Biomolecular endotype factors involved in COVID-19 airway infectivity: A systematic review

Jain, Neil; Varman, Rahul; Tarbox, James; Nguyên, Tam

doi:10.1016/j.anl.2020.11.006

Cited by 3 publications

(6 citation statements)

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Section: Vitamin D and Covid-19mentioning

confidence: 99%

“…5,85 Nonetheless, further research is needed to understand the effects of Vitamin D and the role of various cytokines prevalent in nasal/pharyngeal illnesses on COVID-19 pathogenesis, which may actually lead to novel therapeutic indications. 90 reduction of pro-inflammatory cytokines and increasing antiinflammatory cytokines, enhancement of natural antimicrobial peptides, and activation of defensive cells such as macrophages that could destroy SARS-CoV-2. 91 More importantly and directly relevant to the subject, vitamin D might alleviate ARDS and acute lung injury induced by SARS-CoV-2 by modulating ACE2.…”

Section: Vitamin D and Covid-19mentioning

confidence: 99%

“…Suppression of cytokine response and reduced severity/risk for ARDS were evident by a meta‐analysis where regular oral vitamin D 2 /D 3 intake (in doses up to 2000 IU/day) was found to be safe and protective against acute respiratory tract infection and COVID‐19 5,85 . Nonetheless, further research is needed to understand the effects of Vitamin D and the role of various cytokines prevalent in nasal/pharyngeal illnesses on COVID‐19 pathogenesis, which may actually lead to novel therapeutic indications 90 …”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Getachew

Tizabi

2021

Journal of Medical Virology

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Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus, disproportionally targets older people, particularly men, ethnic minorities, and individuals with underlying diseases such as compromised immune system, cardiovascular disease, and diabetes. The discrepancy in COVID‐19 incidence and severity is multifaceted and likely involves biological, social, as well as nutritional status. Vitamin D deficiency, notably common in Black and Brown people and elderly, is associated with an increased susceptibility to many of the diseases comorbid with COVID‐19. Vitamin D deficiency can cause over‐activation of the pulmonary renin‐angiotensin system (RAS) leading to the respiratory syndrome. RAS is regulated in part at least by angiotensin‐converting enzyme 2 (ACE2), which also acts as a primary receptor for SARS‐CoV‐2 entry into the cells. Hence, vitamin D deficiency can exacerbate COVID‐19, via its effects on ACE2. In this review we focus on influence of age, gender, and ethnicity on vitamin D‐ACE2 interaction and susceptibility to COVID‐19.

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Section: Vitamin D and Covid-19mentioning

confidence: 99%

Section: Vitamin D and Covid-19mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Getachew

Tizabi

2021

Journal of Medical Virology

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“…33 Lack of adherence to physician instructions can have a notable effect on the cost of health care in the range of $5271 to $52,341 per person each year. 34 Mitigating these extra costs is crucial for improving the sustainability of medical practices including orthopaedic surgery.…”

Section: Strategies For Improvementmentioning

confidence: 99%

Factors Influencing Compliance to Follow-up Visits in Orthopaedic Surgery

Bender,

Jain,

Giron

et al. 2024

JAAOS Glob Res Rev

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Background: Orthopaedic procedures require postoperative follow-up to maximize recovery. Missed appointments and noncompliance can result in complications and increased healthcare costs. This study investigates the relationship between patient postoperative visit attendance and the distance traveled to receive care. Materials and Methods: A retrospective review of all surgeries performed by a single orthopaedic surgeon in 2019 at level 1 trauma center in a midsized city serving a largely rural population was completed. We excluded patients who underwent another subsequent procedure. Distance to care and time traveled were determined by the patient's address and the clinic address using Google Maps Application Programming Interface. Other variables that may affect attendance at follow-up visits were also collected. Univariate and multivariate logistic regression was done with purposeful selection. Results: We identified 518 patients of whom 32 (6%) did not attend their first scheduled follow-up appointment. An additional 47 (10%) did not attend their second follow-up. In total, 79 patients (15%) did not attend one of their appointments. Younger age, male sex, Black or African American race, self-pay, Medicaid insurance, accident insurance, and increased distance were individual predictors of missing an appointment. In the final multivariate logistic regression model, male sex (OR 1.74), Black or African American race (OR 2.78), self-pay (OR 3.12), Medicaid (OR 3.05), and traveling more than 70 miles to clinic (OR 2.02) markedly predicted missing an appointment, while workers' compensation (OR 0.23) predicted attendance. Discussion: Several nonmodifiable patient factors predict patient noncompliance in attending orthopaedic postoperative visits. When patients are considered at high risk of being lost to follow-up, there may be an opportunity to implement interventions to improve follow-up rate and patient outcomes, minimize patient costs, and maximize profitability for the hospital.

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“…Some of the mechanisms behind the beneficial effects of vitamin D involve inhibition of pro-inflammatory cytokines in human monocytes/macrophages [ 19 ], as well as inhibition of the Renin Angiotensin System (RAS) [ 20 ]. The angiotensin-converting enzyme 2 (ACE2) receptor, the point of entry of SARS-CoV-2 and protective against hypertension and inflammation [ 21 , 22 ], is strengthened by vitamin D via heightened expression that balances ACE/ACE2 and angiotensin II (ANG)/ANG 1–7, pathways that are known to be disrupted by coronaviruses [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study

et al. 2021

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Objectives Vitamin D status in patients with COVID-19 is an on-going controversial issue. This study aims to determine differences in the serum 25(OH)D concentrations of Arab Gulf adult residents screened for SARS-CoV-2 and its association with risk of COVID-19 infection together with other comorbidities. Methods In this multi-center, case–control study, a total of 220 male and female adults presenting with none to mild symptoms were screened for COVID-19 (n = 138 RT-PCR-confirmed SARS-CoV-2 positive and 82 negative controls). Medical history was noted. Anthropometrics were measured and non-fasting blood samples were collected for the assessment of glucose, lipids, inflammatory markers and serum 25(OH)D concentrations. Results Serum 25(OH)D levels were significantly lower in the SARS-CoV-2 positive group compared to the negative group after adjustment for age and BMI (52.8 nmol/l ± 11.0 versus 64.5 nmol/l ± 11.1; p = 0.009). Being elderly (> 60 years) [Odds ratio 6 (95% Confidence Interval, CI 2–18; p = 0.001) as well as having type 2 diabetes (T2D) [OR 6 (95% CI 3–14); p < 0.001)] and low HDL cholesterol (HDL-c) [OR 6 (95% CI 3–14); p < 0.001)] were significant risk factors for COVID-19 infection independent of age, sex and obesity. Conclusions Among Arab Gulf residents screened for SARS-CoV-2, serum 25(OH) D levels were observed to be lower in those who tested positive than negative individuals, but it was the presence of old age, diabetes mellitus and low-HDL-c that were significantly associated with risk of COVID-19 infection. Large population-based randomized controlled trials should be conducted to assess the protective effects of vitamin D supplementation against COVID-19.

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Biomolecular endotype factors involved in COVID-19 airway infectivity: A systematic review

Abstract: To review the current knowledge of biomolecular factors surrounding otorhinolaryngeal illnesses and analyze their presence in COVID-19 virulence. Emphasis was placed on cytokines and vitamin D for determining susceptibility of illness.

Cited by 3 publications

References 40 publications

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Factors Influencing Compliance to Follow-up Visits in Orthopaedic Surgery

Vitamin D status of Arab Gulf residents screened for SARS-CoV-2 and its association with COVID-19 infection: a multi-centre case–control study

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