Biomimetic microfluidic chips for toxicity assessment of environmental pollutants

Du, Xin-yue; Yang, Jin-yan

doi:10.1016/j.scitotenv.2024.170745

Cited by 2 publications

(1 citation statement)

References 255 publications

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“…Prior to the advent of microfluidics as a defined field, micro-sized channels were often contained within components of scientific and engineering instruments mostly unrelated to microfluidic applications (Ren et al, 2013;Convery and Gadegaard, 2019). Currently when compared with early microfluidics, microchannels with various geometries are used for many different applications and have huge potential for use within biomedical science (Ramachandraiah et al, 2017;David et al, 2019;Lu et al, 2019;Pritchard et al, 2019;Guzniczak et al, 2020;Xie et al, 2022), industrial processing (Estrada-Osorio et al, 2024;Jayan et al, 2024;Wang et al, 2024;Yi et al, 2024), environmental research (Hill et al, 2022;AlMashrea et al, 2024;Du and Yang, 2024;Sun et al, 2024) and increasingly reaching into other fields (Apoorva et al, 2024;Lei et al, 2024;Reyes et al, 2024). The manufacturing of these microchannels relies upon the use of appropriate techniques, equipment, and materials to produce microfluidic devices consistently and accurately (Ren et al, 2013;Gale et al, 2018;Scott and Ali, 2021;Akbari et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Categorising hybrid material microfluidic devices

Carvell,

Burgoyne,

Fraser

et al. 2024

Front. Lab. Chip. Technol.

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Microfluidic devices are useful tools for a wide range of biomedical, industrial, and environmental applications. Hybrid microfluidic devices utilising more than two materials are increasingly being used for their capacity to produce unique structures and perform novel functions. However, an analysis of publications across the field shows that whilst hybrid microfluidic devices have been reported, there remains no system of classifying hybrid devices which could help future researchers in optimising material selection. To resolve this issue, we propose a system of classifying hybrid microfluidic devices primarily as containing either hybrid structural, chemical, or electrical components. This is expanded upon and developed into a hierarchy, with combinations of different primary components categorised into secondary or tertiary hybrid device groupings. This classification approach is useful as it describes materials that can be combined to create novel hybrid microfluidic devices.

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Section: Introductionmentioning

confidence: 99%

Categorising hybrid material microfluidic devices

Carvell,

Burgoyne,

Fraser

et al. 2024

Front. Lab. Chip. Technol.

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Microfluidic flow tuning via asymmetric flow of nematic liquid crystal under temperature gradient

Li,

Yu,

Duan

et al. 2024

Physics of Fluids

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In this work, efficient microfluidic flow rate tuning based on the asymmetric flow of nematic liquid crystal 5CB under a horizontal temperature gradient is studied. Rectangular microchannels with the width of 100 μm are fabricated through soft lithography and treated with homeotropic surface anchoring conditions. Polarized optical microscopy is applied to explore the unique optical anisotropic characteristics of the nematic liquid crystal. The asymmetric velocity profiles in the microchannel are obtained by particle tracking velocimetry. The effects of temperature, flow rate, and aspect ratio on the velocity profile and split ratio of the asymmetric flow are quantitatively studied for the first time, while the mechanism of the flow asymmetry of the nematic liquid crystal is discussed. The results show that the asymmetric flow of the nematic liquid crystal occurs after the horizontal temperature gradient is applied, with the velocity in the heated region markedly higher than its counterpart. The split ratio of the asymmetric flow increases with the increase in the temperature gradient and the decrease in the flow rate. The aspect ratio influences the asymmetric flow through approaches of average velocity and surface anchoring strength, while the former is more distinct. The impacts of temperature gradient, flow rate, and aspect ratio on the flow asymmetry of nematic liquid crystals are caused by the coupling between physical properties, velocity field, and director field. Microchannels based on the asymmetric flow characteristics of nematic liquid crystals can act as a novel kind of temperature-controlled microvalve to achieve efficient microfluidic flow tuning.

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Biomimetic microfluidic chips for toxicity assessment of environmental pollutants

Cited by 2 publications

References 255 publications

Categorising hybrid material microfluidic devices

Categorising hybrid material microfluidic devices

Microfluidic flow tuning via asymmetric flow of nematic liquid crystal under temperature gradient

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