Biomimetic-inspired synthesis of sporochartines through Diels–Alder reaction between enantiopure (−)-sporothriolide and (+)-trienylfuranol A

Abstract

A biomimetic-inspired synthesis of sporochartines A-D involving a [4+2] Diels-Alder cycloaddition between (-)-sporothriolide and (+)-trienylfuranol A is described. For this study, we have realized the first enantiopure total synthesis of...

Regio- and Chemoselective Double Allylic Substitution of Alkenyl vic-Diols

“…For that, product 2z was subjected to modified Julia olefination conditions. Dienyl-THF structures are particularly relevant as they can be found in various fungal metabolites and are also involved in the biosynthesis of diverse natural products …”