Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices

Tsiapalis, Dimitrios; Pieri, Andrea De; Biggs, Manus; Pandit, Abhay; Zeugolis, Dimitrios I.

doi:10.1021/acsbiomaterials.7b00372

Cited by 17 publications

(15 citation statements)

References 74 publications

(73 reference statements)

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“…Indeed, nHA exists in the human bone in the form of nanometer-sized threads, thus ensuring biocompatibility. At present, it is mostly used to produce surface coatings, as its biomimetic mineralization enables the production of biomaterials with biomimetic compositions and hierarchical micro/nanostructures that closely mimic the extracellular matrix of native bone tissue [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

et al. 2020

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In the present study, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) [P(3HB-co-3HHx)] was reinforced with hydroxyapatite nanoparticles (nHA) to produce novel nanocomposites for potential uses in bone reconstruction. Contents of nHA in the 2.5–20 wt % range were incorporated into P(3HB-co-3HHx) by melt compounding and the resulting pellets were shaped into parts by injection molding. The addition of nHA improved the mechanical strength and the thermomechanical resistance of the microbial copolyester parts. In particular, the addition of 20 wt % of nHA increased the tensile (Et) and flexural (Ef) moduli by approximately 64% and 61%, respectively. At the highest contents, however, the nanoparticles tended to agglomerate, and the ductility, toughness, and thermal stability of the parts also declined. The P(3HB-co-3HHx) parts filled with nHA contents of up to 10 wt % matched more closely the mechanical properties of the native bone in terms of strength and ductility when compared with metal alloys and other biopolymers used in bone tissue engineering. This fact, in combination with their biocompatibility, enables the development of nanocomposite parts to be applied as low-stress implantable devices that can promote bone reconstruction and be reabsorbed into the human body.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

et al. 2020

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“…In this frame, biomimetic and bioactive materials are emerging as promising systems able to direct and modulate cell behaviour by providing specific instructive signals, leading to the potential regeneration of healthy tissues [ 3 , 5 ]. These types of materials are often used for the design of scaffolds that aim to mimic structural, mechanical, and biological properties of natural tissues, additionally considering the complex structure at the nanoscale [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The final features of each construct depend not only on the chosen materials, but also on the used fabrication technique. Different approaches have been studied to produce nanostructured bone scaffolds, such as electrospinning [ 24 , 25 , 26 ], thermally-induced phase separation, molecular self-assembling [ 27 ], 3D printing, or combinations of them [ 5 , 12 , 13 ]. However, although all the reported technologies are able to create nanostructured constructs combining different types of both synthetic and natural biomaterials, most of them result in a lack of control over the scaffold porosity and structure.…”

Section: Introductionmentioning

confidence: 99%

“…However, although all the reported technologies are able to create nanostructured constructs combining different types of both synthetic and natural biomaterials, most of them result in a lack of control over the scaffold porosity and structure. Among nano- and micro-fabrication technologies, 3D printing is the only technique able to step over the structure limitation while offering high biomimicry and a reproducible, versatile process [ 4 , 5 , 13 , 28 , 29 , 30 ]. However, the printing of highly-complex nanostructures requires the use of biomaterials characterized by specific properties, such as shear thinning to enable material extrusion through very thin needles, as well as yield stress and fast recovery after deposition to improve the printing fidelity [ 28 , 29 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials

et al. 2018

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Bone tissue engineering offers an alternative promising solution to treat a large number of bone injuries with special focus on pathological conditions, such as osteoporosis. In this scenario, the bone tissue regeneration may be promoted using bioactive and biomimetic materials able to direct cell response, while the desired scaffold architecture can be tailored by means of 3D printing technologies. In this context, our study aimed to develop a hybrid bioactive material suitable for 3D printing of scaffolds mimicking the natural composition and structure of healthy bone. Type I collagen and strontium-containing mesoporous bioactive glasses were combined to obtain suspensions able to perform a sol-gel transition under physiological conditions. Field emission scanning electron microscopy (FESEM) analyses confirmed the formation of fibrous nanostructures homogeneously embedding inorganic particles, whereas bioactivity studies demonstrated the large calcium phosphate deposition. The high-water content promoted the strontium ion release from the embedded glass particles, potentially enhancing the osteogenic behaviour of the composite. Furthermore, the suspension printability was assessed by means of rheological studies and preliminary extrusion tests, showing shear thinning and fast material recovery upon deposition. In conclusion, the reported results suggest that promising hybrid systems suitable for 3D printing of bioactive scaffolds for bone tissue engineering have been developed.

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“… 78 Compared with traditional DDSs, biomimetic materials could imitate the intricate ECM composition and architecture, thus providing a molecular platform to enhance the control over the delivery of therapeutic molecules, bioactive cues and instructive signals. 79 , 80 Biomimetic biomaterials with biological and physicomechanical features inspired by the natural ECM were shown to be able to regulate tissue regeneration. 81 Biomimetic hydrogels, biomimetic micelles, biomimetic liposomes, biomimetic dendrimers, biomimetic polymeric carriers and biomimetic nanostructures were developed.…”

Section: Smart Drug Delivery For Bone Tissue Engineeringmentioning

confidence: 99%

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

et al. 2018

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Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals. Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material’s responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.

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Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices

Cited by 17 publications

References 74 publications

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

Assessment of the Mechanical and Thermal Properties of Injection-Molded Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/Hydroxyapatite Nanoparticles Parts for Use in Bone Tissue Engineering

Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

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