuli-responsive polymers that underwent the phase transition from a sol to a gel state in response to avidin as a target biomolecule.

Cited by 27 publications

References 30 publications

Thermoreversible Gelation with Two-Component Mixed Cross-Link Junctions of Variable Multiplicity in Ternary Polymer Solutions

Thermoreversible Gelation with Two-Component Mixed Cross-Link Junctions of Variable Multiplicity in Ternary Polymer Solutions

Protein Nanoparticles: Uniting the Power of Proteins with Engineering Design Approaches

Photoresponsive Polymer Films with Directly Micropatternable Surfaces Based on the Change in Free Volume by Photo‐Crosslinking

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