Biomimetic engineering endothelium-like coating on cardiovascular stent through heparin and nitric oxide-generating compound synergistic modification strategy

Qiu, Hua; Qi, Pengkai; Liu, Jing‐Xia; Yang, Ying; Tan, Xing; Xiao, Yu; Maitz, Manfred F.; Huang, Nan; Yang, Zhilu

doi:10.1016/j.biomaterials.2019.03.033

Cited by 121 publications

(83 citation statements)

References 53 publications

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“…The combining glycocalyx-inspired features of nanostructured surfaces, polysaccharide-based multilayers, and NO-donor chemistry endowed biomaterials surface with multiple functions. In our recent study, the sequential conjugation of heparin and selenocystamine onto an aminebearing film was also developed [21]. However, generating a new biomedical device coating with therapeutic delivery property should not only include the off-target effects and duration of delivery but also potential side effects and coating longevity.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the stenting process inevitably damages ECs, accompanied by impaired eNOS activity and insufficient NO production [18]. Although numerous NO-releasing/generating coatings, mostly by introducing NO supplier or catalyzer (like N-diazeniumdiolate or ascorbic acid) [10,19,20], have been developed to restore EC functions, these strategies have potential issues including the indetermination on precise therapeutic dosage as well as short half-life of NO supplier [21,22]. Moreover, the amount of released NO may be compromised when deactivated by reactive oxygen species (ROS) during the EC repopulation after stenting.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have integrated HS with ECderived NO catalyzer to modify cardiovascular stent surfaces to reduce thrombus, enhance reendothelialization, and inhibit SMC proliferation [21,[25][26][27][28][29][30][31][32][33]. However, these cardiovascular stent coatings still suffer from weaknesses including the following: (1) the amount of integrated heparin and their physiological functions are compromised due to the limited surface anchoring sites (insufficient surface amine functional groups) [21]; (2) the NO release dosage is difficult to control: NO release normally exhibits an initial burst release (causes potential cytotoxic and mutagenic issues), followed by a short-term release (i.e., 4 weeks) at physiologically relevant levels, limiting their long-term clinical success (treatment no less than 6 months, suggested by clinical guidelines) [31,34]; (3) the coatings which display synergistic heparin and NO generation properties usually have a thickness of a hundred micrometers [30,32,33]. Such thick layer artificially reduces the lumen area of blood vessels; additionally, they are often associated with insufficient flexibility and mechanical properties as well as weak adhesive strength to the stent surface.…”

Section: Introductionmentioning

confidence: 99%

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Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

et al. 2020

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Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelialization, thus leading to restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal (copper)-catechol-(amine) (MCA) surface chemistry strategy, leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization. Apart from the stable nitric oxide (NO) generating rate at the physiological level (2.2×10−10 mol/cm2/min lasting for 60 days), this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to ∼1 μg/cm2, which is considerably higher than most of the conventional heparinized surfaces. The resultant coating could create an ideal microenvironment for bringing in enhanced anti-thrombogenicity, anti-inflammation, anti-proliferation of smooth muscle cells, re-endothelialization by regulating relevant gene expressions, hence preventing restenosis in vivo. We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

et al. 2020

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“…In this study, we constructed an ex-vivo blood circulation model ( Fig. 4 (A)) to further evaluate the anticoagulant property of the material in an environment closer to the in vivo environment [ 34 ]. As shown in Fig.…”

Section: Results and Disscusionmentioning

confidence: 99%

Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Jiang

Dai

Liu

et al. 2021

Bioactive Materials

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Titanium dioxide (TiO 2 ) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO 2 also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, also anti-inflammatory, anti-hyperplastic properties, and the ability to support endothelial repair, are desired. To meet these requirements, here, we immobilized silver nanoparticles (AgNPs) on the surface of TiO 2 nanotubes (TiO 2 -NTs) to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties. The photo-functionalized TiO 2 -NTs showed protein-fouling resistance, causing the anticoagulant property and the ability to suppress cell adhesion. The immobilized AgNPs increased the photocatalytic activity of TiO 2 -NTs to enhances its photo-induced anticoagulant property. The AgNP density was optimized to endow the TiO 2 -NTs with anti-inflammatory property, a strong inhibitory effect on smooth muscle cells (SMCs), and low toxicity to endothelial cells (ECs). The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO 2 -NTs and the multifunctional AgNPs, and therefore has enormous potential in the field of cardiovascular implant devices. Our research could be a useful reference for further designing of multifunctional TiO 2 materials with high vascular biocompatibility.

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“…favorable microenvironment for ECs over SMCs. [266] The coimmobilization of SeCA and REDV-containing peptide on Ti-O surface can selectively attach ECs over SMCs. The dual functionalized surface significantly enhanced endothelialization and alleviated neointimal hyperplasia in vivo.…”

Section: Chemical Approachmentioning

confidence: 99%

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

Zhao

Feng

2020

Adv Healthcare Materials

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Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular diseases. However, poor hemocompatibility and slow endothelialization on their surface still exist. Numerous surface engineering strategies have mainly sought to modify the device surface through physical, chemical, and biological approaches to improve surface hemocompatibility and endothelialization. The alteration of physical characteristics and pattern topographies brings some hopeful outcomes and plays a notable role in this respect. The chemical and biological approaches can provide potential signs of success in the endothelialization of vascular device surfaces. They usually involve therapeutic drugs, specific peptides, adhesive proteins, antibodies, growth factors and nitric oxide (NO) donors. The gene engineering can enhance the proliferation, growth, and migration of vascular cells, thus boosting the endothelialization. In this review, the surface engineering strategies are highlighted and summarized to improve hemocompatibility and rapid endothelialization on the cardiovascular devices. The potential outlook is also briefly discussed to help guide endothelialization strategies and inspire further innovations. It is hoped that this review can assist with the surface engineering of cardiovascular devices and promote future advancements in this emerging research field.

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Biomimetic engineering endothelium-like coating on cardiovascular stent through heparin and nitric oxide-generating compound synergistic modification strategy

Cited by 121 publications

References 53 publications

Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy

Photo-functionalized TiO2 nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility

Surface Engineering of Cardiovascular Devices for Improved Hemocompatibility and Rapid Endothelialization

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