Biomimetic tri-layered artificial skin comprising silica gel-collagen membrane-collagen porous scaffold for enhanced full-thickness wound healing

Tian, Jing; Fu, Caihong; Li, Wenhua; Li, Na; Yao, Linyan; Xiao, Jianxi

doi:10.1016/j.ijbiomac.2024.131233

Cited by 2 publications

(2 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…Extensive cutaneous wounds are often accompanied by delayed healing and even bring about systemic complications due to the impaired anti-infectious capacity of the destroyed skin barrier. 1 The common treatment for skin wounds is the combined application of wound dressings and antimicrobial agents. However, the widely used traditional dressings such as gauze usually serve as a physical barrier to protect the wounds from external contamination but cannot function in response to different stages of the injury healing process, thereby failing to accelerate the wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Metal–Polyphenol–Collagen Self-Assembled Bioadhesive with Immune Regulation for Infected Wound Healing

Zhao,

Yan,

et al. 2024

ACS Appl. Polym. Mater.

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Destroyed skin barriers for extensive cutaneous wounds often bring about delayed healing and even systemic complications. Multifunctional dressing materials targeting different stages of the healing process have drawn growing concerns to obtain desirable tissue repair. In this study, a self-assembled collagen/tannic acid− zinc (ColTA-Zn) bioadhesive powder with a dual cross-linking network was developed for infected wound healing. The hydrogen bonds between collagen chains and tannic acid, together with the metal coordination formed by Zn 2+ and tannic acid, mainly contribute to the adhesion performances and mechanical properties of the bioadhesive. Furthermore, the biocompatible ColTA-Zn powder exerts antimicrobial effects on Staphylococcus aureus. Crucially, the ColTA-Zn powder can absorb blood or exudate quickly along with a rapid gelation and adhere to the wound surface once contacting the wounds, playing the roles of adsorption, convergence, and adhesion. During the healing process, the self-gelled ColTA-Zn dressing exhibits an immunomodulatory effect on macrophage polarization and ultimately accelerates wound healing. Therefore, the self-assembled, accessible, and userfriendly ColTA-Zn adhesive might be a potential candidate for wound dressings with adhesive, anti-infectious, and conglutinant functions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%