Biomimetic bioactive multifunctional poly(citrate-siloxane)-based nanofibrous scaffolds enable efficient multidrug-resistant bacterial treatment/non-invasive tracking in vitro/in vivo

Xi, Yang; Guo, Yi; Wang, Min; Juan, Gloria; Liu, Yanle; Niu, Wen; Chen, I‐Ming; Xue, Yumeng; Winston, Dagogo Dorothy; Dai, Wentong; Lei, Bo; Lin, Cai

doi:10.1016/j.cej.2019.123078

Cited by 23 publications

(10 citation statements)

References 39 publications

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“…Recently, the development of antimicrobial nanomaterials has attracted much attention, and the production of classic reactive oxygen species (ROS) or the penetration of the bacterial cell walls or membranes is considered the main mechanisms 9 . In contrast, extracellular polymeric substances (EPSs) adhered to the cell surfaces of biofilms would cut off nanomaterials or drugs from biofilms, reducing their antibacterial or anti-infectious efficacy 10 – 12 . The development of effective antibacterial materials that can destroy EPSs or biofilms with excellent biocompatibility and nonresistance is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions

et al. 2021

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Biofilms contribute to bacterial infection and drug resistance and are a serious threat to global human health. Antibacterial nanomaterials have attracted considerable attention, but the inhibition of biofilms remains a major challenge. Herein, we propose a nanohole-boosted electron transport (NBET) antibiofilm concept. Unlike known antibacterial mechanisms (e.g., reactive oxygen species production and cell membrane damage), nanoholes with atomic vacancies and biofilms serve as electronic donors and receptors, respectively, and thus boost the high electron transport capacity between nanomaterials and biofilms. Electron transport effectively destroys the critical components (proteins, intercellularly adhered polysaccharides and extracellular DNA) of biofilms, and the nanoholes also significantly downregulate the expression of genes related to biofilm formation. The anti-infection capacity is thoroughly verified both in vitro (human cells) and in vivo (rat ocular and mouse intestinal infection models), and the nanohole-enabled nanomaterials are found to be highly biocompatible. Importantly, compared with typical antibiotics, nanomaterials are nonresistant and thereby exhibit high potential for use in various applications. As a proof-of-principle demonstration, these findings hold promise for the use of NBET in treatments for pathogenic bacterial infection and antibiotic drug resistance.

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Section: Introductionmentioning

confidence: 99%

Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions

et al. 2021

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“…The treatment of bacterial infection after surgical tumor therapy or during the tissue repair process is very important for wound healing or disease therapy . Therefore, the antibacterial efficacy of BGN@PDA was evaluated.…”

Section: Resultsmentioning

confidence: 99%

Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration

et al. 2019

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The simultaneous therapy of tumors and bone defects resulting from tumor surgery is still a challenge in clinical orthopedics. Few nanomaterial systems simultaneously possess multifunctional capacities, including biodegradability, tumor treatment, and enhanced bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticle (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembly with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumors. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug release behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDA-DOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (HeLa cells) was significantly inhibited in vitro, and superior local anticancer efficacy could be achieved by synergic chemo-photothermal therapy in vivo. BGN@PDA underwent a gradual degradation in vivo during 60 days and showed negligible toxic side effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts in vitro and possess excellent in vivo bone repair ability in rat cranial defects. This work presents a distinctive strategy to design a bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.

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“…Compared with synthetic chemical preservatives, ɛ-PL exhibits biodegradability, water solubility and no human toxicity, and has been approved as a commercial food preservative by the U.S. Food and Drug Administration and equivalent organizations in several other countries [33,113,114]. ε-PL has been successfully used in the fields of food preservation (reviewed in detail by Tuersuntuoheti et al [13], anti-microbial treatments [115,116,117], food packaging [118], control of environmental pathogens [119], medicine (reviewed in detail by Shukla et al [120]) and agriculture (Fig. 2).…”

Section: Antimicrobial Mechanism Of ε-Pl and Its Functional Modificationmentioning

confidence: 99%

Recent advances in microbial ε-poly-L-lysine fermentation and its diverse applications

Mao

Zhang

et al. 2022

Biotechnol Biofuels

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The naturally occurring homo-polyamide biopolymer, ε-poly-L-lysine (ε-PL) consists of 25–35 L-lysine residues with amide linkages between α-carboxyl groups and ε-amino groups. ɛ-PL exhibits several useful properties because of its unusual structure, such as biodegradability, water solubility, no human toxicity, and broad-spectrum antibacterial activities; it is widely applied in the fields of food, medicine, clinical chemistry and electronics. However, current industrial production of ε-PL is only performed in a few countries. Based on an analysis of the physiological characteristics of ε-PL fermentation, current advances that enhance ε-PL fermentation, from strain improvement to product isolation are systematically reviewed, focusing on: (1) elucidating the metabolic pathway and regulatory mechanism of ε-PL synthesis; (2) enhancing biosynthetic performance through mutagenesis, fermentation optimization and metabolic engineering; and (3) understanding and improving the biological activity and functional properties of ε-PL. Finally, perspectives on engineering and exploiting ε-PL as a source material for the production of various advanced materials are also discussed, providing scientific guidelines for researchers to further improve the ε-PL fermentation process.

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Biomimetic bioactive multifunctional poly(citrate-siloxane)-based nanofibrous scaffolds enable efficient multidrug-resistant bacterial treatment/non-invasive tracking in vitro/in vivo

Cited by 23 publications

References 39 publications

Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions

Nanohole-boosted electron transport between nanomaterials and bacteria as a concept for nano–bio interactions

Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration

Recent advances in microbial ε-poly-L-lysine fermentation and its diverse applications

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