Biomimetic Synthesis of Inorganic Nanospheres

Jan, Jeng‐Shiung; Lee, Seungju; Carr, C. S.; Shantz, Daniel F.

doi:10.1021/cm0504440

Cited by 97 publications

(84 citation statements)

References 59 publications

(93 reference statements)

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“…[25] The latter point is consistent with previous work from our lab. [29] Also consistent with previous work is that the Lys- ) are absent. Figure 1 shows the FE-SEM images of silicas formed in the presence of Lys 340 -b-Gly 85 and Lys 320 -b-Gly 160 for each of the three synthesis methods.…”

supporting

confidence: 91%

“…This was observed in our previous work with Lys-Phe polymers possessing high Lys:Phe ratios. [29] In the case of the most kinetically trapped vesicles we have made to date (1:1 Phe-Lys polymers) the vesicles were so robust that hollow spheres were formed. These are not observed for any of the syntheses reported here.…”

mentioning

confidence: 98%

“…[27,28] Second, we have shown that individual supramolecular objects (vesicles) formed by block copolypeptides can be used as templates to form nanostructured hard materials. [29] In the latter case the block copolypeptides studied were Lys-b-Phe block copolypeptides that form kinetically trapped structures in solution. Here we report the formation of silicas in the presence of a series of block copolypeptides, but mainly Lys-b-Gly block copolypeptides which appear to form more reversible structures as compared to the materials we reported previously.…”

mentioning

confidence: 99%

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Biomimetic Silica Formation: Effect of Block Copolypeptide Chemistry and Solution Conditions on Silica Nanostructure

Jan

Shantz

2007

Advanced Materials

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Developing new technologies as a consequence of controlling structure, chemistry, and functionality at the nanometer length scale is the ultimate goal of nanotechnology. One route to this goal is to draw lessons from nature, which has developed the ability to fabricate inorganic and inorganic-hybrid materials such as silica diatoms and nacre that have properties that the materials science community can only aspire to achieve. [1][2][3][4][5][6][7] The development of so-called biomimetic or bioinspired synthesis methods to develop hard matter with new or unusual properties has become an area of tremendous growth. One aspect of this problem is the synthesis of silica materials using amines or polyamines under ambient conditions. Numerous works have demonstrated materials with unusual properties, particularly with respect to morphology and microstructure. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Of particular relevance to the current work are the numerous reports of silicas made in the presence of poly-L-lysine. From this body of literature it is clear that one can make silicas with various morphologies through manipulation of pH, salt, flow versus quiescent conditions, etc. Further, recent works from several labs have shown the poly-L-lysine chain conformation can be used to control silica morphology. [25,26] It is this point in particular that is explored in the current investigation. Our lab has made two contributions to this blossoming area. First, we have demonstrated that the conformation of polypeptide chains can be used to manipulate the porosity of the oxide obtained. [27,28] Second, we have shown that individual supramolecular objects (vesicles) formed by block copolypeptides can be used as templates to form nanostructured hard materials. [29] In the latter case the block copolypeptides studied were Lys-b-Phe block copolypeptides that form kinetically trapped structures in solution. Here we report the formation of silicas in the presence of a series of block copolypeptides, but mainly Lys-b-Gly block copolypeptides which appear to form more reversible structures as compared to the materials we reported previously. This manuscript reports on how the polypeptide chemistry and solution conditions influence both the morphology and porosity of the hard material they assemble. This latter point has been sparingly studied, yet for many applications this property will be essential. In all cases the block copolypeptides investigated here form supramolecular structures in solution, typically vesicles. However, the Lys-b-Gly block copolypeptides form structures that appear to be more reversible in nature as compared to the objects formed by the Lys-b-Ala and Lys-b-Phe block copolypeptides that appear to be kinetically trapped structures. The critical aggregation concentrations for the polymers studied below are given in the supporting information and are between 0.8-1.7 lM. The syntheses described below use between 3.0-4.0 lM solutions (Methods II, III) or 9.0-10.0 lM solutions (Method I), a...

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supporting

confidence: 91%

mentioning

confidence: 98%

mentioning

confidence: 99%

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Biomimetic Silica Formation: Effect of Block Copolypeptide Chemistry and Solution Conditions on Silica Nanostructure

Jan

Shantz

2007

Advanced Materials

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“…Polymer Vesicles -Polymer Crosslinking [124] -Polymeric Micelles [125] Lipid Vesicles -Nanosized Liposome [126] Charged Polypeptide -Peptide Crosslinking [127] Inorganic Vesicles -Inorganic Synthesis [128] Receptor T/B Cell ReceptorNK Cell ReceptorImmune Signaling ComplexNeurotransmitter ReceptorIntegrin…”

Section: Typementioning

confidence: 99%

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

et al. 2010

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It is becoming increasingly evident that cell biology research can be considerably advanced through the use of bioengineered tools enabled by nanoscale technologies. Recent advances in nanopatterning techniques pave the way for engineering biomaterial surfaces that control cellular interactions from the nano- to the microscale, allowing more precise quantitative experimentation capturing multi-scale aspects of complex tissue physiology in vitro. The spatially and temporally controlled display of extracellular signaling cues on nanopatterned surfaces (e. g., cues in the form of chemical ligands, controlled stiffness, texture, etc.) that can now be achieved on biologically relevant length scales is particularly attractive enabling experimental platform for investigating fundamental mechanisms of adhesion-mediated cell signaling. Here, we present an overview of bio-nanopatterning methods, with the particular focus on the recent advances on the use of nanofabrication techniques as enabling tools for studying the effects of cell adhesion and signaling on cell function. We also highlight the impact of nanoscale engineering in controlling cell-material interfaces, which can have profound implications for future development of tissue engineering and regenerative medicine.

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“…Diatom cells are beautifully elaborate silica shells that have nanoscale hooks, holes and gorges that are believed to be formed by a fibrous protein core [64,65]. Indeed, it has been previously shown that fibrous proteins can mediate templating of tetraethyl orthosilicate to form silica [66 - and that arginine and lysine play an important role in the templating process [67][68][69]. In recent work, we used the library of variants of the sequence 'KFFEAAAKKFFE' to explore whether these fibrils can form silica wires and how the sequence contributes to the morphology of the resulting structures.…”

Section: Decorating the Exterior Of Amyloid Fibrilsmentioning

confidence: 99%

The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides

et al. 2017

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Amyloidogenic peptides are well known for their involvement in diseases such as type 2 diabetes and Alzheimer's disease. However, more recently, amyloid fibrils have been shown to provide scaffolding and protection as functional materials in a range of organisms from bacteria to humans. These roles highlight the incredible tensile strength of the cross-β amyloid architecture. Many amino acid sequences are able to self-assemble to form amyloid with a cross-β core. Here we describe our recent advances in understanding how sequence contributes to amyloidogenicity and structure. For example, we describe penta- and hexapeptides that assemble to form different morphologies; a 12mer peptide that forms fibrous crystals; and an eight-residue peptide originating from α-synuclein that has the ability to form nanotubes. This work provides a wide range of peptides that may be exploited as fibrous bionanomaterials. These fibrils provide a scaffold upon which functional groups may be added, or templated assembly may be performed.

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Biomimetic Synthesis of Inorganic Nanospheres

Cited by 97 publications

References 59 publications

Biomimetic Silica Formation: Effect of Block Copolypeptide Chemistry and Solution Conditions on Silica Nanostructure

Biomimetic Silica Formation: Effect of Block Copolypeptide Chemistry and Solution Conditions on Silica Nanostructure

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides

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