Biomodulation of an implant for enhanced bone-implant anchorage

Raina, Deepak; Larsson, David; Sezgin, Erdem Aras; Isaksson, Hanna; Tägil, Magnus; Lidgren, Lars

doi:10.1016/j.actbio.2019.07.009

Cited by 35 publications

(55 citation statements)

References 41 publications

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“…A PEEK implant was used over conventional titanium to avoid metal artefacts seen using X-ray-based imaging of metallic implants. A detailed description of the chamber model is mentioned elsewhere (Raina et al 2019). In brief, a 3.2 mm Ø hole was created in the right proximal tibia of rats just under the tibial epiphysis.…”

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

“…2 groups were used for evaluation of bone-implant anchorage; (1) Empty PEEK implant (control) and (2) PEEK implant filled with a CaS/HA biomaterial. The control group involving the use of the empty implant has also been described earlier in our recent study and data are used for comparison only (Raina et al 2019). 22 male SD rats were divided into 2 equally sized groups (average weight = 378 g, n = 11/group).…”

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

“…Radiography and Micro-CT imaging was performed using a NanoScan micro CT scanner (Mediso Medical Imagining System, Budapest, Hungary) to obtain images with an effective voxel size of 10 µm (X-ray voltage: 65 kV, current: 123 µA, exposure: 1300 ms). Peri-implant bone formation was measured immediately around the implant holes within the medullary canal and expressed as bone volume (BV) based on established protocols (Raina et al 2019).…”

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

“…All specimens were subjected to a pre-loading protocol for 10 s before a total pull-out was performed. A load rate of 0.5 mm/s was used for the pull-out and the force-displacement curves were used to obtain the peak force (Raina et al 2019).…”

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

“…a indicates p < 0.001 and b indicates p < 0.01 (Mann-Whitney U-test). Data for the empty group are taken from an earlier study for comparison (Raina et al 2019).…”

Section: Effect Of Hydroxyapatite Particle Size On 14 C-za Uptakementioning

confidence: 99%

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Synthetic hydroxyapatite: a recruiting platform for biologically active molecules

et al. 2019

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Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

Section: Implant Integration Model: Biological Effect Of Biomodulatinmentioning

confidence: 99%

“…a indicates p < 0.001 and b indicates p < 0.01 (Mann-Whitney U-test). Data for the empty group are taken from an earlier study for comparison (Raina et al 2019).…”

Section: Effect Of Hydroxyapatite Particle Size On 14 C-za Uptakementioning

confidence: 99%

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Synthetic hydroxyapatite: a recruiting platform for biologically active molecules

et al. 2019

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Biomimetic Mineralized Fiber Bundle‐Inspired Scaffolding Surface on Polyetheretherketone Implants Promotes Osseointegration

Xin

Shi

Ning

et al. 2023

Macromolecular Bioscience

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The stress shielding effect caused by traditional metal implants is circumvented by using polyetheretherketone (PEEK), due to its excellent mechanical properties; however, the biologically inert nature of PEEK limits its application. Endowing PEEK with biological activity to promote osseointegration would increase its applicability for bone replacement implants. A biomimetic study is performed, inspired by mineralized collagen fiber bundles that contact bone marrow mesenchymal stem cells (BMMSCs) on the native trabecular bone surface. The PEEK surface (P) is first sulfonated with sulfuric acid to form a porous network structure (sP). The surface is then encapsulated with amorphous hydroxyapatite (HA) by magnetron sputtering to form a biomimetic scaffold that resembles mineralized collagen fiber bundles (sPHA). Amorphous HA simulates the composition of osteogenic regions in vivo and exhibits strong biological activity. In vitro results show that more favorable cell adhesion and osteogenic differentiation can be attained with the novelsurface of sPHA than with SP. The results of in vivo experiments show that sPHA exhibits osteoinductive and osteoconductive activity and facilitates bone formation and osseointegration. Therefore, the surface modification strategy can significantly improve the biological activity of PEEK, facilitate effective osseointegration, and inspire further bionic modification of other inert polymers similar to PEEK.

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Sustained and controlled delivery of doxorubicin from an in-situ setting biphasic hydroxyapatite carrier for local treatment of a highly proliferative human osteosarcoma

et al. 2021

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Biomodulation of an implant for enhanced bone-implant anchorage

Cited by 35 publications

References 41 publications

Synthetic hydroxyapatite: a recruiting platform for biologically active molecules

Synthetic hydroxyapatite: a recruiting platform for biologically active molecules

Biomimetic Mineralized Fiber Bundle‐Inspired Scaffolding Surface on Polyetheretherketone Implants Promotes Osseointegration

Sustained and controlled delivery of doxorubicin from an in-situ setting biphasic hydroxyapatite carrier for local treatment of a highly proliferative human osteosarcoma

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