Biomimetische Fluorapatit‐Gelatine‐Nanokomposite: Vorstrukturierung von Gelatine‐Matrices durch Ionenimprägnierung und Auswirkungen auf die Formentwicklung

Abstract

Die Form folgt aus dem Ion: Die Auswirkungen von Ionenimprägnierung der organischen Komponente auf den Wachstumsmechanismus und die Morphogenese von Fluorapatit‐Gelatine‐Nanokompositen wurden durch Elektronenmikroskopie und atomistische Simulationen untersucht. In Abhängigkeit von der Ionensorte konnten dabei drastische Veränderungen der mesoskopischen Strukturierung beobachtet werden.

A Molecular Rationale of Shock Absorption and Self‐Healing in a Biomimetic Apatite–Collagen Composite under Mechanical Load

“…[8][9][10][11] We expect the well-defined structure illustrated in Figure 1 (left) to play a key role in dividing sacrificial and intact regions in the composite.…”

“…[8] This biomimetic composite exhibits important similarities to enamel prisms (hierarchical structure, 2 wt % protein content) and should hence offer qualitative understanding of the more complex biomineral. Moreover, the interplay of experimental characterization and atomistic simulation provided a very detailed picture of the biomimetic composite, [9,10] and recently led to the creation of a nanometer-sized simulation model mimicking an apatite-collagen composite at the atomic level. [11] For the present study, this model was further extended to encompass a hexagonal pattern of collagen molecules (approximated by (Hyp-Pro-Gly) n , see also references [9,10]) embedded into 20 20 10 unit cells of apatite.…”

Functional Hybrid Materials with Polymer Nanoparticles as Templates

“…[25,26] The intrinsic biocompatibility, ability to interact with hydroxyapatite (HAP) mineral surfaces, and its low cost makes it an interesting candidate for the biomimetic mineralization of CaP for use in tissue-engineering applications. Gelatin is basically a proteinaceous polyampholytic gel obtained by the partial hydrolysis (acidic or basic) of collagen.…”

Fluorapatite–Gelatine Nanocomposite Superstructures: New Insights into a Biomimetic System of High Complexity

“…% gelatine) are characterized by a fractal or fan-like growth mechanism starting with a central hexagonal-prismatic seed. [5] The seed represents a nanocomposite superstructure (~10-15 nm) that consists of self-similar subunits (nanorods, 10-15 nm in diameter and~300-350 nm in length) arranged in a close packing. [1] The nanorods are nucleated at, and subsequently grown around, the triple-helical fiber protein macromolecules.…”

“…Taking into account the experimental evidence for the presence of an electrical potential around the seed, the orientation of the microfibrils can be assumed to be controlled by the intrinsic electric field that is generated by the composite during its development and growth. [8,9] Based on the experimental findings [5][6][7][8][9] we started to mimic the formation and 3D distribution of the fibril pattern inside the nanocomposite seed by development of a suitable simulation model generated by a collection of dipole elements (socalled A-units), which are composed of rigid point dipoles (a-dipoles) located on a hexagonal prismatic grid. [10] The Aunits represent hexagonal-prismatic elementary building blocks corresponding to the abovementioned nanorods with the embedded triple-helices at their centers.…”