Biomimetic composite scaffold from an <i>in situ</i> hydroxyapatite coating on cellulose nanocrystals

Huang, Chen; Bhagia, Samarthya; Hao, Naijia; Meng, Xianzhi; Liang, Luna; Yong, Qiang; Ragauskas, Arthur J.

doi:10.1039/c8ra09523j

Cited by 39 publications

(21 citation statements)

References 54 publications

(70 reference statements)

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“…Phase structures and functional groups of the composite scaffolds were characterized by XRD patterns and FTIR spectra, respectively. The characteristic peak at around 17° in the XRD spectra could be ascribed to PLLA [ 36 ], as shown in Fig. 2 (a).…”

Section: Resultsmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

266

124

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The incorporation of hydroxyapatite (HAP) into poly- l -lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity to those of the living bone. While too low degradation rate of HAP/PLLA scaffold hinders the activity because the embedded HAP in the PLLA matrix is difficult to contact and exchange ions with body fluid. In this study, biodegradable polymer poly (glycolic acid) (PGA) was blended into the HAP/PLLA scaffold fabricated by laser 3D printing to accelerate the degradation. The results indicated that the incorporation of PGA enhanced the degradation rate of scaffold as indicated by the weight loss increasing from 3.3% to 25.0% after immersion for 28 days, owing to the degradation of high hydrophilic PGA and the subsequent accelerated hydrolysis of PLLA chains. Moreover, a lot of pores produced by the degradation of the scaffold promoted the exposure of HAP from the matrix, which not only activated the deposition of bone like apatite on scaffold but also accelerated apatite growth. Cytocompatibility tests exhibited a good osteoblast adhesion, spreading and proliferation, suggesting the scaffold provided a suitable environment for cell cultivation. Furthermore, the scaffold displayed excellent bone defect repair capacity with the formation of abundant new bone tissue and blood vessel tissue, and both ends of defect region were bridged after 8 weeks of implantation.

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Section: Resultsmentioning

confidence: 99%

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Shuai

Yang

Feng

et al. 2021

Bioactive Materials

266

124

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“…The second step, between 250°C and 350°C, is related to the thermal degradation of the backbone chains of the polymer matrix. Taking into consideration that the CaP phase is stable at 700°C [27], the quantification of residual masses allows to assess the precise composition of the composites. For neat polymers, the remaining amount found at 700°C can be probably related to the formation of coke residue during thermal polymer degradation as demonstrated in previous works [28, 29].…”

Section: Resultsmentioning

confidence: 99%

In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels

D’Amora

Ronca

Raucci

et al. 2019

Regenerative Biomaterials

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The main driving idea of the present study was the comparison between two different chemical modifications of hyaluronic acid (HA) followed by the development of nanocomposite hydrogels directly in situ by biomineralization of photocrosslinkable HA polymers through sol-gel synthesis. In this way, it has been possible to overcome some limitations due to classical approaches based on the physical blending of inorganic fillers into polymer matrix. To this aim, methacrylated and maleated HA, synthesized with similar degree of substitution (DS) were compared in terms of mechanical and physico-chemical properties. The success of in situ biomineralization was highlighted by reflect Fourier transform infrared spectroscopy and thermogravimetric analysis. Furthermore, mechanical characterization demonstrated the reinforcing effect of inorganic fillers evidencing a strong correlation with DS. The swelling behavior resulted to be correlated with filler concentration. Finally, the cytotoxicity tests revealed the absence of toxic components and an increase of cell proliferation over culture time was observed, highlighting these bio-nanocomposite hyaluronan derivatives as biocompatible hydrogel with tunable properties.

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“…Different types of 3D scaffolds have been developed inspired by the intrinsic relationship between human bone and HA to highlight the drawbacks of currently used bone substitutes. [ 84,242 ] Biomimetic nanocomposites based on cellulose and HA are promising biomaterials for bone tissue engineering. Transmission electron microscopy (TEM) of various nanocellulose substrates for HA crystallization is displayed in Figure .…”

Section: Counterions Multivalent Cations and Associated Mineralizationmentioning

confidence: 99%

“…Transmission electron microscopy (TEM) of various nanocellulose substrates for HA crystallization is displayed in Figure . [ 242–245 ] Huang et al developed a facile approach (via pH adjustment) to coat HA on CNC in a simulated body fluid. Generally, pH control rather than CNC surface modification is more effective in HA formation (highest HA formation at pH 9) (Figure 15a 1 ,a 2 ).…”

Section: Counterions Multivalent Cations and Associated Mineralizationmentioning

confidence: 99%

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

et al. 2020

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Recent developments in the area of plant‐based hydrogels are introduced, especially those derived from wood as a widely available, multiscale, and hierarchical source of nanomaterials, as well as other cell wall elements. With water being fundamental in a hydrogel, water interactions, hydration, and swelling, all critically important in designing, processing, and achieving the desired properties of sustainable and functional hydrogels, are highlighted. A plant, by itself, is a form of a hydrogel, at least at given states of development, and for this reason phenomena such as fluid transport, diffusion, capillarity, and ionic effects are examined. These aspects are highly relevant not only to plants, especially lignified tissues, but also to the porous structures produced after removal of water (foams, sponges, cryogels, xerogels, and aerogels). Thus, a useful source of critical and comprehensive information is provided regarding the synthesis of hydrogels from plant materials (and especially wood nanostructures), and about the role of water, not only for processing but for developing hydrogel properties and uses.

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Biomimetic composite scaffold from an in situ hydroxyapatite coating on cellulose nanocrystals

Abstract: A novel nanocomposite scaffold was developed by homogeneous deposition of hydroxyapatite (HAP) on a cellulose nanocrystal (CNCs) matrix suspended in a simulated body fluid (SBF).

Cited by 39 publications

References 54 publications

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

In situ sol-gel synthesis of hyaluronan derivatives bio-nanocomposite hydrogels

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

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