Biomimetic mineralized amorphous carbonated calcium phosphate-polycaprolactone bioadhesive composites as potential coatings on implant materials

Furkó, Mónika; Detsch, Rainer; Tolnai, Istvan; Balázsi, Katalin; Boccaccını, Aldo R.; Balázsi, Csaba

doi:10.1016/j.ceramint.2023.02.231

Cited by 5 publications

(4 citation statements)

References 70 publications

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“…The physical interactions between poly(α-hydroxyester) and CaPO 4 are shown in Figure 2 [337]. Another good illustration is available in the literature [51]. Reprinted from Ref.…”

Section: Apatite-based Formulationsmentioning

confidence: 98%

“…In line with previous research, we also explore the following: "for the purpose of this review, composites are defined as those having a distinct phase distributed through their bulk, as opposed to modular or coated components" ( [40], p. 1329). Therefore, with a few exceptions, we did not consider CaPO 4 deposits produced on different materials by various deposition techniques [41][42][43][44][45][46] or CaPO 4 coated with other compounds [47][48][49][50][51]. However, we did include composite coatings.…”

Section: General Knowledge and Experiencementioning

confidence: 99%

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Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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“…The physical interactions between poly(α-hydroxyester) and CaPO 4 are shown in Figure 2 [337]. Another good illustration is available in the literature [51]. Reprinted from Ref.…”

Section: Apatite-based Formulationsmentioning

confidence: 98%

Section: General Knowledge and Experiencementioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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“…All the performed biocompatibility tests, cell culture procedures and standard protocols can be found in a more detailed description and an extended form in our previous study [41]…”

Section: Biocompatibility Characterizations Of the Prepared Samples A...mentioning

confidence: 99%

Amorphous, Carbonated Calcium Phosphate and Biopolymer-Composite-Coated Si3N4/MWCNTs as Potential Novel Implant Materials

Furko,

Detsch,

Horváth

et al. 2024

Nanomaterials

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A biodegradable amorphous carbonated calcium phosphate (caCP)-incorporated polycaprolactone (PCL) composite layer was successfully deposited by a spin coater. In this specific coating, the PCL acts as a bioadhesive, since it provides a better adherence of the coatings to the substrate compared to powder coatings. The caCP–PCL coatings were deposited and formed thin layers on the surface of a Si3N4–3 wt% MWCNT (multiwalled carbon nanotube) substrate, which is an emerging type of implant material in the biomedical field. The composite coatings were examined regarding their morphology, structure and biological performance. The biocompatibility of the samples was tested in vitro with MC3T3-E1 preosteoblast cells. Owing to the caCP–PCL thin layer, the cell viability values were considerably increased compared to the substrate material. The ALP and LDH tests showed numerous living cells on the investrigated coatings. The morphology of the MC3T3-E1 cells was examined by fluorescent staining (calcein and DAPI) and scanning electron microscopy, both of which revealed a well-spread, adhered and confluent monolayer of cells. All performed biocompatibility tests were positive and indicated the applicability of the deposited thin composite layers as possible candidates for orthopaedic implants for an extended period.

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“…It is biocompatible, biodegradable formed by hexanoate repeating units and exhibits excellent flexibility [ [1] , [2] , [3] , [4] , [5] ]. PCL is used in tissue regeneration [ 6 ], controlled drug delivery [ 7 ], implants and food packaging [ 8 ], wound dressing [ 9 ], among other applications. PCL may not have satisfactory properties for certain applications, such as hydrophilicity for tissue engineering applications, tensile properties in implants, and osteoconductivity [ [10] , [11] , [12] ].…”

Section: Introductionmentioning

confidence: 99%

Gamma radiation effect on the chemical, mechanical and thermal properties of PCL/MCM-48-PVA nanocomposite films

Paula

Azevedo

Silva

et al. 2023

Heliyon

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Biomimetic mineralized amorphous carbonated calcium phosphate-polycaprolactone bioadhesive composites as potential coatings on implant materials

Cited by 5 publications

References 70 publications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Amorphous, Carbonated Calcium Phosphate and Biopolymer-Composite-Coated Si3N4/MWCNTs as Potential Novel Implant Materials

Gamma radiation effect on the chemical, mechanical and thermal properties of PCL/MCM-48-PVA nanocomposite films

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