Biomodulation: An integrated approach to access and manipulate biological information

Mann, Paul L.; Eshima, Dennis; Bitner, D. M.; Griffey, Richard H.; Wenk, Robert E.; Born, Jerry L.; Matwiyoff, Nicholas A.

doi:10.1007/978-3-642-76739-5_13

Cited by 6 publications

(10 citation statements)

References 16 publications

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“…This hypothesis is supported by the NMR modulation of proton exchange rates and the very short time span for the biomodulation of this effect (Busse et al, 1989). This purported structural change in cell surface oligosaccharide arrangement is also found as a component of "normal" regulatory cellular process(es) (Mann et al, 1991(Mann et al, , 1992. There is also an induced change at the physiology 526 I Biomodulation, the Development of a Process-Oriented Approach to Cancer Treatment tissue response.…”

Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 59%

“…From the perspective of our problem this data indicates that the Biomodulator has specificity for the tumor (Mann et al, 1991). Once it traffics level between the normal and aberrant tissue.…”

Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 94%

“…Biomodulation [a subset of BRMs] is the natural, inherent mechanism(s) by which the complex biological system manages information including recognition, coordination of effort, and integration of purpose. We have described several classes of Biomodulator [dissection of the whole for understanding only] which range from natural products [plant and microbial products] to their synthetic analogs (Mann et al, 1991). This multi-faceted approach is considered important as it connects the definition of detailed mechanism(s), i.e.…”

Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 99%

See 2 more Smart Citations

Biomodulation, the Development of a Process–Oriented Approach to Cancer Treatment

Mann¹,

Wenk²,

Raymond-Stintz³

1996

Glycosciences

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Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 59%

Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 94%

Section: Recent Uses Of Brm/ Biomodulator Terminologymentioning

confidence: 99%

See 1 more Smart Citation

Biomodulation, the Development of a Process–Oriented Approach to Cancer Treatment

Mann¹,

Wenk²,

Raymond-Stintz³

1996

Glycosciences

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“…P-galactosides and their sialylated derivatives, may thus be transformed from in vitro ligands with quite similar behavior to a spectrum with significantly different ligand properties. Incidentally, modulation of affinity class distribution of plant lectin ligands has been shown to occur in vitro in the course of cell differentiation and malignant transformation (Mann et al, 1991). In sum, although work on animal lectins has thus blossomed into a dynamic field with indisputable potential for applications, one should not be deluded into prematurely expecting final answers throughout the field at this stage.…”

Section: Discussionmentioning

confidence: 99%

Animal Lectins

Gabius

1997

European Journal of Biochemistry

435

342

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Protein and lipid glycosylation is no longer considered as a topic whose appeal is restricted to a limited number of analytical experts perseveringly pursuing the comprehensive cataloguing of structural variants. It is in fact arousing curiosity in various areas of basic and applied bioscience. Well founded by the conspicuous coding potential of the sugar part of cellular glycoconjugates which surpasses the storage capacity of oligonucleotide-or oligopeptide-based code systems, recognition of distinct oligosaccharide ligands by endogenous receptors, i.e. lectins and sugar-binding enzymes or antibodies, is increasingly being discovered to play salient roles in animal physiology. Having inevitably started with a descriptive stage, research on animal lectins has now undubitably reached maturity. Besides listing the current categories for lectin classification and providing presentations of the individual families and their presently delineated physiological significance, this review places special emphasis on tracing common structural and functional themes which appear to reverberate in nominally separated lectin and animal categories as well as lines of research which may come to fruition for medical sciences.Keywords: lectin ; glycoprotein; glycolipid; cell adhesion ; molecular recognition ; inflammation; infection ; fertilization ; signal transduction ; tumor biology.The putative multiplicity of functional implications for protein and lipid glycosylation has fueled vigorous and prolific research activities in the last decade. Although glycobiologists continue to be afflicted with the problem of precisely defining the physiological significance of the puzzling variability and complex pattern of carrier-attached saccharide chains, the notion of inherent ligand properties for recognitive protein-carbohydrate interactions is already well established

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“…A key article by Mann et al 18 appeared in the publication Lectins and Cancer that covered the proceedings of a symposium on cancer applications of lectins. The initial part of this manuscript reviewed in detailed chemical terminology the characteristics of various modifiers, those of significant importance including PWM and related compounds which share a chemical configuration thought to be basic to their common immunomodulating effect.…”

Section: Application Of Pwm For Hiv-1 Infectionsmentioning

confidence: 99%

Mitogens for Curative Therapy of HIV-1 Infections; an Update

Wimer¹

2002

Cancer Biotherapy and Radiopharmaceuticals

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The curative objectives of administering mitogens in conjunction with HAART have been to initiate killer reactions against HIV-1, replenish CD4 cells, rejuvenate CD8 cells, stimulate effective immune reactions against malignancies, generate tolerated immune responses against conventional and opportunistic infections, resist treatment-evading tactics of HIV mutations, and reconstitute both immune and hematopoietic competences. With recent observations that these aims might be thwarted by sequestration of HIV-1 infection in memory cells residing in the circulation, lymph nodes, and spleen as well as in various other sites not readily accessible to eradication, stronger emphasis should be focused primarily on mitogen-induced blockage of HIV-1 entry into CD4 cells. Equally important would be the mitogen panactivation of any cells sequestering virions and proviruses, thereby forcing them out of the latent G0 phase and exposing them to destruction by HAART and the immune responses. While the currently best established mitogens for HIV-1 therapy, PHA-L4 and PWM, might be successfully applied independently or in tandem, other mitogens may be found suitable for evaluation.

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Biomodulation: An integrated approach to access and manipulate biological information

Cited by 6 publications

References 16 publications

Biomodulation, the Development of a Process–Oriented Approach to Cancer Treatment

Biomodulation, the Development of a Process–Oriented Approach to Cancer Treatment

Animal Lectins

Mitogens for Curative Therapy of HIV-1 Infections; an Update

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