Biomimetic Cryptic Site Surfaces for Reversible Chemo- and Cyto-Mechanoresponsive Substrates

Bacharouche, Jalal; Badique, Florent; Fahs, Ahmad; Spanedda, Maria Vittoria; Geissler, Alexandre; Malval, Jean‐Pierre; Vallat, Marie‐France; Anselme, Karine; Francius, Grégory; Frisch, Benoı̂t; Hemmerlé, Joseph; Schaaf, Pierre; Roucoules, Vincent

doi:10.1021/nn400356p

Cited by 24 publications

(21 citation statements)

References 26 publications

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“…Firstly, NPs allow higher tumor accumulation of encapsulated drugs by the enhanced permeability and retention (EPR) effect [28]. Secondly, NPs may further increase the tumor-targeted delivery by modification of the surface of NPs with specific tumor cell targeting ligands, such as folic acid, biotin, and antibodies [29–32]. Additionally, NPs can deliver multiple types of agents with different anticancer mechanisms such as a chemotherapeutic drug with a chemosensitizer, to exert synergistic anticancer effects [33–36].…”

Section: Introductionmentioning

confidence: 99%

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Liu

Chen

et al. 2016

Oncotarget

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The combination of a chemotherapeutic drug with a chemosensitizer has emerged as a promising strategy for cancers showing multidrug resistance (MDR). Herein we describe the simultaneous targeted delivery of two drugs to tumor cells by using biotin-decorated poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles encapsulating the chemotherapeutic drug doxorubicin and the chemosensitizer quercetin (BNDQ). Next, the potential ability of BNDQ to reverse MDR in vitro and in vivo was investigated. Studies demonstrated that BNDQ was more effectively taken up with less efflux by doxorubicin-resistant MCF-7 breast cancer cells (MCF-7/ADR cells) than by the cells treated with the free drugs, single-drug–loaded nanoparticles, or non-biotin–decorated nanoparticles. BNDQ exhibited clear inhibition of both the activity and expression of P-glycoprotein in MCF-7/ADR cells. More importantly, it caused a significant reduction in doxorubicin resistance in MCF-7/ADR breast cancer cells both in vitro and in vivo, among all the groups. Overall, this study suggests that BNDQ has a potential role in the treatment of drug-resistant breast cancer.

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Section: Introductionmentioning

confidence: 99%

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Liu

Chen

et al. 2016

Oncotarget

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“…The presence of the reactive anhydride group in MAPP films makes possible its uses for surface functionalization and adhesion improvement, biocompatibility and biomedical applications, and development of (nano)patterned surfaces …”

Section: Introductionmentioning

confidence: 99%

Controlling the Morphogenesis of Needle-Like and Multibranched Structures in Maleic Anhydride Plasma Polymer Thin Films

Brioude

Laborie

Airoudj

et al. 2014

Plasma Process. Polym.

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We report for the first time the formation of spherical and branched structures when polymerizing maleic anhydride under very low power with pulsed plasma polymerization. A factorial experimental design evidenced duty cycle, frequency and their interactions as decisive factors for the formation and growth of these structures. A mechanism involving the decoupling of deposition (nucleation) and diffusion rates of active species was proposed to relate structure formation to processing parameters. While differences in surface chemistry were not detectable by surface spectroscopy (PM‐IRRAS, XPS), AFM force measurements on a carefully designed sample evidenced differences in adhesion and thus surface chemistry between the different film morphologies.

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“…Recently, mechano-activated surfaces have gained interest based on concepts of opening of cryptic sites in proteins. 37 , 38 …”

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confidence: 99%

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Roberts

Sahoo²,

McNamara

et al. 2016

ACS Nano

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Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Traditional cell culture techniques have fallen short of meeting this challenge, but materials science offers hope. In this study, we have used emerging rules of managing adhesion/cytoskeletal balance to prolong MSC cultures by fabricating controllable nanoscale cell interfaces using immobilized peptides that may be enzymatically activated to change their function. The surfaces can be altered (activated) at will to tip adhesion/cytoskeletal balance and initiate differentiation, hence better informing biological mechanisms of stem cell growth. Tools that are able to investigate the stem cell phenotype are important. While large phenotypical differences, such as the difference between an adipocyte and an osteoblast, are now better understood, the far more subtle differences between fibroblasts and MSCs are much harder to dissect. The development of technologies able to dynamically navigate small differences in adhesion are critical in the race to provide regenerative strategies using stem cells.

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Biomimetic Cryptic Site Surfaces for Reversible Chemo- and Cyto-Mechanoresponsive Substrates

Cited by 24 publications

References 26 publications

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Controlling the Morphogenesis of Needle-Like and Multibranched Structures in Maleic Anhydride Plasma Polymer Thin Films

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

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