Biomineralization of nanoscale single crystal hydroxyapatite

Omokanwaye, Tiffany; Wilson, Otto C.; Gugssa, Ayelle; Anderson, Winston A.

doi:10.1016/j.msec.2015.05.073

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…TEM images of the extracted samples revealed the biomineralization of the demineralized crab shell implanted. The mineralization induced a mineral phase, mineralized collagen bundles and fibres, and fibroblast as reported in Omokanwaye et al (Omokanwaye et al, 2015). HRTEM micrographs of the mineral regions showed an aggregate of nanoparticles with spots and shape of nanocrystalline characteristics as shown in Figure 1.…”

Section: Re Sultssupporting

confidence: 66%

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Mesocrystal aggregation of biological apatite nanocrystals

Alrebaish

Wilson

2021

Med Devices & Sens

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Bone is a composite structure that is composed of calcium phosphate mineral, type I collagen, water and extracellular matrix proteins that interact over several levels of hierarchy from the macroscale to nanoscale. Early crystallographic studies on bone biominerals identified that they are calcium deficient and carbonate substituted biosynthesized hydroxyapatite (BHAp) (Trautz, 1955;Zapanta-LeGeros, 1965). The shape of the nanocrystals is generally plate-like with particle size in the range of 30-50 nm (length), 10-30 nm (width) and 2-10 nm (thickness) (Heywood et al., 1990;Sakae et al., 2015). The extensive shape and small size of BHAp have triggered high research interest in its mechanism of crystallization in terms of nucleation and growth. Understanding the formation of BHAp in a biological environment is essential for studies in bone healing, remodelling and regeneration and provides a sound foundation for advancing future endeavours in the design of bone biomaterials (Combes et al., 2016).Additional benefits can be derived from these studies in material design related to drug and gene delivery, nutritional supplements, health products and analytical tools to probe nanoscale phenomena such as hydroxyapatite based Quartz Crystal Microbalance (QCM) adsorption systems with enhanced sensitivity (REF).

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Section: Re Sultssupporting

confidence: 66%

“…These data that were analysed in this work were produced from an investigation on the ectopic biomineralization of BHAp in Sprague‐Dawley rats (Omokanwaye et al, 2015). In summary, Carapace integument from Callinectes sapidus (Chesapeake blue crab) specimens was removed and cleaned by deionized water.…”

Section: Methodsmentioning

confidence: 99%

Mesocrystal aggregation of biological apatite nanocrystals

Alrebaish

Wilson

2021

Med Devices & Sens

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Localized Crystallization of Calcium Phosphates by Light‐Induced Processes

Besirske,

Menichetti,

Montalti

et al. 2023

Chemistry A European J

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Medical treatment options for bones and teeth can be significantly enhanced by taking control over the crystallization of biomaterials like hydroxyapatite in the healing process. Light‐induced techniques are particularly interesting for this approach as they offer tremendous accuracy in spatial resolution. However, in the field of calcium phosphates, light‐induced crystallization has not been investigated so far. Here, proof of principle is established to successfully induce carbonate‐hydroxyapatite precipitation by light irradiation. Phosphoric acid is released by a photolabile molecule exclusively after irradiation, combining with calcium ions to form a calcium phosphate in the crystallization medium. 4‐Nitrophenylphosphate (4NPP) is established as the photolabile molecule and the system is optimized and fully characterized. A calcium phosphate is crystallized exclusively by irradiation in aqueous solution and identified as carbonate apatite. Control over the localization and stabilization of the carbonate apatite is achieved by a pulsed laser, triggering precipitation in calcium and 4NPP‐containing gel matrices. The results of this communication open up a wide range of new opportunities, both in the field of chemistry for more sophisticated reaction control in localized crystallization processes and in the field of medicine for enhanced treatment of calcium phosphate containing biomaterials.

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