Biomimetic cell-mediated three-dimensional assembly of halloysite nanotubes

Коннова, С. А.; Sharipova, Ilziya R.; Demina, Tatiana A.; Osin, Yu. N.; Yarullina, D. R.; Ilinskaya, О. N.; Lvov, Yuri; Fakhrullin, Rawil

doi:10.1039/c2cc38254g

Cited by 121 publications

(95 citation statements)

References 25 publications

(12 reference statements)

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“…4 Similarly, HNTs exhibit no toxicity towards Escherichia coli bacteria 32 and yeast cells. 33 Fahkrullin et al 7 reported the first example of the evaluation of halloysite toxicity in vivo on free living nematodes (worms) Caenorhabditis elegance. The authors demonstrated that HNTs were found exclusively in the intestines of the worms and no nanotubes were detected outside the intestines of the nematodes (Fig.…”

Section: Halloysite Biocompatibilitymentioning

confidence: 99%

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

et al. 2017

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a Halloysite (HNT) is a promising natural nanosized tubular clay mineral that has many important uses in different industrial fields. It is naturally occurring, biocompatible, and available in thousands of tons at low cost. As a consequence of a hollow cavity, HNT is mainly used as nanocontainer for the controlled release of several chemicals. Chemical modification of both surfaces (inner lumen and outer surface) is a strategy to tune the nanotube's properties. Specifically, chemical modification of HNT surfaces generates a nanoarchitecture with targeted affinity through outer surface functionalization and drug transport ability from functionalization of the nanotube lumen. The primary focus of this review is the research of modified halloysite nanotubes and their applications in biological and medical fields.

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Section: Halloysite Biocompatibilitymentioning

confidence: 99%

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

et al. 2017

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“…7(e) and 7(i)), suggesting that internalization may also contribute to the distribution of MNPs between proliferating cells. Growing and dividing cells are expected to gradually shed external surface coatings, as known from microbial cells [33]. Apart from highly visible aggregated MNPs localized on perinuclear areas, we expected to detect isolated nanoparticles on distal areas of cells.…”

Section: Proliferation Of Pah-mnps-coated Cellsmentioning

confidence: 99%

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

et al. 2015

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Regenerative medicine requires new ways to assemble and manipulate cells for fabrication of tissue-like constructs. Here we report a novel approach for cell surface engineering of human cells using polymer-stabilized magnetic nanoparticles (MNPs). Cationic polyelectrolyte-coated MNPs are directly deposited onto cellular membranes, producing a mesoporous semi-permeable layer and rendering cells magnetically responsive. Deposition of MNPs can be completed within minutes, under cell-friendly conditions (room temperature and physiologic media). Microscopy (TEM, SEM, AFM, and enhanced dark-field imaging) revealed the intercalation of nanoparticles into the cellular microvilli network. A detailed viability investigation was performed and suggested that MNPs do not inhibit membrane integrity, enzymatic activity, adhesion, proliferation, or cytoskeleton formation, and do not induce apoptosis in either cancer or primary cells. Finally, magnetically functionalized cells were employed to fabricate viable layered planar (two-cell layers) cell sheets and 3D multicellular spheroids.

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“…3,4 In this context, being biocompatible nanomaterials, 5,6 HNTs are mainly employed for the encapsulation of biologically active molecules, [7][8][9] biomedical implants 10,11 and controlled drug delivery. 12 Furthermore, thanks to their structural features, HNTs are suitable for a potential application as support for catalytic composites.…”

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confidence: 99%

Design of PNIPAAM covalently grafted on halloysite nanotubes as a support for metal-based catalysts

et al. 2016

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A thermo-responsive polymer such as poly(N-isopropylacrylamide) (PNIPAAM) was covalently grafted on the external surface of halloysite nanotubes (HNTs) by means of microwave irradiation. This nanomaterial was used as a support and stabilizer for palladium nanoparticles. The obtained HNT-PNIPAAM/PdNPs was characterized by means of TGA, SEM, EDS and TEM analyses. The palladium content of the catalyst was estimated to be 0.4 wt%. The stability of the catalytic material at different temperatures (below and above the PNIPAAM lower critical solution temperature) was tested in the Suzuki reaction under microwave irradiation. In addition, TEM analysis after five consecutive runs was performed. The catalyst showed a good catalytic activity toward the Suzuki cross-coupling reaction between phenylboronic acid and several aryl halides in aqueous media under microwave irradiation and low palladium loading (0.016 mol%, 8 mg of Pd). Turnover numbers (TONs) and frequencies (TOFs) up to 6250 and 37 500 h À1 , respectively, were reached. The catalyst was easily separated from the reaction mixture by centrifugation and reused for five consecutive cycles with a small drop in its catalytic activity.

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Biomimetic cell-mediated three-dimensional assembly of halloysite nanotubes

Cited by 121 publications

References 25 publications

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications

Cell surface engineering with polyelectrolyte-stabilized magnetic nanoparticles: A facile approach for fabrication of artificial multicellular tissue-mimicking clusters

Design of PNIPAAM covalently grafted on halloysite nanotubes as a support for metal-based catalysts

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