Biomimetic coating of bisphosphonate incorporated CDHA on Ti6Al4V

Abstract

Bi-functional coatings of carbonated calcium deficient hydroxyapatite (CDHA) on Ti alloys were developed by using a biomimetic coating process. The bi-functionality was achieved by loading alendonate sodium (AS), an approved bisphosphonate drug used for the treatment of osteoporosis, into the inner layers of CDHA coatings. Three possible methods of loading AS into CDHA coatings were systematically studied and compared. The results indicated that the co-precipitation method had greater benefits and can modify the release profile of AS by incorporating AS in the inner layers of the coatings. As a preliminary study, the influences of applied AS dosage to CDHA coatings were evaluated using XRD and SEM. In vitro tests indicated that the AS content on CDHA coatings played a significant role, and optimum AS content in local area is beneficial for osteoblast cells proliferation. It is expected that the CDHA-AS coatings via the co-precipitation approach have potential for bone tissue engineering applications.

Rapid coating of AZ31 magnesium alloy with calcium deficient hydroxyapatite using microwave energy

“…Besides the disadvantages addressed above, poor biocompatibility of the deposited coating is another shortcoming in these techniques [10]. Therefore, recent publications have focused on bioactive ceramic coatings such as calcium phosphate coatings, which presented good corrosion resistance as well as outstanding biocompatibility and bioactivity [5,8,[20][21][22].…”

“…This paper represents our attempt in coating Mg-alloys with a calcium phosphate phase with the objective to slow down the degradation rate while simultaneously making the surface more biocompatible. Over many years, our group has developed the coating technology including biomimetic coating to coat various substrates to render them more bioactive [22,[39][40][41][42][43][44][45]. Our contributions to the field include the development of special 'simulated body fluid', referred to as t-SBF.…”

“…We have developed compositions to accelerate the process [39]. Also, we developed drug containing CDHA coatings [22]. More recently we have used a microwave assisted coating process to accelerate the coating deposition kinetics [44].…”

Enhancing the Properties of Ti6Al4V as a Biomedical Material: A Review

“…In another study, bi-functional coatings of the calcium deficient carbonated hydroxyapatite (CDHA) were developed on titanium alloys by using a biomimetic coating process. An approved bisphosphonate drug, alendonate sodium (AS) which is used for the treatment of osteoporosis was loaded into the inner layers of CDHA coatings [40].…”

Deposition of PLA/CDHA composite coating via electrospraying

“…CDHA was produced using modified 1.5 Â t-SBF, with reduced content of tris-base (C 4 H 11 NO 6 ) compared to conventional 1.5 Â t-SBF reported before [13]. The compositions …”