Biomimetic Magnetic Silk Scaffolds

Samal, Sangram Keshari; Dash, Mamoni; Shelyakova, Tatiana; Declercq, Heidi; Uhlarz, M.; Bañobre‐López, Manuel; Dubruel, Peter; Cornelissen, Maria; Herrmannsdörfer, T.; Rivas, José; Padeletti, G.; Smedt, Stefaan C. De; Braeckmans, Kevin; Kaplan, David L.; Dediu, V.

doi:10.1021/acsami.5b00529

Cited by 55 publications

(45 citation statements)

References 72 publications

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“…The incorporation of MNPs into natural and synthetic matrices mimicking body tissues provided the final structures with heating properties when exposed to AMFs, which were used either to deliver loaded drugs and grow factors or to induce magnetic gradients and mechanical effects that resulted in an enhancement of the angiogenesis and cell proliferation in the implanted regions. Magnetic hydroxyapatite (HA), gelatine, polycaprolactone, and silk are some of the natural materials utilized as hosts of MNPs for hyperthermia‐induced bone tissue engineering …”

Section: Representative Biomedical Applicationsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

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521

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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Section: Representative Biomedical Applicationsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

Self Cite

521

330

View full text Add to dashboard Cite

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“…Cardiac tissue engineering, as a vast interdisciplinary field, bridges the biochemical identity of the cells to their biophysical and engineering features. This interdisciplinary connection facilitates the growth of functional substitutes of lost or damaged heart . Application of scaffolds in the cell culture media, alongside biomolecules and stem cells, accelerates regeneration process.…”

Section: Introductionmentioning

confidence: 99%

“…Silk‐based biomaterials offer significant advantages for potential adipose tissue engineering applications . The promising properties of silk include favorable toughness and ductility, ease of surface modification, immunocompatibility, degradability, and biocompatibility . This material can be shaped in several forms, including micro/nanoﬁbers, ﬁlms, sponges, and hydrogels.…”

Section: Introductionmentioning

confidence: 99%

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are new generation of magnetic NPs, which are widely used in clinical and biomedical applications . The SPIONs are intensively studied due to their superparamagnetic properties, low toxicity, relative ease of functionalization, high coercivity, and low Curie temperature . Therefore, Fe 3 O 4 magnetic NPs have brought out some new kinds of biomedical applications, such as biosensors, contrasting agent in magnetic resonance imaging (MRI), localizer in therapeutic hyperthermia, magnetic targeted‐drug delivery systems, and tissue engineering scaffolds .…”

Section: Introductionmentioning

confidence: 99%

“…14 The promising properties of silk include favorable toughness and ductility, 3 ease of surface modification, immunocompatibility, degradability, and biocompatibility. 1,2 This material can be shaped in several forms, including micro/ nanofibers, 17,18 films, 19,20 sponges, and hydrogels. The amino acid sequence of SF contains repetitive Gly-Ala-Gly-Ala-GlySer repeats, which self-assemble into antiparallel β-sheet structures.…”

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confidence: 99%

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Incorporation of SPION‐casein core‐shells into silk‐fibroin nanofibers for cardiac tissue engineering

Nazari

Heirani‐Tabasi

Hajiabbas

et al. 2019

J of Cellular Biochemistry

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Mimicking the structure of extracellular matrix (ECM) of myocardium is necessary for fabrication of functional cardiac tissue. The superparamagnetic iron oxide nanoparticles (SPIONs, Fe3O4), as new generation of magnetic nanoparticles (NPs), are highly intended in biomedical studies. Here, SPION NPs (1 wt%) were synthesized and incorporated into silk‐fibroin (SF) electrospun nanofibers to enhance mechanical properties and topography of the scaffolds. Then, the mouse embryonic cardiac cells (ECCs) were seeded on the scaffolds for in vitro studies. The SPION NPs were studied by scanning electron microscope (SEM), X‐ray diffraction (XRD), and transmission electron microscope (TEM). SF nanofibers were characterized after incorporation of SPIONs by SEM, TEM, water contact angle measurement, and tensile test. Furthermore, cytocompatibility of scaffolds was confirmed by 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay. SEM images showed that ECCs attached to the scaffolds with elongated morphologies. Also, the real‐time PCR and immunostaining studies approved upregulation of cardiac functional genes in ECCs seeded on the SF/SPION‐casein scaffolds including GATA‐4, cardiac troponin T, Nkx 2.5, and alpha‐myosin heavy chain, compared with the ones in SF. In conclusion, incorporation of core‐shells in SF supports cardiac differentiation, while has no negative impact on ECCs' proliferation and self‐renewal capacity.

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Silk Fibroin Based Magnetic Nanocomposites for Actuator Applications

et al. 2020

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Recent technological and environmental advances are being redirected to develop technologies based on advanced materials that are not dependent on fossil fuels and/or critical elements. [1] Among them, smart materials showing piezoelectric, [2] piezoresistive, [3] photosensitive, [4] or magnetics properties, [5] among others, are particularly interesting for applications such as electronics, sensors, or actuators. Polymer composites stand out in the development of smart and multifunctional materials as polymer matrixes in which suitable fillers, i,e, metallic, ceramic, or magnetic micro/ nanoparticles, are incorporated, to tailor materials response toward specific applications. [6] Furthermore, those composites are often compatible with additive manufacturing technologies that enlarges their applicability. Different synthetic polymer matrices are being used in the development of polymer composites such as thermoplastics, thermosets or elastomers, but to reduce the processing and consumption of fossil fuels, biopolymers are increasingly being used. [7] Silk fibroin (SF) polymer has been investigated for biomedical, [8] energy storage, [9] and electronic applications [10] due to its excellent intrinsic characteristics. SF is a natural macromolecular protein produced in the specialized glades of Bombyx Mori silkworm. [11] SF is packed in cocoons and acts as shield versus foreign threats, solar radiation, temperature, humidity, parasites, and predators during the

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Biomimetic Magnetic Silk Scaffolds

Cited by 55 publications

References 72 publications

Advances in Magnetic Nanoparticles for Biomedical Applications

Advances in Magnetic Nanoparticles for Biomedical Applications

Incorporation of SPION‐casein core‐shells into silk‐fibroin nanofibers for cardiac tissue engineering

Silk Fibroin Based Magnetic Nanocomposites for Actuator Applications

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