Biomimetic Nanoemulsions for Oxygen Delivery In Vivo

Zhuang, Jia; Ying, Man; Spiekermann, Kevin; Holay, Maya; Zhang, Yue; Chen, Fang; Gong, Hua; Lee, Joo Hee; Gao, Weiwei; Fang, Ronnie H.; Zhang, Liangfang

doi:10.1002/adma.201804693

Cited by 91 publications

(88 citation statements)

References 44 publications

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“…With increasing reports on the potential of biomimetic drug carriers, more recent research has been focused on their functionality . Another attractive aspect of the use of cell membranes as surface coatings is the fact that they can effectively inherit proteins or other biologically active molecules from their source and “mimic” the source cells' characteristic activities in vivo . This advantage has already been explored for camouflages derived from a wide range of cells, including platelets, leukocytes, macrophages, stem cells, and cancer cells .…”

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confidence: 99%

Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

et al. 2019

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Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, and so represents a promising solution for the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage to endow it with optimized or additional properties, in particular properties critical to a “smart” drug delivery system, such as stimuli‐responsive drug release. A pH‐responsive biomimetic “platesome” for specific drug delivery to tumors and tumor‐triggered drug release is described. This platesome nanovehicle is constructed by merging platelet membranes with functionalized synthetic liposomes and exhibits enhanced tumor affinity, due to its platelet membrane–based camouflage, and selectively releases its cargo in response to the acidic microenvironment of lysosomal compartments. In mouse cancer models, it shows significantly better antitumor efficacy than nanoformulations based on a platesome without pH responsiveness or those based on traditional pH‐sensitive liposomes. A convenient way to incorporate stimuli‐responsive features into biomimetic nanoparticles is described, demonstrating the potential of engineered cell membranes as biomimetic camouflages for a new generation of biocompatible and efficient nanocarriers.

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confidence: 99%

Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

et al. 2019

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“…Cell membrane–coated nanoparticles, with their unique properties, have recently been leveraged in the design of anticancer vaccines . RBC‐NPs are known for their reduced host immune interactions and have been used extensively as a delivery vehicle . Along these lines, RBC‐NPs were used as a carrier for glycoprotein 100 (gp100), a tumor‐associated antigen enriched in B16F10 melanoma .…”

Section: Biomimetic Anticancer Nanovaccinesmentioning

confidence: 99%

Biomimetic Nanotechnology toward Personalized Vaccines

et al. 2019

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While traditional approaches for disease management in the era of modern medicine have saved countless lives and enhanced patient well‐being, it is clear that there is significant room to improve upon the current status quo. For infectious diseases, the steady rise of antibiotic resistance has resulted in super pathogens that do not respond to most approved drugs. In the field of cancer treatment, the idea of a cure‐all silver bullet has long been abandoned. As a result of the challenges facing current treatment and prevention paradigms in the clinic, there is an increasing push for personalized therapeutics, where plans for medical care are established on a patient‐by‐patient basis. Along these lines, vaccines, both against bacteria and tumors, are a clinical modality that could benefit significantly from personalization. Effective vaccination strategies could help to address many challenging disease conditions, but current vaccines are limited by factors such as a lack of potency and antigenic breadth. Recently, researchers have turned toward the use of biomimetic nanotechnology as a means of addressing these hurdles. Recent progress in the development of biomimetic nanovaccines for antibacterial and anticancer applications is discussed, with an emphasis on their potential for personalized medicine.

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“…[43] Zhang's group developed nanoemulsions consisting of perfluorocarbon stabilized by RBC membrane (RBC-PFC) for alternative blood transfusion. [44] The nanoformulation can be stored for a long time and showed improved oxygen-carrying ability. RBC-PFC may have the potential as an alternative to RBCs for transfusion.…”

Section: Circulationmentioning

confidence: 99%

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

Liu

Zou

Qin

et al. 2020

Adv Funct Materials

141

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Surface modification of nanomaterials is essential for their biomedical applications owing to their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell membrane-coating technology has been proposed as an ideal approach to modify nanomaterials owing to its facile functionalized process and good biocompatibility for improving performances of synthetic nanomaterials. Here, recent advances of cell membrane-coated nanomaterials are reviewed based on the main biological functions of the cell membrane in living cells. An overview of the cell membrane is introduced to understand its functions and potential applications. Then, the applications of cell membrane-coated nanomaterials based on the functions of the cell membrane are summarized, including physical barrier with selective permeability and cellular communication via information transmission and reception processes. Finally, perspectives of biomedical applications and challenges about cell membrane-coated nanomaterials are discussed.

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Biomimetic Nanoemulsions for Oxygen Delivery In Vivo

Cited by 91 publications

References 44 publications

Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity

Biomimetic Nanotechnology toward Personalized Vaccines

Recent Advances of Cell Membrane‐Coated Nanomaterials for Biomedical Applications

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