Biomimetic porous scaffolds for bone tissue engineering

Wu, S. L.; Liu, Xiangmei; Yeung, Kelvin Wai Kwok; Liu, Changsheng; Yang, Xianjin

doi:10.1016/j.mser.2014.04.001

Cited by 947 publications

(523 citation statements)

References 296 publications

Supporting

Mentioning

474

Contrasting

Unclassified

Order By: Relevance

“…The history of tissue repair using biomaterials can be traced back to the Prehistoric Period and, during a long time, happened in a very empirical manner, expecting only they would be inert, non-toxic and well-tolerated 1 . The evolution in the biomaterials' employ involved the search of devices that stimulated the implant's integration with the nearest tissues through cellular activation, proliferation and differentiation in the implant's site, as well as the subsequent formation of the extracellular matrix intimately associated with the implanted material 2 .…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

Nacer¹,

Silva²,

Poppi³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the biocompatibility and osteogenesis of castor oil polymer doped with SiO 2 or BaTiO 3 nanoparticles. METHODS:Twenty four male rats Wistar were submitted to bone defect filled with castor oil polymer. The animals were distributed in RESULTS:The implants were biocompatible and allowed for progressive osteogenesis through osteoconduction in both observation periods. There was significant bone neoformation at 30 and 60 days in both groups within the histomorphometric evaluation, but group 1's osteogenesis was lesser in the 30 and 60-day periods observed when compared to the animals of group 2. The MEV morphometric evaluation evidenced a lesser percentage of osseous tissue filling within the BaTiO2-doped polymer. CONCLUSION:The castor oil polymer doped with SiO2 or BaTiO3 remained biocompatible and allowed for progressive osteogenesis in both observation periods.

show abstract

Section: Introductionmentioning

confidence: 99%

Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

Nacer¹,

Silva²,

Poppi³

et al. 2015

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Moreover, an accumulation of a large amount of hydrogen could delay bone healing, impede osteoblast adhesion, and osteointegration and block the blood supply as well. [70,71] The final product, magnesium hydroxide, is not highly soluble in water and deposits on the substrate. The created layer would act as a barrier for corrosion attack, but Cl -ions (e.g., from body fluids) react with Mg(OH) 2 .…”

Section: Corrosionmentioning

confidence: 99%

“…[71,72] In bulk magnesium for biomedical applications, coatings made of MgF 2 , hydroxyapatite and chitosan were used. The surface was also alkaline heat treated and phosphated to form a brushite layer (dicalcium phosphate dihydrate).…”

Section: Corrosionmentioning

confidence: 99%

Current Status and Recent Developments in Porous Magnesium Fabrication

et al. 2017

View full text Add to dashboard Cite

A significant number of studies have been dedicated to the fabrication and properties of metallic foams. The most recent research is focused on metals with low weight and good mechanical properties, such as titanium, aluminum, and magnesium. Whereas the first two are already fairly well studied and already find application in industry, magnesium currently remains at the research stage. The present review covers the studies conducted on fabrication techniques, surface modifications, and properties of porous structures made of magnesium and its alloys.

show abstract

“…Most scaffold materials can be chemically treated or biologically functionalized with peptides to enhance their osteoconductivity, degradability and angiogenic response. As the focus of this review is on the hypoxic response as a potential therapeutic target, we refer the reader for more information on biomaterial characteristics and their functionalization to some recent excellent reviews (Bose et al, 2012;Wu et al, 2014).…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration

Stiers

Gastel

Carmeliet

2016

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

a b s t r a c tBone tissue engineering is a promising therapeutic alternative for bone grafting of large skeletal defects. It generally comprises an ex vivo engineered combination of a carrier structure, stem/progenitor cells and growth factors. However, the success of these regenerative implants largely depends on how well implanted cells will adapt to the hostile and hypoxic host environment they encounter after implantation. In this review, we will discuss how hypoxia signalling may be used to improve bone regeneration in a tissue-engineered construct. First, hypoxia signalling induces angiogenesis which increases the survival of the implanted cells as well as stimulates bone formation. Second, hypoxia signalling has also angiogenesis-independent effects on mesenchymal cells in vitro, offering exciting new possibilities to improve tissue-engineered bone regeneration in vivo. In addition, studies in other fields have shown that benefits of modulating hypoxia signalling include enhanced cell survival, proliferation and differentiation, culminating in a more potent regenerative implant. Finally, the stimulation of endochondral bone formation as a physiological pathway to circumvent the harmful effects of hypoxia will be briefly touched upon. Thus, angiogenic dependent and independent processes may counteract the deleterious hypoxic effects and we will discuss several therapeutic strategies that may be combined to withstand the hypoxia upon implantation and improve bone regeneration.

show abstract

Biomimetic porous scaffolds for bone tissue engineering

Cited by 947 publications

References 296 publications

Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

Biocompatibility and osteogenesis of the castor bean polymer doped with silica (SiO2) or barium titanate (BaTiO3) nanoparticles

Current Status and Recent Developments in Porous Magnesium Fabrication

Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration

Contact Info

Product

Resources

About