Biomimetic strategies for targeted nanoparticle delivery

Dehaini, Diana; Fang, Ronnie H.; Zhang, Liangfang

doi:10.1002/btm2.10004

Cited by 131 publications

(101 citation statements)

References 210 publications

(368 reference statements)

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“…In the medical field, the impact of ‘bio-inspired design’ is realized in the areas of cellular engineering, tissue engineering, regenerative medicine, drug delivery and nanomedicine, and a variety of materials engineering to simulate extracellular matrix components. 1-3 A unique area of bio-inspired design that has generated significant academic and clinical research interest during past 30 years is that of bio-inspired nano-scale and micro-scale engineering of synthetic (or semi-synthetic) blood cells using a variety of biomaterials-based systems. The central driving force for this research is to develop technologies that can simulate the structure and/or property of blood cells as well as plasma, to allow utilization of these technologies as ‘blood substitute’ when donor-derived blood is either not readily available or poses significant contamination risks.…”

Section: A Introductionmentioning

confidence: 99%

Bio‐inspired nanomedicine strategies for artificial blood components

Gupta

2017

WIREs Nanomed Nanobiotechnol

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Blood is a fluid connective tissue where living cells are suspended in non-cellular liquid matrix. The cellular components of blood render gas exchange (RBCs), immune surveillance (WBCs) and hemostatic responses (platelets), and the non-cellular components (salts, proteins etc.) provide nutrition to various tissues in the body. Dysfunction and deficiencies in these blood components can lead to significant tissue morbidity and mortality. Consequently, transfusion of whole blood or its components is a clinical mainstay in the management of trauma, surgery, myelosuppression and congenital blood disorders. However, donor-derived blood products suffer from issues of shortage in supply, need for type matching, high risks of pathogenic contamination, limited portability and shelf-life, and a variety of side-effects. While robust research is being directed to resolve these issues, a parallel clinical interest has developed towards bioengineering of synthetic blood substitutes that can provide blood’s functions while circumventing the above problems. Nanotechnology has provided exciting approaches to achieve this, using materials engineering strategies to create synthetic and semi-synthetic RBC substitutes for enabling oxygen transport, platelet substitutes for enabling hemostasis and WBC substitutes for enabling cell-specific immune response. Some of these approaches have further extended the application of blood cell-inspired synthetic and semi-synthetic constructs for targeted drug delivery and nanomedicine. The current article will provide a comprehensive review of the various nanotechnology approaches to design synthetic blood cells, along with a critical discussion of successes and challenges of the current state-of-art in this field.

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Section: A Introductionmentioning

confidence: 99%

Bio‐inspired nanomedicine strategies for artificial blood components

Gupta

2017

WIREs Nanomed Nanobiotechnol

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“…1,2 In the past decade, research within the fields of nanomedicine has demonstrated that nanodrug delivery systems could substantially improve drug bioavailability and local concentration by preventing premature degradation, controlled release, and enhanced permeability and retention effect. 3,4 However, rapid systemic elimination and unspecific and burst release are still major concerns that limit clinical potential of nanomedicine. To optimize nanodrug delivery system, design, and development of multivalent nanoparticles by surface conjugation of bioactive targeting moieties, stimuliresponsive monomers and anti-adsorptive copolymer blocks have been reported.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach

Lou¹,

Zhang²,

Zhang³

et al. 2017

IJN

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A reductase-cleavable and thermo-responsive star-shaped polymer nanogel was prepared via an “arm-first” atom transfer radical polymerization approach. The nanogel consists of a thermo- and redox-sensitive core and a zwitterionic copolymer block. The dual sensitive core is composed of poly(N-isopropylacrylamide) that is formed by disulfide crosslinking of N-isopropylacrylamide. The zwitterionic copolymer block contains a poly(sulfobetaine methacrylate) component, a known anti-adsorptive moiety that extends blood circulation time, and a lactose motif of poly(2-lactobionamidoethyl methacrylamide) that specifically targets the asialoglycoprotein receptors (ASGP-Rs) of hepatoma. Doxorubicin (DOX) was encapsulated into the cross-linked nanogels via solvent extraction/evaporation method and dialysis; average diameter of both blank and DOX-loaded nanogels was ~120 nm. The multi-responsiveness of nanogel drug release in different temperatures and redox conditions was assessed. After 24 h, DOX release was only ~20% at 30°C with 0 mM glutathione (GSH), whereas over 90% DOX release was observed at 40°C and 10 mM GSH, evidence of dual responsiveness to temperature and reductase GSH. The IC 50 value of DOX-loaded nanogels was much lower in human hepatoma (HepG2) cells compared to non-hepatic HeLa cells. Remarkably, DOX uptake of HepG2 cells differed substantially in the presence and absence of galactose (0.31 vs 1.42 µg/mL after 48 h of incubation). The difference was non-detectable in HeLa cells (1.21 vs 1.57 µg/mL after 48 h of incubation), indicating that the overexpression of ASGP-Rs leads to the DOX-loaded lactosylated nanogels actively targeting hepatoma. Our data indicate that the lactose-decorated star-shaped nanogels are dual responsive and hepatoma targeted, and could be employed as hepatoma-specific anti-cancer drug delivery vehicle for cancer chemotherapy.

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“…One way in which biomimetic design can enhance the utility of nanoparticle technology is by enabling targeted delivery through the use of natural ligands . A prominent example is arginylglycylaspartic acid (RGD), which is a binding peptide that can be found in fibronectin .…”

Section: Biomimetic Nanoparticle Technologymentioning

confidence: 99%

Biomimetic Nanotechnology toward Personalized Vaccines

et al. 2019

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While traditional approaches for disease management in the era of modern medicine have saved countless lives and enhanced patient well‐being, it is clear that there is significant room to improve upon the current status quo. For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens that do not respond to most approved drugs. In the field of cancer treatment, the idea of a cure‐all silver bullet has long been abandoned. As a result of the challenges facing current treatment and prevention paradigms in the clinic, there is an increasing push for personalized therapeutics, where plans for medical care are established on a patient‐by‐patient basis. Along these lines, vaccines, both against bacteria and tumors, are a clinical modality that could benefit significantly from personalization. Effective vaccination strategies could help to address many challenging disease conditions, but current vaccines are limited by factors such as a lack of potency and antigenic breadth. Recently, researchers have turned toward the use of biomimetic nanotechnology as a means of addressing these hurdles. Recent progress in the development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed, with an emphasis on their potential for personalized medicine.

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Biomimetic strategies for targeted nanoparticle delivery

Cited by 131 publications

References 210 publications

Bio‐inspired nanomedicine strategies for artificial blood components

Bio‐inspired nanomedicine strategies for artificial blood components

Preparation of a dual cored hepatoma-specific star glycopolymer nanogel via arm-first ATRP approach

Biomimetic Nanotechnology toward Personalized Vaccines

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