Biomimetic Hybrid Systems for Tissue Engineering

Yousefzade, Omid; Katsarava, Ramaz; Puiggalı́, Jordi

doi:10.3390/biomimetics5040049

Cited by 21 publications

(17 citation statements)

References 175 publications

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“…They were especially useful for tissue repair. Many other polymers such as chitosan, alginate, and silk fibroin have been explored for the production of healing mechanisms due to their biodegradability, drug release ability, acceptable hydrophilicity, and non-toxicity [ 188 , 189 , 190 , 191 , 192 , 193 ]. From the animal resource, a polymer solution is developed.…”

Section: Innovation In Biomimetic Design Materials Properties Anmentioning

confidence: 99%

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

et al. 2021

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Over the last twenty years, researchers have focused on the potential applications of electrospinning, especially its scalability and versatility. Specifically, electrospun nanofiber scaffolds are considered an emergent technology and a promising approach that can be applied to biosensing, drug delivery, soft and hard tissue repair and regeneration, and wound healing. Several parameters control the functional scaffolds, such as fiber geometrical characteristics and alignment, architecture, etc. As it is based on nanotechnology, the concept of this approach has shown a strong evolution in terms of the forms of the materials used (aerogels, microspheres, etc.), the incorporated microorganisms used to treat diseases (cells, proteins, nuclei acids, etc.), and the manufacturing process in relation to the control of adhesion, proliferation, and differentiation of the mimetic nanofibers. However, several difficulties are still considered as huge challenges for scientists to overcome in relation to scaffolds design and properties (hydrophilicity, biodegradability, and biocompatibility) but also in relation to transferring biological nanofibers products into practical industrial use by way of a highly efficient bio-solution. In this article, the authors review current progress in the materials and processes used by the electrospinning technique to develop novel fibrous scaffolds with suitable design and that more closely mimic structure. A specific interest will be given to the use of this approach as an emergent technology for the treatment of bacteria and viruses such as COVID-19.

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Section: Innovation In Biomimetic Design Materials Properties Anmentioning

confidence: 99%

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

et al. 2021

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Section: Hybrid Systems For Drug Delivery and Tissue Engineeringmentioning

confidence: 99%

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Demirci¹,

Niedźwiedź²,

Kantor-Malujdy³

et al. 2021

Preprint

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Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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“…Since stem/progenitor cells residing in the periosteum and endosteum have a limited potential to repair bone damage, stimulating the endogenous regenerative process with an innovative approach such as tissue engineering seems to be a promising strategy [ 2 , 3 , 4 , 5 , 6 , 7 ]. Bone tissue engineering strategy combines three essential components such as scaffolds, mesenchymal stem cells (MSCs) and growth factors, and is based on the culture of stem or progenitor cells on scaffolds in order to generate new bone by osteoinductive cues [ 3 , 6 , 7 , 8 , 9 ]. Generally, the mesenchymal stem cells isolated from bone marrow (BM-MSCs) are the main source of cells for bone tissue engineering, but there still exist concerns regarding their osteogenic efficiency [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several bi-dimensional (2D) and three-dimensional (3D) natural and synthetic scaffolds and their mixed components blends have been tested for bone tissue engineering, but an ideal scaffold is not yet developed due to the fundamental requirement for tissue-engineered bone grafts, which enables the ability to integrate with the host tissues and promote their repair [ 8 , 9 , 10 ]. Scaffold design for bone tissue engineering involves many parameters such as physical, mechanical, chemical and biological factors that affect scaffold properties and have an impact on stem cells behavior [ 8 , 9 , 11 ]. It was found that 2D scaffolds are unable to support in vitro cell growth and organization in a tissue-like structure because of the lack of the extracellular matrix (ECM) providing a three-dimensional (3D) microenvironment for the cells in vivo [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a scaffold for bone tissue engineering should induce angiogenesis because new blood vessel formation is necessary for nutrients and oxygen transport [ 11 , 22 ]. Usually, scaffolds developed for bone tissue engineering try to mimic the natural matrix, and the most frequently used are natural and synthetics polymers, ceramics and composites [ 8 , 9 , 11 , 23 ]. Natural polymers consist of proteins, and among the natural polymers, collagen is most frequently used as a matrix in bone regeneration [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold

et al. 2022

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Poly(L-lactide-co-caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold. The hDPSCs were seeded on PLCL, and their biological features such as viability, proliferation, adhesion, population doubling time, the immunophenotype of hDPSCs and osteogenic differentiation capacity were evaluated on scaffolds. The results showed that the PLCL scaffold significantly supported hDPSC viability/proliferation. The hDPSCs adhesion rate and spreading onto PLCL increased with time of culture. hDPSCs were able to migrate inside the PLCL electrospun scaffold after 7 days of seeding. No differences in morphology and immunophenotype of hDPSCs grown on PLCL and in flasks were observed. The mRNA levels of bone-related genes and their proteins were significantly higher in hDPSCs after osteogenic differentiation on PLCL compared with undifferentiated hDPSCs on PLCL. These results showed that the mechanical properties of a modified PLCL mat provide an appropriate environment that supports hDPSCs attachment, proliferation, migration and their osteogenic differentiation on the PLCL scaffold. The good PLCL biocompatibility with dental pulp stem cells indicates that this mat may be applied in designing a bioactive hDPSCs/PLCL construct for bone tissue engineering.

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Biomimetic Hybrid Systems for Tissue Engineering

Cited by 21 publications

References 175 publications

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

Electrospun Nanofibrous Scaffolds: Review of Current Progress in the Properties and Manufacturing Process, and Possible Applications for COVID-19

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold

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