Biomimetic Hydrogels Promote Pseudoislet Formation to Improve Glycemic Control in Diabetic Mice
Shajun Zhu,
Yang Xu,
Yuxi Li
et al.
Abstract:Islet
or β-cell transplantation is currently considered to
be the ideal treatment for diabetes, and three-dimensional (3D) bioprinting
of a bionic pancreas with physiological stiffness is considered to
be promising for the encapsulation and transplantation of β-cells.
In this study, a 5%GelMA/2%AlgMA hybrid hydrogel with pancreatic physiological
stiffness was constructed and used for β-cell encapsulation,
3D bioprinting, and in vivo transplantation to evaluate glycemic control
in diabetic mice. The hybrid hydr… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.