Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Adawy, Alaa; Abdel-Fattah, Wafa I.; El-Sayed, El-Sayed M; Talaat, M.S.

doi:10.2174/1875181400901010019

Cited by 12 publications

(17 citation statements)

References 40 publications

(67 reference statements)

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“…1, 2). All peaks were within the same positions as that of mother sample [24]. In general, the optical density of all the peaks in Sr-c-SBF, (Fig.…”

Section: Days Soakingmentioning

confidence: 57%

“…All samples have the same dimensions: 29.2mm 3 volume, 64.7mm 2 total surface area and 0.22 gm ±0.01gm weight. They were activated according to the author's previous protocol [24]. Briefly, their surfaces were roughened to an average of 35μm, ultrasonically cleaned, alkali and heat treated and subsequently precalcified.…”

Section: Methodsmentioning

confidence: 99%

“…In our approach, they exceed the ionic concentration of the ordinary c-SBF by one half, i.e., 1.5 c-SBF. The same receipt of our previous research [24] was used in the current work. The incorporation of strontium or zinc ions into the biomimetic solutions was maintained by the supplement of 0.5mM of Sr or Zn through addition of adequate amounts of SrCl 2 .6H 2 O (E. merck, Darmstadt, cryst.…”

Section: Preparation Of Sbfmentioning

confidence: 99%

“…Spectral resolution is 0.5 cm -1 and accuracy is within ± 0.01 cm -1 . Reflectance spectra of the pretreated samples were previously studied [24]. It is supposed that any decrement occur in the solution ions' concentration, is deposition onto sample surface.…”

Section: Characterizationsmentioning

confidence: 99%

“…The pretreated sample denoted as SAHPC [24], was used as the initial substrates in this procedure. The samples' codes are given in Table 2.…”

Section: Driftsmentioning

confidence: 99%

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Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Abdel-Fattah¹,

El-Sayed²,

Talaat³

et al. 2011

Open Biomat J

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Abstract:The next great wave of innovation and development for implantable medical devices focuses on surface engineering. This would enhance their performance, restore lost functions and ultimately reduce pain. Biomimetic coating is a promising approach, used in that concern. In the present work, an attempt was made to develop the function of the biomimetic coating rather than the classical biocompatibility. Corrected simulated body fluid, leading the conventional fluid concentration by one half, 1.5 c-SBF, was prepared with adequate supplement of Sr +2 , or Zn +2 according to the permissible therapeutic doses, 0.5 mM. The selection of Sr +2 and Zn +2 as additives was owing to their anti-osteoporotic and antimicrobial/bacterial activity respectively. The bioinert discs of titanium aluminum vanadium alloy, Ti-6Al-4V, were pretreated according to our previously developed protocol [Alaa Adawy et al. 2009, Biomimetic Coating of Precalcified Ti-6Al-4V Alloy, J. Open Medical Devices, 1 (2009)19]. Subsequently, they were soaked in the prepared SBFs. Stepwise surface characterization was assessed using Diffuse Reflectance Infra-red Fourier Transform Spectroscopy, DRIFTS. In parallel, the remnants of the soaking solutions were analyzed chemically by atomic absorption and biochemical kits, and physically by AC electrical conductivity measurements at room temperature. Scanning electron microscopy, SEM, was used to assess surface final morphology post the whole treatment duration. Incorporation of Sr +2and Zn +2 resulted in the growth of calcium deficient apatite of high carbonate content. The former increased the activity of biomimetic deposition while the latter induced more uniformity in the resultant coating.

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“…1, 2). All peaks were within the same positions as that of mother sample [24]. In general, the optical density of all the peaks in Sr-c-SBF, (Fig.…”

Section: Days Soakingmentioning

confidence: 57%

Section: Methodsmentioning

confidence: 99%

Section: Preparation Of Sbfmentioning

confidence: 99%

Section: Characterizationsmentioning

confidence: 99%

“…The pretreated sample denoted as SAHPC [24], was used as the initial substrates in this procedure. The samples' codes are given in Table 2.…”

Section: Driftsmentioning

confidence: 99%

See 3 more Smart Citations

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Abdel-Fattah¹,

El-Sayed²,

Talaat³

et al. 2011

Open Biomat J

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Technology of Coating Deposition

Heimann

Lehmann²

2015

Bioceramic Coatings for Medical Implants

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Amino acid surface modified bioglass: A candidate biomaterial for bone tissue engineering¹

Özkabadayı,

Türk,

Kumandaş

et al. 2024

Microscopy Res & Technique

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Bioglasses are solid materials consisted of sodium oxide, calcium oxide, silicon dioxide and phosphorus in various proportions and have used in bone tissue engineering. There have been ongoing efforts to improve the surface properties of bioglasses to increase biocompatibility and performance. The aim of the present study is to modify the bioglass surface with an amino acid mixture consisting of arginine, aspartic acid, phenylalanine, cysteine, histidine and lysine, to characterize the surface, and to evaluate the performance and biocompatibility in vitro and in vivo. The untreated bioglass, bioglass kept in simulated body fluid (SBF), and modified bioglass were used in further evaluation. After confirmation of the surface modification with FT‐IR analyses and SEM analyses, MC3T3‐E1 preosteoblasts adhesion on the surface was also revealed by SEM. The modified bioglass had significantly higher ALP activity in colorimetric measurement, rate of calcium accumulations in Alizarin red s staining, lower rate of cell death in Annexin‐V/PI staining to determine apoptosis and necrosis. Having higher cell viability rate in MTT test and absence of genotoxicity in micronucleus test (OECD 487), the modified bioglass was further confirmed for biocompatibility in vitro. The results of the rat tibial defect model revealed that the all bioglass treatments had a significantly better bone healing score compared to the untreated negative control. However, the modified bioglass exhibited significantly better bone healing efforts especially during the first and the second months compared to the other bioglass treatment treatments. As a result, the amino acid surface modification of bioglasses improves the surface biocompatibility and osteogenic performance that makes the amino acid modified bioglass a better candidate for bone tissue engineering.Research Highlights Bioglass surface modification with amino acids contributes to bioglass‐tissue interaction with an improved cell attachment. Modified bioglass increases in vitro Alp activity and calcium accumulation, and also positively affects cell behavior by supporting cell adaptation. Bioglass exerts osteogenic potential in vivo especially during early bone healing.

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Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Cited by 12 publications

References 40 publications

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Technology of Coating Deposition

Amino acid surface modified bioglass: A candidate biomaterial for bone tissue engineering¹

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Biomimetic Coating of Precalcified Ti-6Al-4V Alloy

Cited by 12 publications

References 40 publications

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Comparative Study of Sr+2 and Zn+2 Incorporation in the Biomimetic Coating of a Prosthetic Alloy

Technology of Coating Deposition

Amino acid surface modified bioglass: A candidate biomaterial for bone tissue engineering1

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Amino acid surface modified bioglass: A candidate biomaterial for bone tissue engineering¹