Biomimetic surface modification of discoidal polymeric particles

Nguyen, Tuyen Duong Thanh; Aryal, Susmita; Pitchaimani, Arunkumar; Park, Sang-hyo; Key, Jaehong; Aryal, Santosh

doi:10.1016/j.nano.2018.11.011

Cited by 23 publications

(18 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Curcumin loaded discoidal polymeric particles (DPPs) were fabricated by the top-down fabrication method using an electron beam lithography technique [18][19][20]. Briefly, a silicon master template with an array of discoidal wells was purchased from the Korea Infrastructure Organization for Nanotechnology, South Korea.…”

Section: Fabrication Process Of Porous and Non-porous Discoidal Polymeric Particlesmentioning

confidence: 99%

Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

Aryal

Park

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

Curcumin has great potential in cancer treatment and prevention. However, free curcumin for anticancer effect is limited due to its low water solubility and instability. Delivery of free curcumin using biodegradable and biocompatible polymers, such as poly (lactic-co-glycolic acid) (PLGA), can improve these undesirable problems. In this study, a top-down fabrication method using PLGA was employed to deliver free curcumin, engineering size, shape, and surface properties. As a result, porous discoidal polymeric particles (DPPs) were produced in ammonium bicarbonate with a hydrodynamic diameter of 5 mm and a negatively charged surface. The loading amount of free curcumin in the porous DPPs was higher than non-porous DPPs. In vitro drug release study showed that curcumin release from porous DPPs was 1.4-fold higher than non-porous ones. The confocal microscopy and flow cytometry results demonstrated that porous DPPs decrease phagocytosis by macrophages than non-porous ones. This study suggests that porous DPPs have significant advantages for effective drug delivery of curcumin, minimizing phagocytosis.

show abstract

Section: Fabrication Process Of Porous and Non-porous Discoidal Polymeric Particlesmentioning

confidence: 99%

Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

Aryal

Park

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

Self Cite

View full text Add to dashboard Cite

show abstract

“…PLGA with the carboxylic acid terminated end group of molecular weight 50 kDa was used to synthesize LyP-1NP following the wellestablished nanoprecipitation protocol. [34][35][36][37][38] In a typical experiment, 1 mg mL À1 PLGA in 400 mL acetonitrile was used to prepare the nanoparticles. The second component is phospholipids that consist of lipid mixture formulations having 250 mg of DSPE-PEG, 200 mg DSPG, and 10 mg LyP-1-DSPE-PEG, which were used in 4% ethanol, respectively.…”

Section: Preparation Of Lyp-1 Conjugated Multifunctional Lipid-polymementioning

confidence: 99%

“…This dose of dye was chosen based on the literature. 18,35,36,45 The solid tumor model using osteosarcoma cancer cells was developed by subcutaneous injection of 1 Â 10 6 K7M2 cells into the rear flank of an immunodeficient NU/NU nude mouse (Charles River, 088/NU/NU homozygous). After 1 week of tumor induction or when the tumor size reaches about 6 mm 3 , tumor-bearing animals were treated with the respective NPs for the biodistribution studies.…”

Section: Biodistribution and In Vivo Imagingmentioning

confidence: 99%

“…DiR dye was labeled with NPs according to the published protocol to obtain DiR labeled NPs. 18,35,36 After a single dose post-injection of 10 mg kg À1 of NPs via the lateral tail vein (100 mL volume), mice (n = 3) were imaged to map the real-time distribution of NPs at various time points viz., 0.5, 1, 2, 3, 6, 12, 24, and 48 h. The non-invasive imaging of mice was performed after anaesthetizing (2-3% isoflurane in 100% oxygen) and placing them on a preheated bed (plate). The 750 nm channel was used to excite DiR and emission was observed at 800 nm.…”

Section: Biodistribution and In Vivo Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and characterization of a tumor-seeking LyP-1 peptide integrated lipid–polymer composite nanoparticle

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Specifically referring to cell membrane‐based nanomedicines, it appears that through the marriage of the physical properties of nanomaterials with the natural biointerfacing capabilities of the cell membrane, new therapeutics can be engineered to possess multimodal functionalities including the ability to differentiate cancer cells from healthy cells, effectively delivering a payload or alternative killing modality to the target site, and reducing nonspecific toxicity coupled with the ability to evade the immune system. [ 4–7 ]…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy

Sevencan

McCoy

Ravisankar

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

Over the last decade, researchers have focused on developing an ideal cancer nanomedicine with robust biointerfacing, precise tumor targeting, and effective tumor killing ability. While synthetic approaches have been widely investigated, cell membrane nanotechnology has been attracting growing interest in the nanomedicine field since it enables researchers to exploit the various functions of cells. Prior to development of cell membrane nanotechnology, synthetic cell membrane‐like structures had been employed in nanomedicine. In this review, first a brief comparison between cell membrane and cell membrane‐like structures is provided and the generalized structure and functions of cell membrane are summarized. Cell membrane extraction methods and cell membrane‐based nanoparticle synthesis methods are explained. In addition, applications of these nanotechnologies in many biomedical applications are reviewed. Finally, a perspective of the future prospects and limitations of cell membrane nanotechnology is given. As with many new technologies, there are issues, which when overcome, can allow the potential of cell membrane nanotechnology for future personalized cancer nanomedicine.

show abstract

Biomimetic surface modification of discoidal polymeric particles

Cited by 23 publications

References 52 publications

Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis

Synthesis and characterization of a tumor-seeking LyP-1 peptide integrated lipid–polymer composite nanoparticle

Cell Membrane Nanotherapeutics: From Synthesis to Applications Emerging Tools for Personalized Cancer Therapy

Contact Info

Product

Resources

About