Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

Xu, Zeqian; Qi, Xuanyu; Bao, Minyue; Zhou, Tian; Shi, Junfeng; Xu, Zhiyan; Zhou, Mingliang; Boccaccını, Aldo R.; Zheng, Kai; Jiang, Xinquan

doi:10.1016/j.bioactmat.2023.01.024

Cited by 22 publications

(18 citation statements)

References 80 publications

(114 reference statements)

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“…Even so, the time was less than what would have been required for a 9-cm extension using only external xation. Furthermore, as our patient was a diabetic whose blood glucose was not monitored, a proin ammatory microenvironment at defect sites with resultant pathology of bone metabolism remained a risk [19,20]. This pathophysiological factor likely prolonged the duration of consolidation during bone segment distraction.…”

Section: Discussionmentioning

confidence: 97%

Use of Ilizarov and MIPPO techniques in the treatment of a 20-year infected nonunion of the tibia: a case report

Niu,

Cui,

Ren

et al. 2023

Preprint

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Introduction: The management of infected nonunion has always been an orthopedic challenge, and it is more difficult to treat it if it is accompanied by shortening and angulation deformity. Case report: we present a case of osteomyelitis and infected nonunion of the right tibia with right lower extremity shortening and angular deformities. The Ilizarov technique was applied to treat large segmental bone defects with deformities via simultaneous lengthening of the free bone segment and the broken distal tibia. Conclusion: Use of the Ilizarov technique in combination with MIPPO can effectively treat bone deformities caused by infected nonunion while reducing the duration of external fixation, protecting against refracture and allowing for early rehabilitation.

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Section: Discussionmentioning

confidence: 97%

Use of Ilizarov and MIPPO techniques in the treatment of a 20-year infected nonunion of the tibia: a case report

Niu,

Cui,

Ren

et al. 2023

Preprint

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“…The performance of methacrylate-based grafting was also observed by other authors. Recently, it was reported that bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles embedded in a gelatin methacrylate matrix present enhanced osteogenic, angiogenic, and immunomodulatory properties [ 36 ]. Furthermore, a novel graphene oxide modified expandable polymethyl methacrylate-based bone cement revealed improved physiochemical properties with sufficient cytocompatible, and osteogenic characteristics [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study

Sigusch

Kranz

Hohenberg

et al. 2023

IJMS

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Recently, our group developed two different polymeric biomaterials with photodynamic antimicrobial surface activity for periodontal bone regeneration. The aim of the present study was to analyze the biocompatibility and osseointegration of these materials in vivo. Two biomaterials based on urethane dimethacrylate (BioM1) and tri-armed oligoester-urethane methacrylate (BioM2) that additionally contained ß-tricalcium phosphate and the photosensitizer mTHPC (meso-tetra(hydroxyphenyl)chlorin) were implanted in non-critical size bone defects in the femur (n = 16) and tibia (n = 8) of eight female domestic sheep. Bone specimens were harvested and histomorphometrically analyzed after 12 months. BioM1 degraded to a lower extent which resulted in a mean remnant square size of 17.4 mm², while 12.2 mm² was estimated for BioM2 (p = 0.007). For BioM1, a total percentage of new formed bone by 30.3% was found which was significant higher compared to BioM2 (8.4%, p < 0.001). Furthermore, BioM1 was afflicted by significant lower soft tissue formation (3.3%) as compared to BioM2 (29.5%). Additionally, a bone-to-biomaterial ratio of 81.9% was detected for BioM1, while 8.5% was recorded for BioM2. Implantation of BioM2 caused accumulation of inflammatory cells and led to fibrous encapsulation. BioM1 (photosensitizer-armed urethane dimethacrylate) showed favorable regenerative characteristics and can be recommended for further studies.

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“…Mesoporous silica nanoparticles (MSNPs) are silica-based nanoparticles with a porous structure, allowing for the encapsulation and controlled release of therapeutic agents. , Integrating Sr-doped mesoporous bioactive glass nanoparticles (Sr-MBGNs) (0.1%) into GelMA (5%) hydrogel has enabled the fabrication of 3D-printed nanocomposite bioscaffolds, which effectively emulate the pathologic diabetic micromilieu . The Sr-MBGNs facilitate biomineralization with remarkable angiogenetic and anti-inflammatory properties by releasing Sr, Ca, and Si ions from the composite scaffolds.…”

Section: Modulating Scaffold Properties Through Gelma Ink Modificationsmentioning

confidence: 99%

“…445,446 Integrating Sr-doped mesoporous bioactive glass nanoparticles (Sr-MBGNs) (0.1%) into GelMA (5%) hydrogel has enabled the fabrication of 3D-printed nanocomposite bioscaffolds, which effectively emulate the pathologic diabetic micromilieu. 447 The Sr-MBGNs facilitate biomineralization with remarkable angiogenetic and anti-inflammatory properties by releasing Sr, Ca, and Si ions from the composite scaffolds. Additionally, the nanocomposite scaffold activates lysyl oxidase, thereby promoting cell adhesion, enhancing the release of osteocalcin, and modulating osteoblast differentiation via the Kindlin-2/ PTH1R/OCN axis.…”

mentioning

confidence: 99%

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Das,

Jegadeesan,

Basu

2024

Biomacromolecules

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Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, and there has been considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly in the area of biomaterial selection for these applications as well as quantitative understanding of the process science. The strategic utilization of biological macromolecules provides a versatile approach to meet diverse requirements in 3D printing, such as printability, buildability, and biocompatibility. These molecules play a pivotal role in both physical and chemical cross-linking processes throughout the biofabrication, contributing significantly to the overall success of the 3D printing process. Among the several bioprintable materials, gelatin methacryloyl (GelMA) has been widely utilized for diverse tissue engineering applications, with some degree of success. In this context, this review will discuss the key bioengineering approaches to identify the gelation and cross-linking strategies that are appropriate to control the rheology, printability, and buildability of biomaterial inks. This review will focus on the GelMA as the structural (scaffold) biomaterial for different tissues and as a potential carrier vehicle for the transport of living cells as well as their maintenance and viability in the physiological system. Recognizing the importance of printability toward shape fidelity and biophysical properties, a major focus in this review has been to discuss the qualitative and quantitative impact of the key factors, including microrheological, viscoelastic, gelation, shear thinning properties of biomaterial inks, and printing parameters, in particular, reference to 3D extrusion printing of GelMA-based biomaterial inks. Specifically, we emphasize the different possibilities to regulate mechanical, swelling, biodegradation, and cellular functionalities of GelMA-based bio(material) inks, by hybridization techniques, including different synthetic and natural biopolymers, inorganic nanofillers, and microcarriers. At the close, the potential possibility of the integration of experimental data sets and artificial intelligence/machine learning approaches is emphasized to predict the printability, shape fidelity, or biophysical properties of GelMA bio(material) inks for clinically relevant tissues.

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

Cited by 22 publications

References 80 publications

Use of Ilizarov and MIPPO techniques in the treatment of a 20-year infected nonunion of the tibia: a case report

Use of Ilizarov and MIPPO techniques in the treatment of a 20-year infected nonunion of the tibia: a case report

Histological and Histomorphometric Evaluation of Implanted Photodynamic Active Biomaterials for Periodontal Bone Regeneration in an Animal Study

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

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