Biomimetic nanoreactor for targeted cancer starvation therapy and cascade amplificated chemotherapy

Shao, Fengying; Wu, Yafeng; Tian, Zhaoyan; Liu, Songqin

doi:10.1016/j.biomaterials.2021.120869

Cited by 75 publications

(54 citation statements)

References 45 publications

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“…Bio-inspired or biomimetic design of biomaterials presents new possibilities for developing implantable devices with enhanced biocompatibility and novel functions [1][2][3][4][5][6][7][8]. No study has yet reported a potential application of biomimetic surface morphology, particularly at the nano-level, to endosseous implants for commercial use in the fields of dental and orthopedic surgery [9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Zirconia with Cactus-Inspired Meso-Scale Spikes and Nano-Trabeculae for Enhanced Bone Integration

Saruta

Ozawa

Okubo

et al. 2021

IJMS

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Biomimetic design provides novel opportunities for enhancing and functionalizing biomaterials. Here we created a zirconia surface with cactus-inspired meso-scale spikes and bone-inspired nano-scale trabecular architecture and examined its biological activity in bone generation and integration. Crisscrossing laser etching successfully engraved 60 μm wide, cactus-inspired spikes on yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) with 200–300 nm trabecular bone-inspired interwoven structures on the entire surface. The height of the spikes was varied from 20 to 80 μm for optimization. Average roughness (Sa) increased from 0.10 μm (polished smooth surface) to 18.14 μm (80 μm-high spikes), while the surface area increased by up to 4.43 times. The measured dimensions of the spikes almost perfectly correlated with their estimated dimensions (R2 = 0.998). The dimensional error of forming the architecture was 1% as a coefficient of variation. Bone marrow-derived osteoblasts were cultured on a polished surface and on meso- and nano-scale hybrid textured surfaces with different spike heights. The osteoblastic differentiation was significantly promoted on the hybrid-textured surfaces compared with the polished surface, and among them the hybrid-textured surface with 40 μm-high spikes showed unparalleled performance. In vivo bone-implant integration also peaked when the hybrid-textured surface had 40 μm-high spikes. The relationships between the spike height and measures of osteoblast differentiation and the strength of bone and implant integration were non-linear. The controllable creation of meso- and nano-scale hybrid biomimetic surfaces established in this study may provide a novel technological platform and design strategy for future development of biomaterial surfaces to improve bone integration and regeneration.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Zirconia with Cactus-Inspired Meso-Scale Spikes and Nano-Trabeculae for Enhanced Bone Integration

Saruta

Ozawa

Okubo

et al. 2021

IJMS

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“…8 d, e). In the latest research, Shao et al reported a biomimetic nanoreactor (AQ4N/GOx@ZIF-8@CM) based on GOx and banoxantrone (AQ4N) encapsulated metal–organic framework ZIF-8 which was further modified by the cancer cell membrane (CM) for starvation therapy synergized and cascade amplified hypoxia-activated chemotherapy [ 52 ]. The encapsulated Gox and AQ4N in ZIF-8 will not release until they reach the tumor site, for ensuring the tumor-specific synergistic starving/chemotherapy within tumoral mildly acidic microenvironment (Fig.…”

Section: Nanomedicine-instructed Chemotherapy Synergistic Cancer Therapymentioning

confidence: 99%

Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

Shi

2022

J Nanobiotechnol

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Chemotherapy remains one of the most prevailing regimens hitherto in the fight against cancer, but its development has been being suffering from various fatal side effects associated with the non-specific toxicity of common chemical drugs. Advances in biomedical application of nanomedicine have been providing alternative but promising approaches for cancer therapy, by leveraging its excellent intrinsic physicochemical properties to address these critical concerns. In particular, nanomedicine-enabled chemotherapy has been established as a safer and promising therapeutic modality, especially the recently proposed nanocatalytic medicine featuring the capabilities to generate toxic substances by initiating diverse catalytic reactions within the tumor without directly relying on highly toxic but non-selective chemotherapeutic agents. Of special note, under exogenous/endogenous stimulations, nanomedicine can serve as a versatile platform that allows additional therapeutic modalities (photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), etc.) to be seamlessly integrated with chemotherapy for efficacious synergistic treatments of tumors. Here, we comprehensively review and summarize the representative studies of multimodal synergistic cancer treatments derived from nanomedicine and nanocatalytic medicine-enabled chemotherapy in recent years, and their underlying mechanisms are also presented in detail. A number of existing challenges and further perspectives for nanomedicine-synergized chemotherapy for malignant solid tumor treatments are also highlighted for understanding this booming research area as comprehensively as possible. Graphical Abstract

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“…Cancer can be "starved" by inhibiting the uptake of glucose [74]. Since glucose oxidase (GOx) can convert glucose and oxygen into gluconic acid and H 2 O 2 , GOx-mediated starvation can be combined with other treatment methods to treat cancer synergistically [75]. For example, load GOx and Ce6 into PLGA/metal-organic framework (MOF) core-shell nano-components and deposit hyaluronic acid (HA) on the surface to stabilize MnO 2 to build the target nano-platform [76].…”

Section: Synergistic Therapymentioning

confidence: 99%

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

Li¹,

Qiu²

2021

Oncologie

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Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies can selectively kill local tumors without endangering normal tissues. At present, there are more and more researches on optimizing the pharmacological properties of Ce6-based therapeutic agents. Therefore, this review focuses on the properties of Ce6 and the research progress of various nano-scale delivery strategies based on Ce6 in tumor treatment. At last, we summarized the positive impact and bright prospects of Ce6-based nanomaterials in cancer treatment applications.

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Biomimetic nanoreactor for targeted cancer starvation therapy and cascade amplificated chemotherapy

Cited by 75 publications

References 45 publications

Biomimetic Zirconia with Cactus-Inspired Meso-Scale Spikes and Nano-Trabeculae for Enhanced Bone Integration

Biomimetic Zirconia with Cactus-Inspired Meso-Scale Spikes and Nano-Trabeculae for Enhanced Bone Integration

Nanomedicine-enabled chemotherapy-based synergetic cancer treatments

The Current Status of Chlorin e6-Based Nanoscale Delivery Systems for Cancer Therapy

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