Biomimetic injectable hydrogel based on silk fibroin/hyaluronic acid embedded with methylprednisolone for cartilage regeneration

Phan, Vu To-Anh; Murugesan, Mohanapriya; Nguyen, P.P. Thanh; Luu, Cuong Hung; Le, Ngoc-Han Hoai; Nguyen, Huong; Manivasagan, Panchanathan; Jang, Eue‐Soon; Li, Yang; Thambi, Thavasyappan

doi:10.1016/j.colsurfb.2022.112859

Cited by 16 publications

(8 citation statements)

References 57 publications

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“…SF plays a unique role in improving the mechanical properties of other materials. Phan et al [56] developed an injectable SF-HA scaffold system. The interaction of the materials results in a porous structure with a dense internal structure.…”

Section: Proteinsmentioning

confidence: 99%

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

Wang

Shi

Lin

et al. 2023

Macromolecular Bioscience

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Numerous factors, such as degeneration and accidents, frequently cause cartilage deterioration. Owing to the absence of blood vessels and nerves in cartilage tissue, the ability of cartilage tissue to heal itself after an injury is relatively low. Hydrogels are beneficial for cartilage tissue engineering owing to their cartilage‐like structure and advantageous properties. Due to the disruption of its mechanical structure, the bearing capacity and shock absorption of cartilage are diminished. The tissue should possess excellent mechanical properties to ensure the efficacy of cartilage tissue repair. This paper discusses the application of hydrogels in the fields of cartilage repair, the mechanical properties of hydrogels used for cartilage repair, and the materials used for hydrogels in cartilage tissue engineering. In addition, the challenges faced by hydrogels and future research directions are discussed.

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Section: Proteinsmentioning

confidence: 99%

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

Wang

Shi

Lin

et al. 2023

Macromolecular Bioscience

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“…Hyaluronic acid (HA) is conducive to the survival of chondrocytes and the formation of an ECM. SF-HA gel can be cross-linked by forming Schiff bases between SF and HA, and the resulting HA is more stable and adhesive [48]. Methylprednisolone (MP), which is easily digested in the joint cavity, can be embedded in SF-HA hydrogel.…”

Section: Treatment Of Osteoarthritis By Embedding Drugsmentioning

confidence: 99%

“…Methylprednisolone (MP), which is easily digested in the joint cavity, can be embedded in SF-HA hydrogel. The resulting MP-containing SF-HA gel can control the sustained release of MP, reduce inflammation for a long time, and create a good environment for the regeneration of chondrocytes [48]. In addition to MP, Song et al improved the efficacy of bone marrow stimulation by embedding Etanercept (Ept), which is a clinically used anti-rheumatic drug.…”

Section: Treatment Of Osteoarthritis By Embedding Drugsmentioning

confidence: 99%

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Lyu

Liu

et al. 2023

Gels

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Silk fibroin (SF) is an excellent protein-based biomaterial produced by the degumming and purification of silk from cocoons of the Bombyx mori through alkali or enzymatic treatments. SF exhibits excellent biological properties, such as mechanical properties, biocompatibility, biodegradability, bioabsorbability, low immunogenicity, and tunability, making it a versatile material widely applied in biological fields, particularly in tissue engineering. In tissue engineering, SF is often fabricated into hydrogel form, with the advantages of added materials. SF hydrogels have mostly been studied for their use in tissue regeneration by enhancing cell activity at the tissue defect site or counteracting tissue-damage-related factors. This review focuses on SF hydrogels, firstly summarizing the fabrication and properties of SF and SF hydrogels and then detailing the regenerative effects of SF hydrogels as scaffolds in cartilage, bone, skin, cornea, teeth, and eardrum in recent years.

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“…However, its rapid degradation and clearance from the body can limit its effectiveness in providing long-term therapeutic benefits [ 95 , 96 ]. Additionally, HA’s inherent low mechanical strength may restrict its use in load-bearing applications or environments where mechanical integrity is crucial [ 97 , 98 , 99 ].…”

Section: Ha As a Powerful Bioactive Moleculementioning

confidence: 99%

“…Specifically, the presence of acetyl groups in acetylated HA scaffolds led to a decrease in negative charges within the molecule and helped balance the osmotic pressure, making it comparable to that of the natural ECM cartilage. This reasonable osmotic pressure contributed to the creation of an environment that was conducive to chondrogenesis [ 97 , 98 ].…”

Section: Ha As a Powerful Bioactive Moleculementioning

confidence: 99%

Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

Iaconisi,

Lunetti,

Gallo

et al. 2023

IJMS

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Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions. Due to its biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, several HA-based biomedical products have been developed. There is an increasing focus on optimizing HA production processes to achieve high-quality, efficient, and cost-effective products. This review discusses HA’s structure, properties, and production through microbial fermentation. Furthermore, it highlights the bioactive applications of HA in emerging sectors of biomedicine.

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Biomimetic injectable hydrogel based on silk fibroin/hyaluronic acid embedded with methylprednisolone for cartilage regeneration

Cited by 16 publications

References 57 publications

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair

Application of Silk-Fibroin-Based Hydrogels in Tissue Engineering

Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

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