Biomimetic polymer-based Ag nanocomposites as a antimicrobial platform

Kung, Mei-Lang; Lin, Pei; Peng, Shi; Wu, Deng Chyang; Wu, Wen; Yeh, Bi-Wen; Tai, Ming Hong; Hung, Hsin-Chia; Hsieh, Shuchen

doi:10.1016/j.apmt.2016.05.003

Cited by 32 publications

(20 citation statements)

References 43 publications

(57 reference statements)

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“…Dopamine was auto-polymerized on the surgical blade using a similar technique reported earlier to modify on mica Figure A3 . In which Ag nanoparticles were deposited on surgical blade coated with PDA following our previously reported conditions with AgNO 3 solution [ 40 ]. We have used XPS and SEM-EDX to characterize Ag in the film coatings as shown below in Figure A4 and Figure A5 .…”

Section: Resultsmentioning

confidence: 99%

Polydopamine Ultrathin Film Growth on Mica via In-Situ Polymerization of Dopamine with Applications for Silver-Based Antimicrobial Coatings

et al. 2021

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The development of polydopamine (PDA) coatings with a nanometer-scale thickness on surfaces is highly desirable for exploiting the novel features arising from the specific structure on the molecular level. Exploring the mechanisms of thin-film growth is helpful for attaining desirable control over the useful properties of materials. We present a systematic study demonstrating the growth of a PDA thin film on the surface of mica in consecutive short deposition time intervals. Film growth at each deposition time was monitored through instrumental techniques such as atomic force microscopy (AFM), water contact angle (WCA) analysis, and X-ray photoelectron spectroscopy (XPS). Film growth was initiated by adsorption of the PDA molecules on mica, with subsequent island-like aggregation, and finally, a complete molecular level PDA film was formed on the surface due to further molecular adsorption. A duration of 60−300 s was sufficient for complete formation of the PDA layer within the thickness range of 0.5−1.1 nm. An outstanding feature of PDA ultrathin films is their ability to act as a molecular adhesive, providing a foundation for constructing functional surfaces. We also explored antimicrobial applications by incorporating Ag nanoparticles into a PDA film. The Ag NPs/PDA film was formed on a surgical blade and then characterized and confirmed by SEM-EDS and XPS. The modified film inhibited bacterial growth by up to 42% on the blade after cutting through a pork meat sample.

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Section: Resultsmentioning

confidence: 99%

Polydopamine Ultrathin Film Growth on Mica via In-Situ Polymerization of Dopamine with Applications for Silver-Based Antimicrobial Coatings

et al. 2021

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“…The first is the direct contact of AgNPs with the cell membrane of attached bacterial leading to pits formation which in turn lead to permeability loss and cell death [40]. The other possibility is the release of silver ions from AgNPs which interact with the thiol groups in protein leading to protein deactivation and death of both attached and swimming bacteria [25]. To evaluate the influence of the released silver ions from the coated catheter on the swimming bacteria, the O.D.…”

Section: Resultsmentioning

confidence: 99%

“…It is well reported that the dissolution of AgNPs due to oxidation process results in release of Ag+ ions in the surrounding environment of the bacteria [24]. These ions interact and accumulate on the cell membrane of the bacteria leading to rupture of cell membrane and subsequently leakage of the cytosolic components [25]. In Figure 9A and B, it is clearly shown that the morphology of rounded S. aureus is severely deformed (indicated by white arrows) due to the formation of longitudinal clefts and pits which lead to leakage of cytoplasm and eventually shrinkage of bacteria.…”

Section: Resultsmentioning

confidence: 99%

“…Such surfaces have been decorated with AgNPs using different methods such as chemical deposition, photo–chemical deposition, physical vapor deposition and sputtering deposition techniques [21]. However, in situ formation of AgNPs is a simple and versatile strategy that is wildly used to overcome the complicated multi–steps procedures that limited many applications [24, 25, 26].…”

