Biomimetic Catalysis

Marchetti, Louis; Levine, Mindy

doi:10.1021/cs200171u

Cited by 228 publications

(129 citation statements)

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“…In this way, NICE complements an ongoing revolution in bioinspired chemistry and materials science [2 ,3 ,4-6], which already sees applications in, for example, enzymemimics and antibody-mimics for catalysis [7][8][9][10] and in artificial photosynthesis [11 ,12 ,13-15]. These applications implement essential mechanistic steps of the biological model system at molecular and supramolecular scales.…”

Section: Q2mentioning

confidence: 99%

“…These mechanisms include: (1) use of optimized, hierarchical networks to bridge scales, minimize transport limitations, and realize efficient, scalable solutions; (2) careful balancing of forces at one or more scales to achieve superior performance, for example, in terms of yield and selectivity; (3) emergence of complex functions from simple components, using dynamics as an organizing mechanism. Figure 1 presents an overview.In this way, NICE complements an ongoing revolution in bioinspired chemistry and materials science [2 ,3 ,4-6], which already sees applications in, for example, enzymemimics and antibody-mimics for catalysis [7][8][9][10] and in artificial photosynthesis [11 ,12 ,13-15]. These applications implement essential mechanistic steps of the biological model system at molecular and supramolecular scales.…”

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confidence: 99%

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A nature-inspired approach to reactor and catalysis engineering

Coppens

2012

Current Opinion in Chemical Engineering

113

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Available online at www.sciencedirect.com A nature-inspired approach to Q1 reactor and catalysis engineering Marc-Olivier Coppens Q2Mechanisms used by biology to solve fundamental problems, such as those related to scalability, efficiency and robustness could guide the design of innovative solutions to similar challenges in chemical engineering. Complementing progress in bioinspired chemistry and materials science, we identify three methodologies as the backbone of nature-inspired reactor and catalysis engineering. First, biology often uses hierarchical networks to bridge scales and facilitate transport, leading to broadly scalable solutions that are robust, highly efficient, or both. Second, nano-confinement with carefully balanced forces at multiple scales creates structured environments with superior catalytic performance. Finally, nature employs dynamics to form synergistic and adaptable organizations from simple components. While common in nature, such mechanisms are only sporadically applied technologically in a purposeful manner. Nature-inspired chemical engineering shows great potential to innovate reactor and catalysis engineering, when using a fundamentally rooted approach, adapted to the specific context of chemical engineering processes, rather than mimicry. Introduction Nature-inspired engineering researches the fundamental mechanism underlying a desired property or function in nature, most often in biology, and applies this mechanism in a technological context. In the context of chemical engineering, we call this approach: nature-inspired chemical engineering (NICE) [1].Application of biological mechanisms to a non-physiological context in reaction engineering requires adaptations, because the relevant time scales and available building blocks are different. Also, we are able to manipulate parameters such as temperature and pressure, which are much less tunable in biology. Hence, like in an abstract portrait, essential aspects of the subject are preserved, but not literally, emphasizing those features that serve a desired purpose. Such features underpin the rational design of an artificial structure that uses the same fundamental mechanism as the natural system. The ultimate implementation is assisted by theory and experimentation. NICE aims to innovate, guided by nature, but it does not mimic nature, and should be applied in the right context.Emphasizing reactor and catalysis engineering, we illustrate how mechanisms used in biology to satisfy complicated requirements, essential to life, are adapted to guide innovative solutions to similar challenges in chemical engineering. These mechanisms include: (1) use of optimized, hierarchical networks to bridge scales, minimize transport limitations, and realize efficient, scalable solutions; (2) careful balancing of forces at one or more scales to achieve superior performance, for example, in terms of yield and selectivity; (3) emergence of complex functions from simple components, using dynamics as an organizing mechanism. Figure 1 presents an overview....

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Section: Q2mentioning

confidence: 99%

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confidence: 99%

A nature-inspired approach to reactor and catalysis engineering

Coppens

2012

Current Opinion in Chemical Engineering

113

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“…[49] In combination with host-guest chemistry, binding interactions can be spatially configured to localise organocatalytic events for enhanced catalytic proficiency. [50] Highly functionalised organocatalysts, further developed from the trifunctional prototypes, can be valuable in combining these approaches to access more complex catalysis ( Figure 5). With more organised catalytic functionalities acting in concert, the catalytic cycle may expand to incorporate a higher number of reaction components to approach the catalytic proficiency and complexity shown in biosynthetic assembly lines.…”

Section: Evolution Of Catalytic Proficiency and Complexity: Spatial Amentioning

confidence: 99%

Trifunctional Organocatalysts: Catalytic Proficiency by Cooperative Activation

Kenny

Liu

2015

Eur J Org Chem

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In this microreview, trifunctional organocatalysts, defined as catalysts with three distinct mechanistic functionalities, are surveyed in order to understand not just catalytic activation but also catalysis orchestration. Related cases in which the mechanistic trifunctionality in catalysis is conferred by more than one singular catalyst are also evaluated. The potential role of highly functionalised organocatalysts toward organized catalysis with more complexity and proficiency is subsequently discussed to anticipate new challenges in biomimetic catalysis.

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“…It has long been chemists' endeavors to draw inspiration from nature's synthetic processes to design and synthesize enzyme mimics [67], which imitate characteristic features of enzymes that facilitate efficient catalysis, including (1) high enzymesubstrate binding affinities, (2) high catalytic turnovers, (3) excellent selectivity (chemo-, regio-, diastereo-, and enantioselectivity), and (4) substantial rate accelerations as compared to uncatalyzed processes. Investigation of activation models and biosynthetic pathways in Nature offers ample opportunities for synthetic chemists to achieve similar efficient, or even more efficient, transformations.…”

Section: Borrow Ideas From Naturementioning

confidence: 99%