Biomimetic synthesis of coexistence of vaterite-calcite phases controlled by histidine-grafted-chitosan

Chen, Zhangxu; Xin, Meihua; Li, Mingchun; Xu, Jianpeng; Li, Xianxue; Chen, Xiao

doi:10.1016/j.jcrysgro.2014.07.008

Cited by 15 publications

(7 citation statements)

References 35 publications

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“…Materials. Imidazole-4,5-dicarboxylic acid grafted chitosan (IDACS) is synthesized according to our previous reports [20][21][22]. Disodium hydrogen phosphate and (Na 2 HPO 4 ), absolute ethanol (C 2 H 5 OH), calcium chloride (CaCl 2 ), hydrochloric acid (HCl), and ammonia (NH 3 ·H 2 O) are all of analytical reagent and are all purchased from Aladdin Reagent Co., Ltd. (China), which are used as starting materials without further purification.…”

Section: Methodsmentioning

confidence: 99%

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Biomimetic Synthesis of Hydroxyapatite in Presence of Imidazole-4,5-dicarboxylic Acid Grafted Chitosan for Removing Chromium(VI)

Chen

Huang

et al. 2018

Journal of Nanotechnology

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In order to biomimetic synthesize hydroxyapatite similar to natural bone. Hydroxyapatite (HAP) is biomimetic synthesized in simulated body fluid (SBF) by addition of imidazole-4,5-dicarboxylic acid grafted chitosan (IDACS). e effect of molar ratio of chitosan (CS) to imidazole-4,5-dicarboxylic acid (IDA) on preparation of HAP was investigated. e structure, size, and crystal phase of the obtained hydroxyapatite were observed by Fourier transform infrared spectroscopy, X-ray powder diffraction, and scanning electron microscopy. e results show that the molar ratio of CS to IDA is 1 : 3, the temperature is 37.0°C, the aging time is 48 h, the synthesized nanorod-like hydroxyapatite with diameter 20-30 nm, and length ranging from 75 to 120 nm presents excellent phase, which disperses well and is similar to the natural bone of HAP. e obtained HAP can be used to remove chromium(VI) by the orthogonal experiments, and the results indicated that the removal rate can reach 95.66% under the optimum conditions. ese results suggest that the morphology of the obtained HAP is more affected by the material ratio of chitosan to imidazole-4,5-dicarboxylic acid than its structure, and the obtained HAP can effectively remove Cr(VI), which provides a novel method for biomimetic synthesis of other biomaterials and application in the water purification.

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Section: Methodsmentioning

confidence: 99%

“…In our previous research, a series of biological materials, such as calcium carbonate and hydroxyapatite have also been successfully fabricated by using the method of biomimetic synthesis [8,20,21]. Encouraged by this, herein, a rational design to biomimetic synthesize hydroxyapatite for removing Cr(VI) was firstly proposed.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Synthesis of Hydroxyapatite in Presence of Imidazole-4,5-dicarboxylic Acid Grafted Chitosan for Removing Chromium(VI)

Chen

Huang

et al. 2018

Journal of Nanotechnology

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“…Minerals formed in all WPI hydrogels containing urease, displaying peaks at 23.2, 29.5, 36.1, 39.5, 43.3, 47.7, 48.6 and 57.5, which are characteristic for calcite [13,25]. In addition, WPI_U_MA hydrogels displayed peaks characteristic for vaterite at 24.9, 27.0 and 32.8 [26]. A peak near 30 degrees in WPI_U_MC hydrogels may indicate the presence of calcium magnesium carbonate.…”

Section: Physicochemical Characterization Of Mineral Formed By Ftir Raman Xrd and Semmentioning

confidence: 98%

Marine-Inspired Enzymatic Mineralization of Dairy-Derived Whey Protein Isolate (WPI) Hydrogels for Bone Tissue Regeneration

