Biomolecular influenza virus detection based on the electrochemical impedance spectroscopy using the nanocrystalline boron-doped diamond electrodes with covalently bound antibodies

Siuzdak, Katarzyna; Niedziałkowski, Paweł; Sobaszek, Michał; Łęga, Tomasz; Sawczak, M.; Czaczyk, Elżbieta; Dziąbowska, Karolina; Ossowski, Tadeusz; Nidzworski, Dawid; Bogdanowicz, Robert

doi:10.1016/j.snb.2018.10.005

Cited by 62 publications

(37 citation statements)

References 68 publications

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“…Electrochemical impedance spectroscopy (EIS) is one of the most important and versatile techniques of electrochemistry. [1] EIS has been used widely in the fields of energy storage, [2,3] solid-state ionics, [4,5] fuel cells, [6,7] electrolyzers, [8] solar cells, [9,10] porous media, [11] sensors, [12] biology, [13] virological diagnostics, [14] and medicine. [15,16] The EIS technique is particularly appreciated because it can be carried out for frequencies spanning several orders of magnitude, typically from 1 mHz to 10 MHz.…”

Section: Introductionmentioning

confidence: 99%

A Bayesian view on the Hilbert transform and the Kramers-Kronig transform of electrochemical impedance data: Probabilistic estimates and quality scores

Liu

Wan

Ciucci

2020

Electrochimica Acta

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Electrochemical impedance spectroscopy (EIS) is one of the most widely used experimental tools in electrochemistry and has applications ranging from energy storage and power generation to medicine. Considering the broad applicability of the EIS technique, it is critical to validate the EIS data against the Hilbert transform (HT) or, equivalently, the Kramers-Kronig relations. These mathematical relations allow one to assess the self-consistency of obtained spectra. However, the use of validation tests is still uncommon. In the present article, we aim at bridging this gap by reformulating the HT under a Bayesian framework. In particular, we developed the Bayesian Hilbert transform (BHT) method that interprets the HT probabilistic. Leveraging the BHT, we proposed several scores that provide quick metrics for the evaluation of the EIS data quality.

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Section: Introductionmentioning

confidence: 99%

A Bayesian view on the Hilbert transform and the Kramers-Kronig transform of electrochemical impedance data: Probabilistic estimates and quality scores

Liu

Wan

Ciucci

2020

Electrochimica Acta

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“…After growth, NCD films can be processed to form two or three-dimensional suspended structures [11,12] and the surface of an NCD film can be functionalized with a variety of (bio)molecules for use in biosensors [13] and solar cells [14]. Due to these excellent properties, NCD based devices such as micromechanical resonators of high Q-factor [15,16], pressure sensors for harsh environments [17,18], tunable optical lenses [19], biosensors that, for example, can detect influenza [20,21], optically transparent electrodes [22,23], CO 2 reducing electrodes [24], superconducting quantum interference devices [25], and conducting atomic force microscope tips are being developed [26].…”

Section: Introductionmentioning

confidence: 99%

Nanocrystalline diamond-glass platform for the development of three-dimensional micro- and nanodevices

Janssens

Vázquez-Cortés

Giussani

et al. 2019

Diamond and Related Materials

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Low-cost and robust platforms are key for the development of next-generation 3D micro-and nanodevices. To fabricate such platforms, nanocrystalline diamond (NCD) is a highly appealing material due to its biocompatibility, robustness, and mechanical, electrical, electrochemical, and optical properties, while glass substrates with through vias are ideal interposers for 3D integration due to the excellent properties of glass. However, developing devices that are comprised of NCD films and through glass vias (TGVs) has rarely been attempted due to a lack of effective process strategies. In this work, a low-cost process -free of photolithography and transfer-printing -for fabricating arrays of TGVs that are sealed with suspended portions of an ultra-thin NCD film on one side is presented. These highly transparent structures may serve as a platform for the development of microwells for single-cell culture and analysis, 3D integrated devices such as microelectrodes, and quantum technologies. The process is demonstrated by fabricating TGVs that are sealed with an NCD film of thickness 175 nm and diameter 60 µm. The technology described can be extended by replacing NCD with silicon nitride or silicon carbide, allowing for the development of complex heterogenous structures on the small scale.

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“…The nanocrystalline boron-doped diamond-based electrode (B:NCD) was used as platform of biosensor. The modified material is a highly promising material for the thirdgeneration biosensor due to its chemical inertness, wide potential window, low background current, biocompatibility, and high stability [117].…”

Section: Methodsmentioning

confidence: 99%

Electrochemical virus detections with nanobiosensors

Kaya

Karadurmuş

Özçelikay

et al. 2020

Nanosensors for Smart Cities

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Biomolecular influenza virus detection based on the electrochemical impedance spectroscopy using the nanocrystalline boron-doped diamond electrodes with covalently bound antibodies

Cited by 62 publications

References 68 publications

A Bayesian view on the Hilbert transform and the Kramers-Kronig transform of electrochemical impedance data: Probabilistic estimates and quality scores

A Bayesian view on the Hilbert transform and the Kramers-Kronig transform of electrochemical impedance data: Probabilistic estimates and quality scores

Nanocrystalline diamond-glass platform for the development of three-dimensional micro- and nanodevices

Electrochemical virus detections with nanobiosensors

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