Biomimetic mineralization of nanocrystalline hydroxyapatites on aminated modified polylactic acid microspheres to develop a novel drug delivery system for alendronate

Chen, Shunyu; Guo, Rongying; Xie, Chunling; Liang, Qingshuang; Xiao, Xiufeng

doi:10.1016/j.msec.2020.110655

Cited by 30 publications

(10 citation statements)

References 33 publications

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“…Alendronate (ALN), a powerful bone resorption inhibitor with a high affinity for HA, is used to treat and prevent osteoporosis ( Chen S. et al, 2020 ). The phosphate of ALN exchanges with the phosphate of HA in enamel, forming coordination chains that tightly bind it to the enamel surface ( Palazzo et al, 2007 ).…”

Section: Functionalized Organic Materialsmentioning

confidence: 99%

Advanced materials for enamel remineralization

Shi

Luo

et al. 2022

Front. Bioeng. Biotechnol.

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Dental caries, a chronic and irreversible disease caused by caries-causing bacteria, has been listed as one of the three major human diseases to be prevented and treated. Therefore, it is critical to effectively stop the development of enamel caries. Remineralization treatment can control the progression of caries by inhibiting and reversing enamel demineralization at an early stage. In this process, functional materials guide the deposition of minerals on the damaged enamel, and the structure and hardness of the enamel are then restored. These remineralization materials have great potential for clinical application. In this review, advanced materials for enamel remineralization were briefly summarized, furthermore, an outlook on the perspective of remineralization materials were addressed.

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Section: Functionalized Organic Materialsmentioning

confidence: 99%

Advanced materials for enamel remineralization

Shi

Luo

et al. 2022

Front. Bioeng. Biotechnol.

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“…Second, polymers such as poly(vinyl alcohol) (PVA), [42] poly(ethylene glycol) (PEG), [43] PLA, [44] and polycaprolactone (PCL), [45] which have rare mineralization-functional groups, can be chemical modified or blended with mineralized polymers to improve their biomimetic mineralization capacity. For instance, amino and carboxyl groups can be introduced onto PLA [44] and PCL [45] chains by aminolysis with ethylenediamine and oxygen plasma treatment, respectively, which both have strong affinity toward Ca 2+ in solution and then improved in situ biomimeticaly mineralized deposition of HA on the surface of PLA/PCLbased scaffolds. Moreover, Tang and co-workers [42] reported a spider silk fiber (SSF)-like hybrid material composed of PVA, HA, and sodium alginate (Alg).…”

Section: Template Materials For Bmmentioning

confidence: 99%

Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

Xiang

et al. 2022

Advanced Materials

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Rebuilding mineralized tissues in skeletal and dental systems remains costly and challenging. Despite numerous demands and heavy clinical burden over the world, sources of autografts, allografts, and xenografts are far limited, along with massive risks including viral infections, ethic crisis, and so on. Per such dilemma, artificial scaffolds have emerged to provide efficient alternatives. To date, cell‐free biomimetic mineralization (BM) and cell‐dependent scaffolds have both demonstrated promising capabilities of regenerating mineralized tissues. However, BM and cell‐dependent scaffolds have distinctive mechanisms for mineral genesis, which makes them methodically, synthetically, and functionally disparate. Herein, these two strategies in regenerative dentistry and orthopedics are systematically summarized at the level of mechanisms. For BM, methodological and theoretical advances are focused upon; and meanwhile, for cell‐dependent scaffolds, it is demonstrated how scaffolds orchestrate osteogenic cell fate. The summary of the experimental advances and clinical progress will endow researchers with mechanistic understandings of artificial scaffolds in rebuilding hard tissues, by which better clinical choices and research directions may be approached.

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“…As a result, they can form spherical particles and avoid further agglomeration among particles. [ 58 ]…”

Section: Preparation Of Microspherementioning

confidence: 99%

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

Zhang

Wang

et al. 2020

Macro Materials & Eng

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Microspheres applied in medical applications experience explosive development in recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both in economy and technology lay that cannot be ignored. For instance, microsphere technology has not been used in cell culture widely because of its uneconomical cost; as the core of drug‐loaded microsphere, targeted microsphere technology is still not mature enough. Besides, the common microsphere fabrication methods: microfluidic or emulsion technology is difficult to guarantee high biocompatibility of microsphere due to utilization of photoinitiator, crosslinking agent, surfactant, and other substances. Therefore, gas‐shearing technology has been proposed to solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than on single microspheres which begins with a minute introduction of microsphere preparation methods: microfluidic, coaxial electrospray, emulsion, and gas‐shearing technology. Then its medical applications: drug release, cell culture, bone tissue engineering, and hemostasis are discussed in detail. The disadvantages of fabrication methods and bottlenecks for medical applications at present are also stated. At the end, perspectives of microsphere development are put forward.

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Biomimetic mineralization of nanocrystalline hydroxyapatites on aminated modified polylactic acid microspheres to develop a novel drug delivery system for alendronate

Cited by 30 publications

References 33 publications

Advanced materials for enamel remineralization

Advanced materials for enamel remineralization

Mechanistically Scoping Cell‐Free and Cell‐Dependent Artificial Scaffolds in Rebuilding Skeletal and Dental Hard Tissues

Preparation of Single, Heteromorphic Microspheres, and Their Progress for Medical Applications

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