Biomimetic Approach for Ion Channels Based on Surfactant Encapsulated Spherical Porous Metal‐Oxide Capsules

Abstract

Distinguished hybrid clusters with hydrophilic and hydrophobic interiors embedded within cationic surfactant shells are spontaneously inserted into lipid bilayers, showing well-defined ionic conductance behaviors. The transport via the narrow pore gates acting as selectivity filters is controlled by the dehydration energy of the cations.

Oriented chiral water wires in artificial transmembrane channels

“…We know that the I-quartet channels are spontaneously inserted into lipid bilayers ( 12 , 14 ). Among the various methods that can be used to analyze the interactions between the I-quartets and an SLB, the QCM-D technique ( 25 – 27 ) allows detection of mass changes at the sensor surface based on the reciprocal piezoelectric effect ( 28 ). As previously observed, the formation of the SLB from small unilamellar vesicles (SUVs) follows a two-step mechanism: (i) fast adsorption of the SUVs to the QCM-D silica crystal with increased mass (that is, decreased Δ F , frequency) and increased layer flexibility (that is, increased Δ D , dissipation coefficient), because floppy SUVs were deposited on the QCM-D sensor, and (ii) rupture and fusion of SUVs into SLBs (Δ F minimum and Δ D maximum) ( Fig.…”

Thermal Responsive Ion Selectivity of Uranyl Peroxide Nanocages: An Inorganic Mimic of K+ Ion Channels

“…Inorganic molecular clusters with well‐defined porous surfaces are ideal model systems, which could refine our understanding of the transport and encapsulation behavior of ions in sub‐nanometer pores . The ion selectivity of inorganic capsules can be influenced by properties of the capsule's interior structure, the flexibility of surface pores, and exterior stimuli arising from the bulk media …”

“…[2] Given the broad applicability of ion channels,c onsiderable efforts have been dedicated to investigating ion transport and ion selectivity phenomena. [4] Thei on selectivity of inorganic capsules can be influenced by properties of the capsules interior structure, [5] the flexibility of surface pores, and exterior stimuli arising from the bulk media. [4] Thei on selectivity of inorganic capsules can be influenced by properties of the capsules interior structure, [5] the flexibility of surface pores, and exterior stimuli arising from the bulk media.…”

“…[3] Inorganic molecular clusters with well-defined porous surfaces are ideal model systems,w hich could refine our understanding of the transport and encapsulation behavior of ions in sub-nanometer pores. [4] Thei on selectivity of inorganic capsules can be influenced by properties of the capsules interior structure, [5] the flexibility of surface pores, and exterior stimuli arising from the bulk media. [6] Actinyl peroxide cage clusters,with nanopores of various sizes and rigid structure,a re promising candidates for this study.U nderstanding the properties of uranium-based nanomaterials is also fundamental for developing an advanced nuclear fuel cycle.…”

Metal–Organic Synthetic Transporters (MOST): Efficient Chloride and Antibiotic Transmembrane Transporters

“…Since functionalized platinum complexes have been shown to behave as metal–organic anion receptors in solution and many anion receptors have been incorporated into the structure of transmembrane ion transporters, it is surprising that only a few MLAs or MOFs have been studied as ion transport candidates. Large MLAs such as Cu 2+ ‐based polyhedrons, metal oxide capsules and oligo‐porphyrins with Rh 3+ , Pd 2+ , or Zn 2+ , were studied for their ionophoric properties. The large pores formed by the metal oligo‐porphyrin assemblies were shown to be very effective for the transport of large molecules such as carboxyfluorescein or tetrabutylammonium cation across phospholipid bilayers.…”