Biomimetic nano-c-HAp hybrid layer engineering and determination of mechanisms of its integration with native hard dental tissue

Development of a Hybrid Biomimetic Enamel-Biocomposite Interface and a Study of Its Molecular Features Using Synchrotron Submicron ATR-FTIR Microspectroscopy and Multivariate Analysis Techniques

“…In our case, the overlap of the bands in FTIR spectra can be observed in the 1100–960 cm −1 region, where several vibrations associated with the phosphate groups of the PO 4 3− mineral component of enamel as well as the Si-O vibrations of silicon dioxide included in the dental material [ 83 , 84 ], or in the 1700–1200 cm −1 range, which is the fingerprint for the organic structure. However, these inconveniences can be overcome by using multidimensional methods for analyzing a large set of spectroscopic data, allowing for the efficient processing and systematization of an array of spectra of multicomponent materials collected as 2D FTIR maps [ 87 , 88 , 89 ], and detecting and confirming the relationships and similarities between FTIR spectra in the set. Such methods include hierarchical cluster analysis (HCA) and the principal components method (PCA).…”

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

“…Molecular analysis using FTIR and attenuated total reflection (ATR)-FTIR is suitable for studying the interface of different materials, as well as to evaluate their interactions. This approach was utilised to study biomimetic composites, dental materials, dentine and enamel interface, and phosphate and amide groups (corresponding to mineral and organic components respectively [ 324 , 325 , 326 , 337 , 347 , 352 , 562 ], Figure 9 m), to develop hybrid interfaces. In another study, the distribution of organic and carbonate contents was determined from ancient and modern teeth [ 341 ].…”

“…The data were extracted from Endnote software in ‘.txt’ format and manually edited to arrange the studies by techniques. In total, 31 terms were considered based on these studies [ 11 , 31 , 39 , 56 , 57 , 77 , 78 , 89 , 90 , 121 , 169 , 170 , 171 , 172 , 173 , 175 , 193 , 195 , 247 , 266 , 286 , 294 , 299 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , ...…”

“…The data were extracted from Endnote software (Clarivate) in ‘.txt’ format and manually edited to match the reading format and correlation of words; for example, British spelling was applied when translating non-English titles and acronyms were generally written in full length. The minimum number of occurrences of a term was set to four, and in total 140 terms were used based on these studies [ 11 , 31 , 39 , 56 , 57 , 77 , 78 , 89 , 90 , 121 , 169 , 170 , 171 , 172 , 173 , 175 , 193 , 195 , 247 , 266 , 286 , 294 , 299 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 ,…”

Engineering of biomimetic mineralized layer formed on the surface of natural dental enamel

“…The reproduction and successful restoration of dental tissue can be effectively achieved with the use of nanocrystalline carbonate-substituted hydroxyapatite HAp (Са 10 (PO 4 ) 6-x (CO 3 ) x (OH) 2-x , 0.1 < x < 0.3) due to its maximum correspondence to the apatite of the dental matrix [10][11][12][13][14][15]. As it has already been shown in several works [13,[16][17][18][19] related to the problem of dental tissue restoration, in order to achieve the necessary crystal density, chemical resistance, and mechanical strength and hardness of the mineralized layers requires the joint usage of HAp and polar amino acids for the formation of a biomimetic mineralized layer, as well as the pre-determined conditions for the interaction and conjugation of ncHAp crystals with an organic enamel matrix [20][21][22][23].…”