Biomimetic nanocomposite hydrogel networks for robust wet adhesion to tissues

Chen, Yajun; Qin, Hanglan; Mensaha, Alfred; Wang, Qingqing; Huang, Fenglin; Wei, Qufu

doi:10.1016/j.compositesb.2021.109071

Cited by 35 publications

(17 citation statements)

References 69 publications

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“…The decreased adhesive strength compared to the values observed in 10 s and 2 min (16.9 kPa, 18.0 kPa) was caused by the hydrogel's inevitable swelling and loss of TP molecules. 5 However, the adhesion strength was still comparable to that of commercial fibrin sealant. 23 Besides, it was reported that the body fluid had varied pH values (5−8) in different tissues.…”

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 86%

“…45,46 Overall, the hydrogel exhibited relatively stable adhesive strength in PBS with varied pH values, indicating its potential as a visceral wound dressing. Furthermore, different from most single-used underwater adhesive hydrogels, 5,47,48 the hydrogel also exhibited repeatable underwater adhesion (Figure S14). The decreased adhesive strength after adhering-stripping was due to the irreversible covalent bonds between -NHS groups on hydrogel and -NH 2 groups on tissues.…”

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 89%

“…The in vitro drug release behavior of NF-HG was studied according to previous work. 5 The details are available in SI Experimental section.…”

Section: Methodsmentioning

confidence: 99%

“…4 Although there were some reported underwater tissue-adhesive hydrogels, most of them showed adhesiveness to both biotic and abiotic materials. 2,5,6 This nonspecific underwater adhesiveness will make manipulating hydrogels with medical devices more difficult without interfering with wound closure. The third one resides in the slow adhesion formation, as most tissue adhesives require some time (longer than 1 min) to diffuse their molecules through the interfacial water to form adhesion to tissues.…”

Section: Introductionmentioning

confidence: 99%

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Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Chen

Guo

Mensah

et al. 2021

ACS Appl. Mater. Interfaces

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Underwater adhesives with efficient, selective, and repeatable adhesion are urgently needed for biomedical applications. Catechol-containing hydrogel adhesives have aroused much interest, but the design of specific underwater adhesives to biotic surfaces is still a challenge. Here we report a facile way that recapitulates the adhesion mechanism of mussel and sea gooseberry for the development of robust and specific hydrogel adhesives. With an exquisite design of chemical bonding, catechol chemistry, and electrostatic interaction, the hydrogel consisting of poly(acrylic acid) grafted with N-hydroxysuccinimide ester (PAA-NHS ester), tea polyphenol (TP), chitosan (CS), and Al 3+ exhibited fast, specific, and repeatable underwater adhesion to various biological tissues, such as porcine skin, intestine, liver, and shrimp. Furthermore, nanofibers-hydrogel composite (NF-HG) was prepared via the wicking effect of curcumin-loaded electrospun nanofibers. The NF-HG exhibited pH-responsive color changing properties, sustained drug release, and good cell viability, which made it suitable as a novel wound healing material. This strategy may provide great inspiration for designing multifunctional specific underwater adhesives.

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Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 86%

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 89%

“…The in vitro drug release behavior of NF-HG was studied according to previous work. 5 The details are available in SI Experimental section.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Chen

Guo

Mensah

et al. 2021

ACS Appl. Mater. Interfaces

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“…versatile functional underwater adhesives on tissues. [ 9 ] Mussel‐inspired polydopamine (PDA) composites with intelligent response characteristics and strong antioxidant properties have been well studied in biomedicine. [ 10–12 ] Also learning from the extracellular matrix (ECM), nanofibrillar hydrogels as ECM‐analogs and with favorable fluorescence properties has been developed.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Bioinspired Hydrogels with Environment‐Responsive Characteristics for Biomedical Applications

Ran

Wang

et al. 2022

Macromolecular Bioscience

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The development of hydrogel‐integrated soft materials via the incorporation of therapeutic medicines into biocompatible hydrogels, serving as host, will significantly contribute to advances in medical diagnosis and treatment. Furthermore, intelligent hydrogels having the ability to respond to local environmental conditions offer a promising approach for the development of novel solutions in the biomedical field. Bioinspired intelligent hydrogels are now becoming a potentially powerful biomaterial class for tissue engineering, drug delivery, and medical device. Recent advances include bioinspired intelligent hydrogels that possess unique mechanical and optical properties as a result of their nature‐inspired complex‐structured design. This review highlights the latest advances in intelligent bionic hydrogels, as well as strategies targeting smart response of their characteristics across multiple dimensions (such as temperature, light, pH, among others). Finally, the potential development and prospective application of mimicking the natural intelligence of multifunctional medical hydrogels are also discussed.

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Adhesive Hydrogels

Bhattacharya,

Neogi

2023

Adhesives in Biomedical Applications

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Biomimetic nanocomposite hydrogel networks for robust wet adhesion to tissues

Cited by 35 publications

References 69 publications

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Recent Advances in Bioinspired Hydrogels with Environment‐Responsive Characteristics for Biomedical Applications

Adhesive Hydrogels

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