Biomimetic strategies for the deputization of proteoglycan functions
Ibrahim F. Rehan,
Asmaa Elnagar,
František Zigo
et al.
Abstract:Proteoglycans (PGs), which have glycosaminoglycan chains attached to their protein cores, are essential for maintaining the morphology and function of healthy body tissues. Extracellular PGs perform various functions, classified into the following four categories: i) the modulation of tissue mechanical properties; ii) the regulation and protection of the extracellular matrix; iii) protein sequestration; and iv) the regulation of cell signaling. The depletion of PGs may significantly impair tissue function, enc… Show more
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