Biomimetic and Hydrophilic Vitamin B5 Analogous Methacrylamide Polymers Prevent Surface Fouling

Abstract

This study reports the synthesis of well-defined polymers of vitamin B5 analogous methacrylamide (poly­(B5AMA)) using the reversible addition fragmentation chain transfer polymerization method. The prepared telechelic poly­(B5AMA) with a predicted molecular weight and narrow polydispersities are grafted onto silanized glass surfaces using a “grafting to” approach. The polymer-treated samples are characterized for the water contact angle and surface roughness properties, as a function of polymer size and density of the polymers grafted onto the glass slides. The antifouling behavior of poly­(B5AMA)-grafted glass slides is then studied and compared with that of PEGylated glass slides, upon treatment with a variety of proteins and bacteria. The functionalized surfaces exhibit remarkable antifouling properties that are found to be dependent on both the density and the molecular weight of the grafted polymers.

Photoiniferter RAFT Polymerization of Optically Active Hydrophilic Vitamin B5 Analogous Methacrylamide

“…The kinetic studies performed above were conducted based upon our previous work on thermal polymerization of (R)-B5AMA monomer, and the choice of solvent used (10% v/v methanol in water) was mainly dictated by the solubility of monomers, TCT-1 compound, and the corresponding polymers. 26 The performance of photoiniferter polymerization using solvents of different polarities (methanol, DMSO, and dioxane) was further evaluated. Figure 3 shows the semilogarithmic kinetic curve for the polymerization of poly((R)-B5AMA) in the presence of the different solvents.…”

Chemical antifouling strategies in sensors for food analysis: A review

“…(B) Schematic of immobilizing a prepared telechelic poly‐(B5AMA) onto silanized glass surfaces using a “grafting‐to” approach (reprinted partial pictures with permission from Combita et al. [2022]). (C) Schematic of preparing e poly(HPMA‐co‐CBMAA) polymer brush on gold surface using a “grafting‐from” approach (reprinted partial pictures with permission from Riedel et al.…”

“…Combita et al. (2022) developed a vitamin B5 analogous methacrylamide (poly‐(B5AMA)) using RAFT polymerization (Figure 9B). Subsequently, poly‐(B5AMA) was grafted onto a silanized glass surface by the amidation reaction.…”

“…RAFT polymerization is a controlled/living free-radical polymerization method that does not use metal catalysts and can be applied to a wide range of monomers, including methacrylamides, acrylates, methacrylates, acrylamides, styrene derivatives, and vinylester-based monomers (Vasantha et al, 2015; Yameen F I G U R E 9 (A) Schematic of immobilizing an all-in-one dendritic peptide on the surface of biosensor by self-assembly strategy (reprinted partial pictures with permission from Liu, Ma, et al [2021]). (B) Schematic of immobilizing a prepared telechelic poly-(B5AMA) onto silanized glass surfaces using a "grafting-to" approach (reprinted partial pictures with permission from Combita et al [2022]). (C) Schematic of preparing e poly(HPMA-co-CBMAA) polymer brush on gold surface using a "grafting-from" approach (reprinted partial pictures with permission from Riedel et al [2016]).…”

“…Utrata-Wesołek et al ( 2016) attached pre-prepared polyglycidol (poly(2,3-epoxypropanol-1)) to silica wafers through a "grafting-to" approach, that is, surface-induced termination (by the reactive chloropropyl groups) of living polyether chains. Combita et al (2022) developed a vitamin B5 analogous methacrylamide (poly-(B5AMA)) using RAFT polymerization (Figure 9B). Subsequently, poly-(B5AMA) was grafted onto a silanized glass surface by the amidation reaction.…”