Biomimetic coating technology for orthopedic implants

Koju, Naresh; Sikder, Prabaha; Ren, Yufu; Zhou, Huan; Bhaduri, Sarit B.

doi:10.1016/j.coche.2016.11.005

Cited by 73 publications

(35 citation statements)

References 51 publications

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“…On the other hand, limited apatite formation is expected from positive charges on the surface as they attract antiadhesive anionic groups such as HPO 4 2− and HCO 3 2− [ 54 ]. There are instances in the literature where apatite formation was accelerated by using a higher concentration of SBF [ 55 ]. The colloidal silica is also responsible for apatite nucleation and growth [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

et al. 2018

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The present study is the first of its kind dealing with the development of a specific bioceramic which qualifies as a potential material in hard-tissue replacements. Specifically, we report the synthesis and evaluation of smart injectable calcium phosphate bone cement (CPC) which we believe will be suitable for various kinds of orthopedic and spinal-fusion applications. The smart nature of this next generation orthopedic implant is attained by incorporating piezoelectric barium titanate (BT) particles into monetite-based (dicalcium phosphate anhydrous, DCPA) CPC composition. The main goal is to take advantage of the piezoelectric properties of BT, as electromechanical effect plays a vital role in fracture healing at the defect site and bone integration with the implant. Furthermore, radiopacity of BT would help in easy detection of the CPC presence at the fracture site during surgery. Results reveal that BT addition favors important properties of bone cement such as good compressive strength, injectability, bioactivity, biocompatibility, and even washout resistance. Most importantly, the self-setting nature of the bone cements are not compromised with BT incorporation. The in vitro results confirm that the developed bone-cement abides by the standard orthopedic requirements making it apt for real-time prosthetic materials.

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Section: Discussionmentioning

confidence: 99%

Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

et al. 2018

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“…In clinical practice, it is used in the form of powders or granules as filler for bone replacement or for repair of post-resection defects [4,5]. HA is also successfully used as a coating material for metallic implants due to its bioactivity and favourable effects on the osseointegration process [6]. Porous structures may be used as temporary scaffolds for newly formed osseous tissue.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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“…The soaking process most generally used to produce CaP coatings on metallic [19,20] or polymeric implants [21,22], or to form inorganic/organic composites [23,24], often involves simulated body fluid (SBF), a metastable supersaturated solution with the ability to precipitate only a minute amount of CaP salt (∼150 mg of apatite per liter of solution at best). In addition, this process can take several hours or days to obtain a coating, depending on the crystal nucleation ability of the surface to coat [25]. To increase the deposition kinetics and the amount of CaP formed, some studies have been completed with higher ion concentrations (SBF ×2, ×5 or ×10) [17,19,26].…”

Section: Introductionmentioning

confidence: 99%

Calcium phosphate coatings elaborated by the soaking process on titanium dental implants: Surface preparation, processing and physical–chemical characterization

et al. 2019

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Biomimetic coating technology for orthopedic implants

Cited by 73 publications

References 51 publications

Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

Smart Injectable Self-Setting Monetite Based Bioceramics for Orthopedic Applications

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Calcium phosphate coatings elaborated by the soaking process on titanium dental implants: Surface preparation, processing and physical–chemical characterization

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