“…However, enzymes will face harsh conditions, including high temperature, strong acid and alkali, etc., if they are applied directly into the industrial process. Hence, immobilized enzyme, which can improve enzyme stability and recycle several times for industrial process, has been widely used and studied. − Traditional methods are generally immobilizing target enzymes on the pre-existing solid carriers via adsorption, cross-linking, or covalent binding approach. , Recently, biomimetic mineralization has been considered as an outstanding process to fabricate advanced materials with diverse morphologies, − and it is worth mentioning that the gel diffusion is an excellently controllable method for mimetic biomineralization. − Thus, the application of a biomineralization process in enzyme immobilization has gained much attention, because of the particularly mild reaction conditions and ultrahigh enzyme activity recovery. − Moreover, thanks to the mild process of biomineralization, enzyme–inorganic hybrid composites could provide reliable stabilization effect for incorporated enzymes and let them exhibit plentiful biological functions. Currently, the biomineralization of metal phosphates has been proven to be an outstanding approach to synthesize nanobiocatalysts.…”