Biomimetic nanomaterials: Development of protein coated nanoceria as a potential antioxidative nano-agent for the effective scavenging of reactive oxygen species in vitro and in zebrafish model

Bhushan, Bharat; Soundharapandiyan, Nandhagopal; Kannan, Rajaretinam Rajesh; Gopinath, P.

doi:10.1016/j.colsurfb.2016.06.035

Cited by 15 publications

(8 citation statements)

References 64 publications

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“…95 Antioxidant properties of protein-coated CeO 2 NPs were also demonstrated in zebrafish embryos, which prevented H 2 O 2 -induced oxidative stress, malformations, and death by abatement of intracellular ROS. 96 CeO 2 NPs were found to be non-toxic to zebrafish embryos in several studies, [41][42][43] which was confirmed by the results of this study. However, the influence of shape on CeO 2 NP toxicity has also been investigated, suggesting that, in contrast to the spherical CeO 2 NPs used in most studies, rod-like CeO 2 NPs trigger toxicity in the gut.…”

Section: Low Toxicity Mnmssupporting

confidence: 87%

Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos

Hansjosten

Takamiya

Rapp

et al. 2022

Environ. Sci.: Nano

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Section: Low Toxicity Mnmssupporting

confidence: 87%

Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos

Hansjosten

Takamiya

Rapp

et al. 2022

Environ. Sci.: Nano

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“…The zebrafish has a relatively simple nervous system, which allows imaging of neurons easily. This creates the possibility to visualise specific neuronal proteins of interest and thus provide a wonderful opportunity to study the neurological processes in detail 49 , 126 – 130 . Zebrafish larvae are small transparent vertebrates, which are highly suitable to confocal microscopy when labelled with dyes 131 .…”

Section: Real-time Neurological Imaging Studies In Zebrafishmentioning

confidence: 99%

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

2018

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Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational research on human neurological disorders. In this review, we appraise the high degree of neurological and behavioural resemblance of zebrafish with humans. It is highly validated as a powerful vertebrate model for investigating human neurodegenerative diseases. The neuroanatomic and neurochemical pathways of zebrafish brain exhibit a profound resemblance with the human brain. Physiological, emotional and social behavioural pattern similarities between them have also been well established. Interestingly, zebrafish models have been used successfully to simulate the pathology of Alzheimer’s disease (AD) as well as Tauopathy. Their relatively simple nervous system and the optical transparency of the embryos permit real-time neurological imaging. Here, we further elaborate on the use of recent real-time imaging techniques to obtain vital insights into the neurodegeneration that occurs in AD. Zebrafish is adeptly suitable for Ca2+ imaging, which provides a better understanding of neuronal activity and axonal dystrophy in a non-invasive manner. Three-dimensional imaging in zebrafish is a rapidly evolving technique, which allows the visualisation of the whole organism for an elaborate in vivo functional and neurophysiological analysis in disease condition. Suitability to high-throughput screening and similarity with humans makes zebrafish an excellent model for screening neurospecific compounds. Thus, the zebrafish model can be pivotal in bridging the gap from the bench to the bedside. This fish is becoming an increasingly successful model to understand AD with further scope for investigation in neurodevelopment and neurodegeneration, which promises exciting research opportunities in the future.

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“…(2015) reported, we had a significant reduction in the weight and yield of tomato fruits under moderate salinity level concerning the control treatment in most of the genotypes used. Many plant species show an increase in proline content as a direct response to salt stress, which contributes to the protein molecules and membrane stabilization associated with ROS elimination in the cell (Bhushan et al., 2016). The damages are directly linked to the period of exposure, the concentration of salt, the water potential of the cultivar, and the volume of water transpired by the plant (Negrão et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Can saline irrigation improve the quality of tomato fruits?

et al. 2022

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This study aimed to investigate the effect of irrigation with saline water on fruit quality, yield, and plant nutrition of tomato (Lycopersicon esculentum Mill.) cultivars. Tomato cultivation was carried out under protected environment conditions in a double row system with drip irrigation performed according to the demand of the plants. Commercial fruit weight, commercial fruit number, fruit yield, absorption of Ca, N, P, S, K, and Mg were all affected by saline irrigation. The leaf Na concentration and the concentration of total phenolic compounds, total titratable acids, total soluble solids, vitamin C, carotenoids, and flavonoids in the fruits were favored from the increase in irrigation salinity. The Na+ causes a deficiency of Ca, which impairs seed formation in tomato fruits, as Ca is a structural element in the formation of the pollen grain. The Onix genotype had the highest yield, weight, and number of commercial fruits under control and moderate salt stress conditions. Saline water impaired nutrient absorption and improved tomato fruit quality. Under salt stress, tomato plants were able to absorb and translocate large amounts of Na+ to the shoot and even improved the organoleptic quality of fruits, increasing the content of carotenoids, flavonoids, vitamin C, total phenolic compounds, total soluble solids, and total titratable acids of tomato fruits. The clustering analysis was able to show the highest genetic dissimilarity between the group composed of Shanty, Maestrina, and Ipa 6 and the group with Sheena, Totalle, and Pizzadoro under salt stress conditions; also, it evidenced the greater stability of these genotypes.

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Biomimetic nanomaterials: Development of protein coated nanoceria as a potential antioxidative nano-agent for the effective scavenging of reactive oxygen species in vitro and in zebrafish model

Cited by 15 publications

References 64 publications

Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos

Surface functionalisation-dependent adverse effects of metal nanoparticles and nanoplastics in zebrafish embryos

Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery

Can saline irrigation improve the quality of tomato fruits?

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