Section: Introductionmentioning

confidence: 99%

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Facile coating of urinary catheter with bio–inspired antibacterial coating

Yassin

Elkhooly

Elsherbiny

et al. 2019

Heliyon

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A B S T R A C TFormation of bacterial biofilm on indwelling urinary catheters usually causes catheter-associated urinary tract infections (CAUTIs) that represent high percent of nosocomial infections worldwide. Therefore, coating urinary catheter with antibacterial and antifouling coating using facile technique is in great demand. In this study, commercial urinary catheter was coated with a layer of the self-polymerized polydopamine which acts as active platform for the in situ formation of silver nanoparticle (AgNPs) on catheter surface. The formed coating was intensively characterized using spectroscopic and microscopic techniques. The coated catheter has the potential to release silver ion in a sustained manner with a concentration of about 2-4 μg ml À1 . Disk diffusion test and colony forming unites assay verified the significant bactericidal potential of the AgNPs coated catheter against both gram-positive and gram-negative bacteria as a consequence of silver ion release. In contrast to commercial catheter, the AgNPs coated catheter prevented the adherence of bacterial cells and biofilm formation on their surfaces. Interestingly, scanning electron microscope investigations showed that AgNPs coated catheter possess greater antifouling potential against gram-positive bacteria than against gram-negative bacteria. Overall, the remarkable antibacterial and antifouling potential of the coated catheter supported the use of such facile approach for coating of different medical devices for the prevention of nosocomial infections.

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“…Additionally, the presence of silver ions in solution (Ag+) can modify osmotic pressure, inducing the release of intracellular material, which can lead to subsequent cell membrane collapse. Hsieh and colleagues [ 65 ] measured, as a function of time, the release in the solution of silver ions from dopamine/Ag modified surfaces, and although the concentrations are very small (~2755.5 ± 3.8 µg L −1 ) of Ag + after 3 h, it is probably enough, at least locally, to change the osmotic pressure to finally prevent bacterial adhesion. Results of that work revealed that silver action is effective against bacteria and safe with endothelial cells, showing their potential use in catheters.…”

Section: Polymeric Materials With Antibacterial Activitymentioning

confidence: 99%

Polymeric Materials with Antibacterial Activity: A Review

Olmos

González‐Benito

2021

Polymers

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Infections caused by bacteria are one of the main causes of mortality in hospitals all over the world. Bacteria can grow on many different surfaces and when this occurs, and bacteria colonize a surface, biofilms are formed. In this context, one of the main concerns is biofilm formation on medical devices such as urinary catheters, cardiac valves, pacemakers or prothesis. The development of bacteria also occurs on materials used for food packaging, wearable electronics or the textile industry. In all these applications polymeric materials are usually present. Research and development of polymer-based antibacterial materials is crucial to avoid the proliferation of bacteria. In this paper, we present a review about polymeric materials with antibacterial materials. The main strategies to produce materials with antibacterial properties are presented, for instance, the incorporation of inorganic particles, micro or nanostructuration of the surfaces and antifouling strategies are considered. The antibacterial mechanism exerted in each case is discussed. Methods of materials preparation are examined, presenting the main advantages or disadvantages of each one based on their potential uses. Finally, a review of the main characterization techniques and methods used to study polymer based antibacterial materials is carried out, including the use of single force cell spectroscopy, contact angle measurements and surface roughness to evaluate the role of the physicochemical properties and the micro or nanostructure in antibacterial behavior of the materials.

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Biomimetic polymer-based Ag nanocomposites as a antimicrobial platform

Cited by 32 publications

References 43 publications

Polydopamine Ultrathin Film Growth on Mica via In-Situ Polymerization of Dopamine with Applications for Silver-Based Antimicrobial Coatings

Polydopamine Ultrathin Film Growth on Mica via In-Situ Polymerization of Dopamine with Applications for Silver-Based Antimicrobial Coatings

Facile coating of urinary catheter with bio–inspired antibacterial coating

Polymeric Materials with Antibacterial Activity: A Review

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