Biomimetic sonodynamic therapy-nanovaccine integration platform potentiates Anti-PD-1 therapy in hypoxic tumors

Zhan, Guiting; Xu, Qingbo; Zhang, Zelong; Wei, Zhaohan; Yong, Tuying; Bie, Nana; Zhang, Xiaoqiong; Li, Xin; Li, Jianye; Gan, Lu; Yang, Xiangliang

doi:10.1016/j.nantod.2021.101195

Cited by 83 publications

(59 citation statements)

References 42 publications

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“…The immunofluorescence staining images revealed that the expression of CD8, IFN-γ, and Granzyme B in tumor tissues of mice after free drug and SPIN D2 injection without US irradiation was similar or slightly higher than those in the control group (Supplementary Figs. 43,44). The treatments of SPINs with US irradiation overall increased the populations of matured DCs in TDLNs, and CTLs in both primary and distant tumors, but reduced the populations of T reg cells (Supplementary Figs.…”

Section: Resultsmentioning

confidence: 97%

“…With deep-tissue penetration and safe nonionizing radiation, US serves as an ideal external stimulus to precisely activate cancer immunotherapy in situ in living subjects. Although sonodynamic process has been combined with chemotherapy, chemodynamic, or phototherapy to treat cancer in preclinical settings, it has been rarely exploited for immunotherapy with only several examples wherein nanosonosensitizers and immune checkpoint inhibitors were independently administrated into mice (Supplementary Table 1 ) 42 , 43 . To acquire the specificity of US-induced immune activation, we have synthesized semiconducting polymer immunomodulatory nanoparticles (SPINs) that underwent sonodynamic process to generate 1 O 2 to specifically cleave the 1 O 2 -sensitive linkers and release the covalently linked immunomodulators.…”

Section: Discussionmentioning

confidence: 99%

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Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Luo

Zeng

et al. 2022

Nat Commun

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Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to be fully unlocked. This study develops deep-tissue activatable cancer sono-immunotherapy based on the discovery of a semiconducting polymer that generates sonodynamic singlet oxygen (1O2) substantially higher than other sonosensitizers. Conjugation of two immunomodulators via 1O2-cleavable linkers onto this polymer affords semiconducting polymer immunomodulatory nanoparticles (SPINs) whose immunotherapeutic actions are largely inhibited. Under ultrasound irradiation, SPINs generate 1O2 not only to directly debulk tumors and reprogram tumor microenvironment to enhance tumor immunogenicity, but also to remotely release the immunomodulators specifically at tumor site. Such a precision sono-immunotherapy eliminates tumors and prevents relapse in pancreatic mouse tumor model. SPINs show effective antitumor efficacy even in a rabbit tumor model. Moreover, the sonodynamic activation of SPINs confines immunotherapeutic action primarily to tumors, reducing the sign of immune-related adverse events.

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Section: Resultsmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Luo

Zeng

et al. 2022

Nat Commun

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“…As a typical instance, Yang et al engineered the SDT‐nanovaccine integration platform through the integration of Mn porphyrin‐based MOF (Mn‐MOF), immune adjuvant and melanoma B16 cell membrane. [ 201 ] Mn‐MOF not only acted as a sonosensitizer but also completed the conversion process of hydrogen peroxide to oxygen. Cell membrane coating bestowed Mn‐MOF with prolonged blood circulation and tumor targeting properties, precisely ameliorating tumor hypoxia and enhancing SDT effect.…”

Section: Nanobiomimetic Medicine For Cancer Therapymentioning

confidence: 99%

Nanobiomimetic Medicine

Chang

Dong

Huang

et al. 2022

Adv Funct Materials

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The application of nanotechnology in medicine aims at developing the precise theranostics of diseases by leveraging the extraordinary effects of engineered nanomedicines, materdicine, and biomaterials. However, finely controlling the biological behavior of nanomaterials in the complex living systems remains a great challenge in terms of accuracy and intelligence. Inspired by nature, biomimetics has become an attractive strategy based on the highly ordered natural biological structure for the development of clinically valuable materials and technologies, arising from the superior bioavailability. The rapid development of biomimetics in nanomedical applications prompts the authors to propose the concept of “nanobiomimetic medicine”, which is a considerable subdiscipline in nanomedicine and materdicine that applies the concept and strategies of biomimetics to facilitate and promote the disease theranostics. Herein, the authors aim to furnish a state‐of‐the‐art review on the latest progress in the field of nanobiomimetic medicine. The design strategies, structural features and biological properties of biomimetic materials are initially introduced to reveal the inherent bionic mechanism and the potential structure‐function relationships. Furthermore, advances with respect to the applications of diverse biomimetic materials are comprehensively summarized. Finally, the current challenges and future direction of nanobiomimetic medicine are discussed and prospected in order to stimulate more biomimetic fundamental and technological breakthroughs in nanomedicine.

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“…To achieve the targeting delivery of nanosystems into tumor sites, Yang and coworkers designed a cell membrane-coated biomimetic nanovaccine to combine SDT with multiple immunotherapies (Zhan et al, 2021). The nanovaccine was constructed by integrating manganese porphyrin-based MOF (Mn-MOF) with CpG ODN, followed by surface coating with cell membranes derived from ovalbumin (OVA)-overexpressing melanoma B16 cells.…”

Section: Combinational Therapy Of Sonodynamic Therapy With Multiple Immunotherapiesmentioning

confidence: 99%

Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy

Cheng

Wang

Zhou

et al. 2021

Front. Bioeng. Biotechnol.

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Immunotherapy is a promising therapeutic strategy for cancer, while it has been demonstrated to encounter the issues of low immune responses and underlying immune-related adverse events. The sonodynamic therapy (SDT) that utilizes sonosensitizers to produce reactive oxygen species (ROS) triggered by ultrasound (US) stimulation can be used to ablate tumors, which also leads to the induction of immunogenic cell death (ICD), thus achieving SDT-induced immunotherapy. Further combination of SDT with immunotherapy is able to afford enhanced antitumor immunity for tumor regression. In this mini review, we summarize the recent development of nanosonosensitizers with US-induced ROS generation for cancer SDT immunotherapy. The uses of nanosonosensitizers to achieve SDT-induced immunotherapy, combinational therapy of SDT with immunotherapy, and combinational therapy of SDT with multiple immunotherapies are briefly introduced. Furthermore, the current concerns and perspectives for the development and further clinical applications of these nanosonosensitizers for SDT-combined immunotherapy of cancer are discussed.

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Biomimetic sonodynamic therapy-nanovaccine integration platform potentiates Anti-PD-1 therapy in hypoxic tumors

Cited by 83 publications

References 42 publications

Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Nanobiomimetic Medicine

Nanosonosensitizers With Ultrasound-Induced Reactive Oxygen Species Generation for Cancer Sonodynamic Immunotherapy

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