Biomimetic mineralization of the carbonates regulated by using hydroxypropyl methylcellulose macromolecules as organic templates

Yang, Tianli; He, Ren; Omeoga, Uche; Wang, Lin; Sun, Renrui; Zhang, Ning; Wang, Wenlei; Xu, Dong; Zeng, Dewen

doi:10.1016/j.jcrysgro.2018.12.029

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…They can provide a certain microenvironment for delivering amorphous precursors and controlling the diffusion of ions in gels [31,37]. The polyhydroxy groups in the hydrophobic microregions can restrain ions and influence the diffusion speed of loaded particles [38]. In this study, when HPMC was in contact with artificial saliva, the PAsp-stabilized ACP nanoparticles diffused into the HPMC gel scaffold (Fig.…”

Section: Discussion On the Biomimetic Mineralization Of Dentinmentioning

confidence: 71%

A Novel Mineralizing film Induces Biomimetic Mineralization

Wang

Zhou

Fan

et al. 2021

Preprint

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Demineralization of tooth hard tissues leads to dental caries, which causes health problem and economic burden throughout the world. Biomimetic mineralization strategy is expected to reverse initial dental caries. Commercially available mineralizing anti-carious products lead to indefinite clinical results because they could not continuously replenish calcium and phosphate resources. Herein, we prepared a novel mineralizing film (NMF) consisting of hydroxypropylmethylcellulose (HPMC) and polyaspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles. HPMC containing multiple hydroxyls is a gel-forming material that could be either desiccated to be a dry film or gradually changed into gel in moist milieu. The HPMC was, for the first time, used as a carrier of PAsp-ACP nanoparticles for delivering biomimetic mineralization in moist milieu. Our results indicated the hydroxyls and methoxyls of HPMC could assist the stability of PAsp-ACP nanoparticles and maintain their bioactivity of mineralization. The results further demonstrated that the NMF bioinspired the early mineralization of demineralized dentin at 24 hrs and the heavy mineralization of the whole demineralized dentin (3-4 µm) at 72-96 hrs without any cytotoxicity and mucosa irritation. Therefore, the NMF might be promising mineralizing strategy for preventive dentistry with efficient mineralization capability.

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Section: Discussion On the Biomimetic Mineralization Of Dentinmentioning

confidence: 71%

A Novel Mineralizing film Induces Biomimetic Mineralization

Wang

Zhou

Fan

et al. 2021

Preprint

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“…HPMC contains hydrophobic microregions associated with its hydrophobic methoxy groups that provides a porous microstructure for drug loading and releasing. 62 Moreover, the polyhydroxy groups of HPMC in the hydrophobic microregions can restrain ions. 62 Thus, the abundance of Ca, P, and F ions released from the mineralizing film might be held up in the three-dimensional hydrogel network for a certain time, which provides a micro-environment for biomineralization.…”

Section: Discussionmentioning

confidence: 99%

“…62 Moreover, the polyhydroxy groups of HPMC in the hydrophobic microregions can restrain ions. 62 Thus, the abundance of Ca, P, and F ions released from the mineralizing film might be held up in the three-dimensional hydrogel network for a certain time, which provides a micro-environment for biomineralization. 63,64 And in parallel, the phase stability of AFCP has been enhanced to 8~12 h by the HPMC (Figure 4A).…”

Section: Discussionmentioning

confidence: 99%

A Hydroxypropyl Methylcellulose Film Loaded with AFCP Nanoparticles for Inhibiting Formation of Enamel White Spot Lesions

Zhang¹,

Shi²,

Zheng³

et al. 2021

IJN

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“…Hydroxypropyl methylcellulose (HPMC) is abundant, cheap, and biocompatible [23]. A gel can be formed by heating the solution.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hydroxypropyl Methylcellulose (HPMC) on the Reinforcement of Sand by Microbial-Induced Calcium Carbonate Precipitation (MICP)

Zhu

Yuan

et al. 2022

Applied Sciences

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Microbial-induced calcium carbonate precipitation (MICP) is a new technology used for reinforcing soils through microbial mineralization. However, the existing MICP treatment technology is more suiTable for deeper soils due to its high permeability. In this study, HPMC, a cohesive material combined with Sporosarcina pasteurii-induced calcium carbonate precipitation was used to improve the surface layer of the soil. It was also tested in different contents of bacterial solutions and cementation solutions and with a different number of MICP treatments, and was analyzed and discussed by measuring the surface layer strength, calcium carbonate content generated in the crust, rainfall erosion resistance, wind erosion resistance, and ammonia retention rate of the specimens. The microstructure of the samples was investigated by XRD and SEM. It was shown that the addition of HPMC and increasing the number of MICP treatments were effective in the increase in the calcium carbonate content in the surface crust, but had no effect on the total amount of induced calcium carbonate. The combination of HPMC addition and MICP technology can effectively reduce rainwater scour loss and wind erosion loss, and increase its rainfall erosion resistance and wind erosion resistance. Rainfall losses were reduced by up to 30% in specimens treated with HPMC for MICP technology. When the wind speed was 12 m/s, the maximum mass loss rate of the specimens treated with HPMC for MICP was only 0.828%. The addition of HPMC can effectively improve the ammonia absorption rate and reduce the release of ammonia in the process of MICP technology, which is of great significance for environmental protection. The microstructure showed that the addition of HPMC and the increase in the number of treatments using MICP technology can make the surface structure of the specimens more compact, and the calcium carbonate can more effectively fill the pores and cement the soil particles, while the addition of HPMC may not change the calcium carbonate crystal type.

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Biomimetic mineralization of the carbonates regulated by using hydroxypropyl methylcellulose macromolecules as organic templates

Cited by 6 publications

References 38 publications

A Novel Mineralizing film Induces Biomimetic Mineralization

A Novel Mineralizing film Induces Biomimetic Mineralization

A Hydroxypropyl Methylcellulose Film Loaded with AFCP Nanoparticles for Inhibiting Formation of Enamel White Spot Lesions

Effects of Hydroxypropyl Methylcellulose (HPMC) on the Reinforcement of Sand by Microbial-Induced Calcium Carbonate Precipitation (MICP)

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