et al. 2020

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Whey protein isolate (WPI) is a by-product from the production of cheese and Greek yoghurt comprising β-lactoglobulin (β-lg) (75%). Hydrogels can be produced from WPI solutions through heating; hydrogels can be sterilized by autoclaving. WPI hydrogels have shown cytocompatibility and ability to enhance proliferation and osteogenic differentiation of bone-forming cells. Hence, they have promise in the area of bone tissue regeneration. In contrast to commonly used ceramic minerals for bone regeneration, a major advantage of hydrogels is the ease of their modification by incorporating biologically active substances such as enzymes. Calcium carbonate (CaCO3) is the main inorganic component of the exoskeletons of marine invertebrates. Two polymorphs of CaCO3, calcite and aragonite, have shown the ability to promote bone regeneration. Other authors have reported that the addition of magnesium to inorganic phases has a beneficial effect on bone-forming cell growth. In this study, we employed a biomimetic, marine-inspired approach to mineralize WPI hydrogels with an inorganic phase consisting of CaCO3 (mainly calcite) and CaCO3 enriched with magnesium using the calcifying enzyme urease. The novelty of this study lies in both the enzymatic mineralization of WPI hydrogels and enrichment of the mineral with magnesium. Calcium was incorporated into the mineral formed to a greater extent than magnesium. Increasing the concentration of magnesium in the mineralization medium led to a reduction in the amount and crystallinity of the mineral formed. Biological studies revealed that mineralized and unmineralized hydrogels were not cytotoxic and promoted cell viability to comparable extents (approximately 74% of standard tissue culture polystyrene). The presence of magnesium in the mineral formed had no adverse effect on cell viability. In short, WPI hydrogels, both unmineralized and mineralized with CaCO3 and magnesium-enriched CaCO3, show potential as biomaterials for bone regeneration.

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“…Therefore, dendritic cell membrane (DCM)-mediated vaccines with small sizes (20–200 nm) presumably could drain to lymph nodes and target lymph node DCs. Histidine is very important for the biological function, can be rapidly protonated in slight acidic surroundings, and shows strong pH-responsive capability, which indicate that antigen-delivery vectors modified with histidine presumably could promote lysosomal escape of antigens to induce cellular immunity.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Many types of cellderived membranes can be used to improve nanoparticle delivery, 12−15 and nanoparticles encapsulated with the cell membrane exhibited specific homologous targeting to homologous cells. 16 Therefore, dendritic cell membrane (DCM)-mediated vaccines with small sizes (20−200 shows strong pH-responsive capability, 17 which indicate that antigen-delivery vectors modified with histidine presumably could promote lysosomal escape of antigens to induce cellular immunity.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Biomimetic Polymeric Micelles as Lymph Node-Targeting Vaccines for Enhanced Antitumor Immune Responses

Yang

Zeng

et al. 2020

Biomacromolecules

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Lymph nodes are proposed as the intriguing target in cancer immunotherapy, and cellular immunity is vital for vaccines to fight against cancer. However, inefficient delivery of vaccines to lymph nodes and deficient lysosomal escape of antigens result in weak cellular immunity, which restrains the strength of vaccines in inducing antitumor immune responses. Hence, dendritic cell membrane (DCM)/histidine-modified stearic acid-grafted chitosan (HCtSA)/ovalbumin (OVA) micelles, as pH-responsive biomimetic vaccines, were fabricated to target lymph nodes and induce cellular immunity for enhanced antitumor immune responses. DCM/HCtSA/OVA micelles exhibited pH-dependent antigen release behavior, which resulted in efficient escape of antigens from dendritic cell (DC) lysosomes. Besides, DCM/ HCtSA/OVA micelles accumulated and reserved in the lymph nodes, which ensured effective uptake by DCs. Importantly, DCM/HCtSA/OVA micelles induced potent T cell immune responses, promoted secretion of antitumorrelated cytokines, and notably inhibited tumor growth. Overall, DCM/HCtSA/OVA micelles exhibit great potential in targeted immunotherapy and can provide guidance for the design of vaccines.

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Biomimetic synthesis of coexistence of vaterite-calcite phases controlled by histidine-grafted-chitosan

Cited by 15 publications

References 35 publications

Biomimetic Synthesis of Hydroxyapatite in Presence of Imidazole-4,5-dicarboxylic Acid Grafted Chitosan for Removing Chromium(VI)

Biomimetic Synthesis of Hydroxyapatite in Presence of Imidazole-4,5-dicarboxylic Acid Grafted Chitosan for Removing Chromium(VI)

Marine-Inspired Enzymatic Mineralization of Dairy-Derived Whey Protein Isolate (WPI) Hydrogels for Bone Tissue Regeneration

pH-Responsive Biomimetic Polymeric Micelles as Lymph Node-Targeting Vaccines for Enhanced Antitumor Immune Responses

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