Biomimetic total synthesis and paired omics identify an intermolecular Diels-Alder reaction as the key step in lugdunomycin biosynthesis
Michiel T. Uiterweerd,
Isabel Nunez Santiago,
Remco Havenith
et al.
Abstract:Microbial natural products are the basis of the majority of the clinical drugs, such as antibiotics, anticancer agents, antifungals and immunosuppressants. The sharp rise in antimicrobial resistance (AMR) requires new ways to replenish the drug-discovery pipelines, whereby the discovery of truly novel structural scaffolds is a major challenge. Lugdunomycin is a highly rearranged angucycline polyketide produced by Streptomyces sp. QL37, but the later stages of its biosynthesis so far remained elusive. Here, usi… Show more
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