Biomimetic and cell-based nanocarriers – New strategies for brain tumor targeting

Mendanha, D.; Castro, Joana Vieira de; Ferreira, Helena; Neves, Nuno M.

doi:10.1016/j.jconrel.2021.07.047

Cited by 33 publications

(31 citation statements)

References 163 publications

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“…We suppose that the synthesis of NPs should be simple and efficient for intravenous administration with a high targeting ability. The use of cells or their derivatives can improve the efficiency of drug delivery, even though currently it remains at the initial stage [351]. There are several factors that prevent this strategy from reaching the clinics.…”

Section: Conclusion Discussion and Prospectsmentioning

confidence: 99%

“…Recently, cell-based delivery systems have received increased interest due to their potential for tumor applications. The main feature of such systems is their ability to mimic specific properties of organisms and deceive the system, providing site-specific delivery of therapeutic drugs [351]. In this context, the use of cells as carriers is a promising strategy for overcoming the BBB for the delivery of therapeutics to the brain tumor [352].…”

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

“…The interactions between a specific cell and brain endothelial cells can be used for developing cell membrane-coated nanocarriers that can cross the BBB and reach brain tumors. Extracellular vehicles (EVs) are an additional type of cell-based delivery system [351]. The capacity of EVs to overcome natural barriers, such as the BBB, was effectively used for delivery into brain tumors [351].…”

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

“…Extracellular vehicles (EVs) are an additional type of cell-based delivery system [351]. The capacity of EVs to overcome natural barriers, such as the BBB, was effectively used for delivery into brain tumors [351]. However, the encapsulation of hydrophilic/hydrophobic drugs into EVs can be difficult, and it can be realized by other, simpler strategies [351].…”

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

“…The capacity of EVs to overcome natural barriers, such as the BBB, was effectively used for delivery into brain tumors [351]. However, the encapsulation of hydrophilic/hydrophobic drugs into EVs can be difficult, and it can be realized by other, simpler strategies [351]. In the following sub-chapters, various cell-based delivery systems for targeting brain tumors will be presented and discussed.…”

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

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Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

et al. 2022

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Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic molecules crossing the blood–brain barrier (BBB) and reaching an appropriate targeting ability remain the key challenges. Many invasive and non-invasive methods, and various types of nanocarriers and their hybrids have been widely explored for brain tumor treatment. However, unfortunately, no crucial clinical translations were observed to date. In particular, chemotherapy and surgery remain the main methods for the therapy of brain tumors. Exploring the mechanisms of the BBB penetration in detail and investigating advanced drug delivery platforms are the key factors that could bring us closer to understanding the development of effective therapy against brain tumors. In this review, we discuss the most relevant aspects of the BBB penetration mechanisms, observing both invasive and non-invasive methods of drug delivery. We also review the recent progress in the development of functional drug delivery platforms, from viruses to cell-based vehicles, for brain tumor therapy. The destructive potential of chemotherapeutic drugs delivered to the brain tumor is also considered. This review then summarizes the existing challenges and future prospects in the use of drug delivery platforms for the treatment of brain tumors. Graphical Abstract

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Section: Conclusion Discussion and Prospectsmentioning

confidence: 99%

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

Section: Cell-based Delivery Systemsmentioning

confidence: 99%

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Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

et al. 2022

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

et al. 2022

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Biomimetic approaches utilize natural cell membrane-derived nanovesicles to camouflage nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell membrane-coating technology is inspired by naturally occurring intercellular interactions, to efficiently guide nanostructures to the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, the intrinsic biocompatibility of cell membranes allows the crossing of biological barriers and avoids elimination by the immune system. This results in enhanced blood circulation time and lower toxicity in vivo. Macrophages are the major phagocytic cells of the innate immune system. They are equipped with a complex repertoire of surface receptors, enabling them to respond to biological signals, and to exhibit a natural tropism to inflammatory sites and tumorous tissues. Macrophage cell membranefunctionalized nanosystems are designed to combine the advantages of both macrophages and nanomaterials, improving the ability of those nanosystems to reach target sites. Recent studies have demonstrated the potential of these biomimetic nanosystems for targeted delivery of drugs and imaging agents to tumors, inflammatory, and infected sites. The present review covers the preparation and biomedical applications of macrophage cell membranecoated nanosystems. Challenges and future perspectives in the development of these membrane-coated nanosystems are addressed.

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