BioMIPs: molecularly imprinted silk fibroin nanoparticles to recognize the iron regulating hormone hepcidin

Bossi, Alessandra Maria; Maniglio, Devid

doi:10.1007/s00604-022-05165-0

Cited by 10 publications

(6 citation statements)

References 41 publications

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“…It is possible therefore that biologically sources polymers could be used to improve MIP performance while simultaneously addressing environmental concerns. Recent examples of silk-based MIP nanoparticles for aqueous applications provide a foundation for this technology [ 207 , 208 ].…”

Section: Template Imprintingmentioning

confidence: 99%

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Cowen

Cheffena

2022

IJMS

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The selective sensing of gaseous target molecules is a challenge to analytical chemistry. Selectivity may be achieved in liquids by several different methods, but many of these are not suitable for gas-phase analysis. In this review, we will focus on molecular imprinting and its application in selective binding of volatile organic compounds and atmospheric pollutants in the gas phase. The vast majority of indexed publications describing molecularly imprinted polymers for gas sensors and vapour monitors have been analysed and categorised. Specific attention was then given to sensitivity, selectivity, and the challenges of imprinting these small volatile compounds. A distinction was made between porogen (solvent) imprinting and template imprinting for the discussion of different synthetic techniques, and the suitability of each to different applications. We conclude that porogen imprinting, synthesis in an excess of template, has great potential in gas capture technology and possibly in tandem with more typical template imprinting, but that the latter generally remains preferable for selective and sensitive detection of gaseous molecules. More generally, it is concluded that gas-phase applications of MIPs are an established science, capable of great selectivity and parts-per-trillion sensitivity. Improvements in the fields are likely to emerge by deviating from standards developed for MIP in liquids, but original methodologies generating exceptional results are already present in the literature.

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Section: Template Imprintingmentioning

confidence: 99%

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Cowen

Cheffena

2022

IJMS

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“…Only recently have there been a few reports on biopolymer-based MIPs. Some of the explored biodegradable polymers are silk [ 202 ] and chitosan [ 203 ]. More research is needed to develop more of these bio-MIPs.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Biomimetic Systems for Sensing Environmental Contaminants, Biomarkers, and Bioimaging Applications

Ramajayam,

Ganesan,

Ramesh

et al. 2023

Biomimetics

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Molecularly imprinted polymers (MIPs), a biomimetic artificial receptor system inspired by the human body’s antibody-antigen reactions, have gained significant attraction in the area of sensor development applications, especially in the areas of medical, pharmaceutical, food quality control, and the environment. MIPs are found to enhance the sensitivity and specificity of typical optical and electrochemical sensors severalfold with their precise binding to the analytes of choice. In this review, different polymerization chemistries, strategies used in the synthesis of MIPs, and various factors influencing the imprinting parameters to achieve high-performing MIPs are explained in depth. This review also highlights the recent developments in the field, such as MIP-based nanocomposites through nanoscale imprinting, MIP-based thin layers through surface imprinting, and other latest advancements in the sensor field. Furthermore, the role of MIPs in enhancing the sensitivity and specificity of sensors, especially optical and electrochemical sensors, is elaborated. In the later part of the review, applications of MIP-based optical and electrochemical sensors for the detection of biomarkers, enzymes, bacteria, viruses, and various emerging micropollutants like pharmaceutical drugs, pesticides, and heavy metal ions are discussed in detail. Finally, MIP’s role in bioimaging applications is elucidated with a critical assessment of the future research directions for MIP-based biomimetic systems.

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“…The use of silk fibroin for the preparation of MIP nanoparticles for the selective recognition of human serum albumin and hepcidin was recently proposed [86,87]. Such MIP nanoparticles were in addition successfully coupled to silk microfibers and to silk electrospun nanofibers leading to all-silk MIP-nanoparticles fiber superstructures.…”

Section: F I G U R E 1mentioning

confidence: 99%

Recent advances and future trends in molecularly imprinted polymers‐based sample preparation

Díaz‐Álvarez¹,

Turiel²,

Martín‐Esteban³

2023

J of Separation Science

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Molecular imprinting technology is a well‐established technique for the obtainment of tailor‐made polymers, so‐called molecularly imprinted polymers, with a predetermined selectivity towards a target analyte or structurally related compounds. Accordingly, molecularly imprinted polymers are considered excellent materials for sample preparation providing unprecedented selectivity to analytical methods. However, the use of molecularly imprinted polymers in sample preparation still presents some shortcomings derived from the synthesis procedure itself limiting its general applicability. In this regard, molecularly imprinted polymers use to display binding sites heterogeneity and slow diffusion mass transfer of analytes to the imprinted sites affecting their overall performance. Besides, the performance of molecularly imprinted polymers in organic solvents is excellent, but their selective binding ability in aqueous media is considerably reduced. Accordingly, the present review pretends to provide an updated overview of the recent advances and trends of molecularly imprinted polymers‐based extraction, focusing on those strategies proposed for the improvement of mass transfer and selective recognition in aqueous media. Besides, with the progressive implementation of Green Chemistry principles, the different steps and strategies for the preparation of molecularly imprinted polymers are reviewed from a green perspective.

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BioMIPs: molecularly imprinted silk fibroin nanoparticles to recognize the iron regulating hormone hepcidin

Cited by 10 publications

References 41 publications

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Molecularly Imprinted Polymer-Based Biomimetic Systems for Sensing Environmental Contaminants, Biomarkers, and Bioimaging Applications

Recent advances and future trends in molecularly imprinted polymers‐based sample preparation

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