Biomolecular and Clinical Aspects of Chinese Wolfberry

Wachtel-Galor, S; Yuen, John; Buswell, John A.; Benzie, Iris F.F.

doi:10.1201/b10787-15

Cited by 37 publications

(28 citation statements)

References 82 publications

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“…This can be explained if polysaccharides containing higher Ara have a larger molecular weight but smaller Rz than those containing higher GalA [37]. The molecular weight of AL L and A L are much higher than the previously published LBP-4a (34kDa), LbGp3 (50-60kDa) and LBP1 (925kDa) [35,38,39], which may be due to the better preservation of side chains during the low temperature extraction in the present study.…”

Section: Homogeneity Molecular Weight and Conformation Of Lbpscontrasting

confidence: 57%

“…In view of the fact that arabinogalactan-protein (AGP) is an important glycoconjugate presented in LBPs, a large part of the neutral sugar branches of RG-I should be tightly bound to protein in goji pectic polysaccharides [34]. The molecular weight of AGP in goji varies from 24 to 920 kDa [35], so it was hypothesized that, even if the side chains are degraded during extraction, the glycoconjugate will be co-precipitated together with polysaccharides and will not be all lost on dialysis because of their large molecular weight. According to this conjecture, a schematic diagram of the goji cell wall is shown in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Extraction Methods Affect the Structure of Goji (Lycium barbarum) Polysaccharides

Zhou

Rahman

et al. 2020

Molecules

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Polysaccharides are considered to be the most important active substances in Goji. However, the structure of polysaccharides varies according to the extraction methods applied, and the solution used to prepare Goji polysaccharides (LBPs) were limited. Thus, it is important to clarify the connection between extraction methods and structure of Goji polysaccharide. In view of the complex composition of cell wall polysaccharides and the various forms of interaction, different extraction methods will release different parts of the cell wall. The present study compared the effects of different extraction methods, which have been used to prepare different types of plant cell wall polysaccharides based on various sources, on the structure of cell-wall polysaccharides from Goji, by the single separate use of hot water, hydrochloric acid (0.4%) and sodium hydroxide (0.6%), at both high and low temperatures. Meanwhile, in order to explore the limitations of single extraction, sequential extraction methods were applied. Structural analysis including monosaccharide analysis, GPC-MALLS, AFM and 1H-NMR suggested the persistence of more extensively branched rhamnogalacturonan I (RG-I) domains in the procedures involving low-temperature-alkali, while procedures prepared by high-temperature-acid contains more homogalacturonan (HG) regions and results in the removal of a substantial part of the side chain, specifically the arabinan. A kind of acidic heteropolysaccharide was obtained by hot water extraction. SEC-MALLS and AFM confirmed large-size polymers with branched morphologies in alkali-extracted polysaccharides. Our results provide new insight into the extraction of Goji polysaccharides, which differ from the hot water extraction used by traditional Chinese medicine.

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Section: Homogeneity Molecular Weight and Conformation Of Lbpscontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Extraction Methods Affect the Structure of Goji (Lycium barbarum) Polysaccharides

Zhou

Rahman

et al. 2020

Molecules

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“…For centuries, goji berry (Lycium barbarum L.) has been used in traditional medicine in China [1] and, in recent years, the large customer demand for goji berry-related food products resulted in producing these berries even in western countries, among which Italy. Recently, the production and sale of raw berries and goji berry-related food products (juices, jams, bakery products, energy bars) have increased rapidly since these berries have been described as superfood [2].…”

mentioning

confidence: 99%

Italian Lycium barbarum L. Berry: Chemical Characterization and Nutraceutical Value

Montesano

Rocchetti

Cossignani

et al. 2018

Natural Product Communications

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Lycium barbarum L. has received considerable attention in recent years also in western countries because of the interesting healthy value of these berries. In this paper, goji samples cultivated in Southern Italy were analyzed for their chemical composition and nutritional profile in order to characterize fruits of Italian origin and to increase the awareness about their nutraceutical value. Lipid fraction was characterized by high percentages of unsaturated fatty acids, in particular oleic and linoleic acids, and very low values of atherogenic and thrombogenic indexes (0.1 and 0.2, respectively). In addition, goji berry was an interesting source of phytosterols (41.5 mg/100 g), essentially represented by β-sitosterol. Carotenoid analysis showed the presence of zeaxanthin, in esterified form, with high content of zeaxanthin dipalmitate (277.9 mg/100 g). Finally, in vitro antioxidant capacity and phenolic compounds were investigated. The results suggested that goji hydro-alcoholic extract possessed the ability to scavenge free radicals. Phenolic acids were clearly the most abundant compounds followed by flavonols and favanols. The results reported in this study confirm that Italian L. barbarum berry is a rich source of bioactive molecules with nutraceutical properties.

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“…Furthermore, improvement of β-cells activity in the present work might be due to direct cytoprotective and indirect hypoglycemic effects of the extract. In concomitant to this hypothesis it was reported that goji caused significant decrease in the fasting blood glucose and malondialdehyde levels in streptozotocin-induced rat diabetes [40] . The mechanism of its hypoglycemic effect remains controversy.…”

Section: Discussionmentioning

confidence: 88%

Can Goji Berry Extract Attenuate Pancreatic Structural Changes Induced by Patulin Toxin in Male Albino Rats?

Soliman

2017

Egyptian Journal of Histology

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Introduction: Patulin is considered the most common mycotoxins in moldy fruits especially apples and its products like juice and compote. Goji berry (lycium barbarum fruit) is a traditional Chinese herb. It has several biological activities as antioxidant, anti-aging and hypoglycemic properties. Aim: To demonstrate the toxic effect of patulin on the pancreatic tissue and to evaluate the possible role of goji extract. Material and Methods: Forty adult male albino rats were divided equally into four groups. Group I served as the control group. Group II received subcutaneous injection of 2 ml/kg/day goji extract for four weeks. Group III received subcutaneous injection of patulin 0.2 mg/kg/day for four weeks. Group IV received patulin and goji extract with the same previous doses for four weeks. Histological and immunohistochemical studies were done. Results: The administration of patulin led to degenerative changes in the pancreas. There was a significant increase in caspase-3 positive cells in both acini and islets of Langerhans. Ultrastructural examination revealed heterochromatic nuclei, cytoplasmic vacuoles and few secretory granules in acinar cells. The β cells of the islets exhibited a significant decrease in the area percentage and intensity of insulin positive cells. Goji extract could effectively improve these histological changes. Conclusion: Patulin toxicity affected both exocrine acini and β cells of islets of Langerhans. The goji extract had a protective role on this toxicity.

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Biomolecular and Clinical Aspects of Chinese Wolfberry

Cited by 37 publications

References 82 publications

Extraction Methods Affect the Structure of Goji (Lycium barbarum) Polysaccharides

Extraction Methods Affect the Structure of Goji (Lycium barbarum) Polysaccharides

Italian Lycium barbarum L. Berry: Chemical Characterization and Nutraceutical Value

Can Goji Berry Extract Attenuate Pancreatic Structural Changes Induced by Patulin Toxin in Male Albino Rats?

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