Biomimetic mineralization of carboxymethyl chitosan nanofibers with improved osteogenic activity in vitro and in vivo

Zhao, Xiujuan; Zhou, Liangyu; Li, Qingtao; Zou, Qingxia; Du, Chang

doi:10.1016/j.carbpol.2018.04.090

Cited by 97 publications

(56 citation statements)

References 34 publications

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“…Table 2 shows the applications of common chitosan derivatives in bone tissue engineering. Increased pore size and mechanical properties promote osteoblast differentiation [61] Trimethyl chitosan N,N,N-trimethyl chitosan-heparin polyelectrolyte multilayer Bionic periosteum Good cell compatibility and support osteoblast differentiation [142] Hydroxypropyltrimethylammonium chloride chitosan Alginate/HACC/oyster shell powder Preparation bracket Improve mechanical properties and enhance stent surface area [143] CMCS is a commonly used in bone tissue engineering [137][138][139][140][141]. In addition to the applications shown in Table 2, CMCS can also be used to make nanofiber scaffolds [144].…”

Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

530

326

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“…Finally, the polymer jet solidifies in nanofibers upon hitting the collector surface [ 55 ]. Many researchers have applied this method for the preparation of a chitosan-based scaffold for tissue engineering [ 56 , 57 , 58 , 59 ]. For instance, Doan et al [ 56 ] prepared CS nanofibers with uniform diameters using electrospinning and then mineralized the nanofiber surfaces by a wet chemical process.…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…It generally takes 7–21 days [ 80 , 95 ]. Therefore, to shorten the immersion time, SBF solutions with different ion concentrations and various times were used, such as the 1.5 times SBF (a 1.5 times ionic concentration of SBF) [ 80 ], Modified SBF (a two-fold increase in the concentrations of calcium and phosphate ions, compared to SBF) [ 47 ], and 5 times SBF (a 5 times ionic concentration of SBF) [ 59 , 95 ]. AS is an artificial solution that has a similar composition to that of human saliva, its recipes are varied but Ca 2+ and PO 4 3− are always contained [ 96 ].…”

Section: Chitosan-based Biomimetically Mineralized Composite Matermentioning

confidence: 99%

“…Preparing organic-inorganic composite nanofibers to simulate the composition of the ECM is an effective strategy for providing bone tissue engineering scaffolds. According to the structure and composition of natural bone, natural macromolecule/HAP composite scaffolds synthesized by biomimetic mineralization with natural bioactive macromolecules are currently key research focuses in this field [ 59 , 106 , 107 ]. Among these macromolecules, chitosan is a popular alternative because of its excellent biological properties [ 108 ].…”

Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

“…Compared with ordinary chitosan, carboxymethyl chitosan (CMCS) has a better water-solubility, biodegradability, and bioactivity, which allows CMCS to chelate Ca 2+ and induce the deposition of apatite [ 109 , 110 ]. HAP-coated electro-spun CMCS nanofibers prepared by biomimetic mineralization using 5 times simulated body fluid increased the ALP activity and the gene expression level of Runx2 and ALP and promoted new bone formation and maturation [ 59 ]. In order to fabricate a hybrid nanostructured HAP-CS composite scaffold with HAP nanorods perpendicularly-oriented to CS fibers, Guo and his co-workers [ 44 ] applied a two-stage preparation process using brushite (DCPD, CaHPO 4 ·2H 2 O) as transitory precursors and mimicked the biomineralization process of the apatite in bone tissue.…”

Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

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Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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